Radiopharmaceuticals for metastatic bone pain palliation: available options in the clinical domain and their comparisons

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• 作者：Tapas Das ; Sharmila Banerjee
• 关键词：Bone pain palliation ; Bone ; seeking radiopharmaceuticals ; Radiolabeled phosphonates ; Na332PO4 ; 89SrCl2 ; 117mSn ; DTPA ; 223RaCl2
• 刊名：Clinical & Experimental Metastasis
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：34
• 期：1
• 页码：1-10
• 全文大小：
• 刊物主题：Cancer Research; Biomedicine, general; Oncology; Hematology; Surgical Oncology;
• 出版者：Springer Netherlands
• ISSN：1573-7276
• 卷排序：34

文摘

Bone pain arising due to skeletal metastases is one of the common complications experienced by the majority of patients suffering from prostate, breast and lung cancer at the advanced stage of the disease. These patients are subjected to palliative care in order to improve the quality of their remaining life. With the gradually increasing number of cancer cases, palliation of metastatic bone pain is gaining importance. Bone-seeking radiopharmaceuticals play a pivotal role in the management of cancer pain, particularly in patients with multiple metastases, as these agents are proven to be effective in controlling the bone pain with minimum side effects. Although a plethora of such radiopharmaceuticals have been developed and evaluated in animal models, only a few are regularly used in clinics while some of these agents are at different stages of clinical evaluations. The present article describes only those bone-seeking radiopharmaceuticals, which have been reported to be clinically administered till date, along with their relative merits and drawbacks.