A lus-plus">Tbc1d1 ^{lus-plus">Ser231Ala}-knockin mutation partially impairs AICAR- but not exercise-induced muscle glucose uptake in mice

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• 作者：Qiaoli Chen ; Bingxian Xie ; Sangsang Zhu ; Ping Rong ; Yang Sheng…
• 关键词：14 ; 3 ; 3 ; AMPK ; Glucose uptake ; Phosphorylation ; TBC1D1
• 刊名：Diabetologia
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：60
• 期：2
• 页码：336-345
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Internal Medicine; Metabolic Diseases; Human Physiology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-0428
• 卷排序：60

文摘

Aims/hypothesisTBC1D1 (tre-2/USP6, BUB2, cdc16 domain family member 1) is a Rab GTPase-activating protein (RabGAP) that has been implicated in regulating GLUT4 trafficking. TBC1D1 can be phosphorylated by the AMP-activated protein kinase (AMPK) on Ser231, which consequently interacts with 14-3-3 proteins. Given the key role for AMPK in regulating insulin-independent muscle glucose uptake, we hypothesised that TBC1D1-Ser231 phosphorylation and/or 14-3-3 binding may mediate AMPK-governed glucose homeostasis.