Studies on triterpenoid glycosides from rhizomes of Panacis majoris and their antiplatelet aggregation activity

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• 作者：Min Li ; Yongri Jin ; Xiaozhong Wang ; Qian Wu&#8230
• 关键词：Panacis majoris ; Rhizome ; Triterpenoid glycoside ; Antiplatelet aggregation
• 刊名：Chemical Research in Chinese Universities
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：32
• 期：6
• 页码：943-946
• 全文大小：
• 刊物主题：Chemistry/Food Science, general; Analytical Chemistry; Inorganic Chemistry; Organic Chemistry; Physical Chemistry;
• 出版者：Jilin University and The Editorial Department of Chemical Research in Chinese Universities
• ISSN：2210-3171
• 卷排序：32

文摘

A new triterpenoid glycoside(1) and seven known triterpenoid glycosides, pseudoginsenoside RT₂(2), yesanchinoside R₂(3), vinaginsenoside R13(4), vinaginsenoside R8(5), notoginsenoside E(6), 6′′′-O-acetylginsenoside Re(7), 6″-O-acetylginsenoside Rb₁(8), were isolated from the rhizomes of Panacis majoris. The new triterpenoid glycoside was elucidated as 3-O-[β-D-glucopyranosyl-(1→2)-β-D-(6′-O-ethyl)-glucuronopyranosyl]-oleanolic acid-28-O-β-D-glucopyranoside by extensive spectroscopic and phytochemical methods. Compounds 2―rong class="EmphasisTypeBold ">8 were obtained from the plant for the first time. Compounds 3 and 4 displayed good activities against adenosine diphosphate (ADP)-induced platelet aggregation, and compounds 1, 5, 6 and 8 showed moderate activities. Compound 6 exhibited moderate antiplatelet aggregation activity induced by arachidonic acid(AA).