Efficacy of antifibrinolytic agents on surgical bleeding and transfusion requirements in spine surgery: a meta-analysis

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• 作者：Guang Li ; Tian-Wei Sun ; Gan Luo ; Chao Zhang
• 关键词：Antifibrinolytic agents ; Spine surgery ; Blood loss ; Blood transfusion ; Meta ; analysis
• 刊名：European Spine Journal
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：26
• 期：1
• 页码：140-154
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Surgical Orthopedics; Neurosurgery;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-0932
• 卷排序：26

文摘

PurposeSpine surgery is usually associated with large amount of blood loss and blood transfusion. Excessive blood loss may cause hypotension, inadequate oxygenation of organs, necessitate allogeneic blood transfusion, and spinal epidural hematoma formation. Aprotinin, TXA, and EACA are antifibrinolytics currently offered as prophylactic agents to reduce surgery-associated blood loss. The purpose of this study was to assess the efficacy of using antifibrinolytic agents in reducing blood loss and blood transfusions in spine surgery.