Enhanced expression of Vastatin inhibits angiogenesis and prolongs survival in murine orthotopic glioblastoma model

详细信息    查看全文

• 作者：Yi Li ; Jun Li ; Yat Ming Woo ; Zan Shen ; Hong Yao ; Yijun Cai ; Marie Chia-mi Lin…
• 关键词：Vastatin ; Glioblastoma ; Antiangiogenesis ; Gene therapy ; Chemoresistance
• 刊名：BMC Cancer
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：17
• 期：1
• 全文大小：1108KB
• 刊物主题：Cancer Research; Oncology; Surgical Oncology; Health Promotion and Disease Prevention; Biomedicine, general; Medicine/Public Health, general;
• 出版者：BioMed Central
• ISSN：1471-2407
• 卷排序：17

文摘

BackgroundAntiangiogenic therapies are considered promising for the treatment of glioblastoma (GB). The non-collagenous C-terminal globular NC1 domain of type VIII collagen a1 chain, Vastatin, is an endogenous antiangiogenic polypeptide. Sustained enhanced expression of Vastatin was shown to inhibit tumour growth and metastasis in murine hepatocellular carcinoma models. In this study, we further explored the efficacy of Vastatin in the treatment of GB xenografts.