Translational MR Neuroimaging of Stroke and Recovery

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• 作者：Emiri T. Mandeville ; Cenk Ayata ; Yi Zheng…
• 关键词：Stroke ; Imaging ; MRI ; PET ; Clinical ; Experimental
• 刊名：Translational Stroke Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：8
• 期：1
• 页码：22-32
• 全文大小：
• 刊物主题：Neurosciences; Neurology; Cardiology; Neurosurgery; Vascular Surgery;
• 出版者：Springer US
• ISSN：1868-601X
• 卷排序：8

文摘

Multiparametric magnetic resonance imaging (MRI) has become a critical clinical tool for diagnosing focal ischemic stroke severity, staging treatment, and predicting outcome. Imaging during the acute phase focuses on tissue viability in the stroke vicinity, while imaging during recovery requires the evaluation of distributed structural and functional connectivity. Preclinical MRI of experimental stroke models provides validation of non-invasive biomarkers in terms of cellular and molecular mechanisms, while also providing a translational platform for evaluation of prospective therapies. This brief review of translational stroke imaging discusses the acute to chronic imaging transition, the principles underlying common MRI methods employed in stroke research, and the experimental results obtained by clinical and preclinical imaging to determine tissue viability, vascular remodeling, structural connectivity of major white matter tracts, and functional connectivity using task-based and resting-state fMRI during the stroke recovery process.