Association of KIR genotype with susceptibility to HLA-B27-positive ankylosing spondylitis

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• 作者：Sheng Wang (1)
  Guixing Li (1)
  Rui Ge (1)
  Zhenhua Duan (1)
  Zhen Zeng (1)
  Tianchen Zhang (1)
  Jing Gao (1)
  Ting Yang (1)
  Si Liu (1)
  Shanshan Wu (1)
  Dazhi Fan (1)
  Shengqian Xu (2)
  Jianhua Xu (2)
  Li Zhang (3)
  Zongwen Shuai (2)
  Dongqing Ye (1)
  Yanfeng Zou (1)
  Faming Pan (1)
  
• 关键词：Ankylosing spondylitis ; HLA ; B27 ; KIR gene ; Polymorphism
• 刊名：Modern Rheumatology
• 出版年：2013
• 出版时间：May 2013
• 年：2013
• 卷：23
• 期：3
• 页码：538-541
• 全文大小：156KB
• 参考文献：1. Brophy S, Hickey S, Menon A, Taylor G, Bradbury L, Hamersma J, et al. Concordance of disease severity among family members with ankylosing spondylitis? J Rheumatol. 2004;31:1775-.
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  6. Harvey D, Pointon JJ, Sleator C, Meenagh A, Farrar C, Sun JY, et al. Analysis of killer immunoglobulin-like receptor (KIR) genes in ankylosing spondylitis. Ann Rheum Dis. 2009;68(4):595-. CrossRef
  7. Lopez-Larrea C, Blanco-Gelaz MA, Torre-Alonso JC, Bruges Armas J, Suarez-Alvarez B, Pruneda L, et al. Contribution of KIR3DL1/3DS1 to ankylosing spondylitis in human leukocyte antigen-B27 Caucasian populations. Arthritis Res Ther. 2006;8(4):R101. CrossRef
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  12. Allen RL, Raine T, Haude A, Trowsdale J, Wilson MJ. Leukocyte receptor complex-encoded immunomodulatory receptors show differing specificity for alternative HLA-B27 structures. J Immunol. 2001;167:5543-.
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• 作者单位：Sheng Wang (1)
  Guixing Li (1)
  Rui Ge (1)
  Zhenhua Duan (1)
  Zhen Zeng (1)
  Tianchen Zhang (1)
  Jing Gao (1)
  Ting Yang (1)
  Si Liu (1)
  Shanshan Wu (1)
  Dazhi Fan (1)
  Shengqian Xu (2)
  Jianhua Xu (2)
  Li Zhang (3)
  Zongwen Shuai (2)
  Dongqing Ye (1)
  Yanfeng Zou (1)
  Faming Pan (1)
  
  1. Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China
  2. Department of Rheumatism and Immunity, The First Affiliated Hospital of Anhui Medical University Hefei, Hefei, Anhui, 230032, China
  3. Anhui Medical Genetics Center, Anhui Medical College, Hefei, Anhui, 230061, China
  
• ISSN：1439-7609

文摘

Objective Recent studies have explored the role of killer cell immunoglobulin-like receptors (KIRs) in chronic autoimmune diseases. The purpose of this study was to demonstrate whether KIR genes contribute to the pathogenesis of ankylosing spondylitis (AS) in Chinese populations. Methods Sixteen KIR genes were genotyped from 60 unrelated patients with AS and 60 HLA-B27-positive matched healthy controls by PCR-SSP. The frequencies of the KIR alleles and genotypes in the AS and control groups were assessed by the χ 2 test. Results Our results showed that the frequency of the activator receptor KIR3DS1 gene in the AS group was significantly increased compared to the controls (χ 2?=?5.263, P?=?0.006, OR?=?3.059, 95?% CI?=?1.357-.896). Moreover, the frequency of the KIR3DL1/3DS1 genotype was greater in the AS group than in the control group (P?=?0.039, OR?=?3.059, 95?% CI?=?1.357-.896). In contrast, the frequency of the no KIR3DL1/no 3DS1 genotype was lower in patients with AS compared with the controls (P?=?0.032, OR?=?0.110, 95?% CI?=?0.013-.911). Conclusion KIR3DS1, in addition to HLA-B27, may play an important independent role in the pathogenesis of AS in the Chinese population.