RAD51 G135C polymorphism is associated with breast cancer susceptibility: a meta-analysis involving 22,399 subjects

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• 作者：Haiming Sun ; Jing Bai ; Feng Chen ; Yan Jin ; Yang Yu ; Lianhong Jin and Songbin Fu
• 关键词：RAD51 ; Polymorphism ; Breast cancer ; Meta ; analysis
• 刊名：Breast Cancer Research and Treatment
• 出版年：2011
• 出版时间：January 2011
• 年：2011
• 卷：125
• 期：1
• 页码：157-161
• 全文大小：176.5 KB

文摘

Several studies have investigated the associations between RAD51 G135C polymorphism and the susceptibility to breast cancer, but results have been inconclusive. In order to derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 17 case control studies, including 12,153 cases and 10,245 controls, were selected. Overall, significant decreased risk was found for the additive model (OR = 0.995, 95 % CI = 0.991–0.998) and dominant model (OR = 0.994, 95 % CI = 0.991–0.998). In the subgroup analysis by ethnicity, statistically significantly decreased risk was found in Asians (additive model: OR = 0.977, 95 % CI = 0.954–1.000 and dominant model: OR = 0.981, 95 % CI = 0.963–1.000). In conclusion, this meta-analysis suggests that the RAD51 G135C polymorphism is a low-penetrant risk factor for developing breast cancer.