In vivo investigation of ceftiofur-loaded gelatin and PLGA microspheres in beagle dogs

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• 作者：Zhihui Hao (1)
  Leilei Wang (1)
  Kefeng Xiao (1)
  Yongda Zhao (2)
  Ming Zou (1)
  Qidi Zhang (1)
  Zhaopeng Ding (1)
  Fenfang Yang (1)
  Baohan Qu (1)
  
• 刊名：Journal of Materials Science Materials in Medicine
• 出版年：2013
• 出版时间：April 2013
• 年：2013
• 卷：24
• 期：4
• 页码：903-910
• 全文大小：354KB
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• 作者单位：Zhihui Hao (1)
  Leilei Wang (1)
  Kefeng Xiao (1)
  Yongda Zhao (2)
  Ming Zou (1)
  Qidi Zhang (1)
  Zhaopeng Ding (1)
  Fenfang Yang (1)
  Baohan Qu (1)
  
  1. Laboratories of Biological Pharmaceutical, College of Chemical and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao, 266061, China
  2. Qingdao KDN Animal Drugs Technology Development Research Center, Qingdao, 266061, China
  
• ISSN：1573-4838

文摘

Drug delivery systems based on polymer microspheres have received considerable attention. Ceftiofur sodium and ceftiofur hydrochloride is widely used for the treatment of bacterial diseases in animals but the delivery in vivo has not been reported. In this paper, we report the synthesis of microspheres from gelatin and PLGA, two kinds of typical natural and artificial materials, for loading ceftiofur and the in vivo investigation of the pharmacokinetics in beagle dogs. By controlling the synthesis parameters, gelatin and PLGA microspheres with diameter between 5 and 35?microns were obtained. Assay procedures based on high performance liquid chromatography were evaluated and confirmed. The dogs were randomly divided into three groups, i.e., control group, gelatin group, and PLGA group and administrated via intravenous injection. Plasma concentrations of ceftiofur over time were measured and analyzed. Results indicate that the main kinetic parameters do not show significant difference for the gelatin group and control group, but the area under the curve, plasma half-life, apparent volume of distribution, and clearance ratio of PLGA group show significant difference from the gelatin group and the control group. The PLGA microspheres show a low area under the curve but long time release.