CAPZA1 modulates EMT by regulating actin cytoskeleton remodelling in hepatocellular carcinoma

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• 作者：Deng Huang ; Li Cao ; Shuguo Zheng
• 关键词：CAPZA1 ; Actin ; Primary hepatocellular carcinoma (HCC) ; Metastasis ; Epithelial ; mesenchymal transition (EMT)
• 刊名：Journal of Experimental & Clinical Cancer Research
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：36
• 期：1
• 全文大小：4503KB
• 刊物主题：Oncology; Cancer Research; Immunology; Apoptosis;
• 出版者：BioMed Central
• ISSN：1756-9966
• 卷排序：36

文摘

BackgroundEpithelial-mesenchymal transition (EMT) elicits dramatic changes, including cytoskeleton remodelling as well as changes in gene expression and cellular phenotypes. During this process, actin filament assembly plays an important role in maintaining the morphology and movement of tumour cells. Capping protein, a protein complex referred to as CapZ, is an actin-binding complex that can regulate actin cytoskeleton remodelling. CAPZA1 is the α1 subunit of this complex, and we hypothesized that CAPZA1 regulates EMT through the regulation of actin filaments assembly, thus reducing the metastatic ability of hepatocellular carcinoma (HCC) cells.