The Unexpected Roles of Aurora A Kinase in Gliobastoma Recurrences

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• 作者：Estelle Willems ; Arnaud Lombard ; Matthias Dedobbeleer ; Nicolas Goffart…
• 刊名：Targeted Oncology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：12
• 期：1
• 页码：11-18
• 全文大小：
• 刊物主题：Oncology; Biomedicine, general;
• 出版者：Springer International Publishing
• ISSN：1776-260X
• 卷排序：12

文摘

The main obstacle for the cure of glioblastoma (GBM) is systematic tumor recurrence after treatment. More than 90 % of GBM tumors are indeed recurrent within 5 years after diagnosis and treatment. We urgently need new therapies to specifically address these deadly relapses. A major advance in the understanding of GBM recurrence is the identification of GBM-Initiating Cells (GIC), characterized by their abilities for self-renewal, multilineage differentiation, and proliferation. It appears that these features of GIC could be modulated by the mitotic kinase Aurora A (AurA). Indeed, besides its role in mitosis, AurA has recently been identified to regulate alternative functions like cell polarity, asymmetric cell division, and epithelial to mesenchymal transition. All these properties may help explain GBM therapeutic resistance and recurrence. 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Clin Cancer Res. 2011;17:7614–24. doi:10.1158/1078-0432.CCR-11-1536.PubMedCrossRefGoogle ScholarCopyright information© Springer International Publishing Switzerland 2016Authors and AffiliationsEstelle Willems1Arnaud Lombard12Matthias Dedobbeleer1Nicolas Goffart34Bernard Rogister15Email author1.Laboratory of Nervous System Diseases and Therapy, GIGA-NeurosciencesUniversity of LiègeLiègeBelgium2.Department of NeurosurgeryCHU and University of LiègeLiègeBelgium3.Department of Human Genetics, GIGA-CancerUniversity of LiègeLiègeBelgium4.The T&P Bohnenn Laboratory for Neuro-Oncology, Department of NeurosurgeryUMC UtrechtUtrechtThe Netherlands5.Department of NeurologyCHU and University of LiègeLiègeBelgium About this article CrossMark Publisher Name Springer International Publishing Print ISSN 1776-2596 Online ISSN 1776-260X About this journal Reprints and Permissions Co-published with