Identification and application of anti-inflammatory compounds screening system based on RAW264.7 cells stably expressing NF-κB-dependent SEAP reporter gene

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• 作者：Yue Li ; Xiaomeng Wang ; Juan Ren ; Xi Lan ; Jing Li…
• 关键词：Reporter gene ; Inflammation ; Drug screening ; Signal pathway
• 刊名：BMC Pharmacology and Toxicology
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：18
• 期：1
• 全文大小：1747KB
• 刊物主题：Pharmacology/Toxicology;
• 出版者：BioMed Central
• ISSN：2050-6511
• 卷排序：18

文摘

BackgroundNF-κB is one of the key transcription factors in the inflammatory response, transactivates a series of pro-inflammatory genes and is therefore regarded as an important target for anti-inflammatory drug screening.