The C-type lectin-like receptors of Dectin-1 cluster in natural killer gene complex

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• 作者：Jianhui Xie (1) jxgu@shmu.edu.cn
• 关键词：C ; type lectin ; like receptors – ; Dectin ; 1 cluster – ; Natural killer gene complex – ; Myeloid cells
• 刊名：Glycoconjugate Journal
• 出版年：2012
• 出版时间：August 2012
• 年：2012
• 卷：29
• 期：5-6
• 页码：273-284
• 全文大小：262.8 KB
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• 作者单位：1. Key Laboratory of Glycoconjugate Research, Ministry of Health, Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai, 200032 China
• ISSN：1573-4986

文摘

Natural killer gene complex (NKC) encodes a group of proteins with a single C-type lectin-like domain, (CTLD) which can be subdivided several subfamilies according to their structures and expression patterns. The receptors containing the conserved calcium binding sites in the CTLD fold belong to group II of C-type lectin superfamily and are expressed on myeloid cells and non- myeloid cells. The receptors lacking conserved calcium binding sites in the CTLD fold have evolved to bind ligands other than carbohydrates independently on calcium and thereby are named as C-type lectin-like receptors. The C-type lectin-like receptors are previously thought to be exclusively expressed on natural killer (NK) cells and enable NK cells to discriminate self, missing self or altered self. However, some C-type lectin-like receptors are identified in myeloid cells and are intensely investigated, recently. These myeloid C-type lectin-like receptors, especially Dectin-1 cluster, have a wide variety of ligands, including those of exogenous origin, and play important roles in the physiological functions and pathological processes including immune homeostasis, immune defenses, and immune surveillance. In this review, we summarize each member of the Dectin-1 cluster, including their structural profiles, expression patterns, signaling properties as well as known physiological functions.