Cellular, physiological and pathological aspects of the long non-coding RNA NEAT1

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• 作者：Pang-Kuo Lo ; Benjamin Wolfson ; Qun Zhou
• 关键词：long non ; coding RNAs (lncRNAs) ; nuclear enriched abundant transcript 1 (NEAT1) ; paraspeckles ; microRNAs (miRNAs) ; epigenetic regulation ; cancer
• 刊名：Frontiers in Biology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：11
• 期：6
• 页码：413-426
• 全文大小：
• 刊物主题：Proteomics; Neurobiology; Genetics and Population Dynamics; Developmental Biology; Biochemistry, general; Cell Biology;
• 出版者：Higher Education Press
• ISSN：1674-7992
• 卷排序：11

文摘

BACKGROUNDThe majority of mammalian genomes have been found to be transcribed into non-coding RNAs. One category of non-coding RNAs is classified as long non-coding RNAs (lncRNAs) based on their transcript sizes larger than 200 nucleotides. Growing evidence has shown that lncRNAs are not junk transcripts and play regulatory roles in multiple aspects of biological processes. Dysregulation of lncRNA expression has also been linked to diseases, in particular cancer. Therefore, studies of lncRNAs have attracted significant interest in the field of medical research. Nuclear enriched abundant transcript 1 (NEAT1), a nuclear lncRNA, has recently emerged as a key regulator involved in various cellular processes, physiological responses, developmental processes, and disease development and progression.