In vitro and in vivo activity of EDTA and antibacterial agents against the biofilm of mucoid Pseudomonas aeruginosa

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• 作者：Zhenqiu Liu ; Yaying Lin ; Qi Lu ; Fang Li ; Jialin Yu ; Zhengli Wang ; Yu He…
• 关键词：Pseudomonas aeruginosa ; Biofilm ; Ethylenediamine tetraacetic acid ; Antibacterial agents
• 刊名：Infection
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：45
• 期：1
• 页码：23-31
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Infectious Diseases; General Practice / Family Medicine; Internal Medicine;
• 出版者：Springer Berlin Heidelberg
• ISSN：1439-0973
• 卷排序：45

文摘

PurposeRefractory infection caused by bacterial biofilm is an important clinical problem. Pseudomonas aeruginosa is a common pathogen responsible for persistent and chronic biofilm infections. We aimed to explore the in vitro and in vivo activity of ethylenediamine tetraacetic acid (EDTA) in combination with antibacterial agents against mucoid P. aeruginosa biofilm.