Early differences in islets from prediabetic NOD mice: combined microarray and proteomic analysis

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• 作者：Inne Crèvecoeur ; Valborg Gudmundsdottir ; Saurabh Vig…
• 关键词：2D ; DIGE ; Beta cells ; Intrinsic differences ; Microarray ; NOD mice ; Pathway analysis ; Post ; translational modifications ; Type 1 diabetes
• 刊名：Diabetologia
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：60
• 期：3
• 页码：475-489
• 全文大小：3098KB
• 刊物类别：Medicine
• 刊物主题：Internal Medicine; Metabolic Diseases; Human Physiology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-0428
• 卷排序：60

文摘

Aims/hypothesisType 1 diabetes is an endocrine disease where a long preclinical phase, characterised by immune cell infiltration in the islets of Langerhans, precedes elevated blood glucose levels and disease onset. Although several studies have investigated the role of the immune system in this process of insulitis, the importance of the beta cells themselves in the initiation of type 1 diabetes is less well understood. The aim of this study was to investigate intrinsic differences present in the islets from diabetes-prone NOD mice before the onset of insulitis.