The impact of MTHFR 677 C/T genotypes on folate status markers: a meta-analysis of folic acid intervention studies

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• 作者：Natalie J. Colson ; Helen L. Naug ; Elham Nikbakht…
• 关键词：Folate ; Folic acid ; Homocysteine ; MTHFR
• 刊名：European Journal of Nutrition
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：56
• 期：1
• 页码：247-260
• 全文大小：
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Nutrition;
• 出版者：Springer Berlin Heidelberg
• ISSN：1435-1293
• 卷排序：56

文摘

PurposeMethylenetetrahydrofolate reductase (MTHFR) is a key folate pathway enzyme with the T variant of the MTHFR gene increasing the risk of low folate status, particularly coupled with low folate intake. As genetic variability of MTHFR influences folate status, it is important to ensure an adequate intake that overrides genetic effects but minimises any adverse effects. Our aim was to assess the influence of MTHFR genotype on folate status followed by response to supplementation.