一个镍(Ⅱ)配合物的合成、晶体结构及其与鲱鱼精DNA/BSA作用的光谱学研究

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英文篇名：Synthesis,Crystal Structure and DNA/BSA Interaction of a Ni(Ⅱ) Coordination Compound 作者：彭程佳 ; 王克华 ; 陆为学 ; 管纯倩 ; 胡雅静 ; 马双 ; 朱明昌 ; 高恩君 英文作者：PENG Chen-jia;WANG Ke-hua;LU Wei-xue;GUAN Chun-qian;HU Ya-jing;MA Shuang;ZHU Ming-chang;GAO En-jun;School of Chemistry and Life Science,Anshan Normal University;Laboratory of Coordination Chemistry,Shenyang University of Chemical Technology; 关键词：配合物 ; DNA作用 ; BSA作用 ; 晶体结构 英文关键词：Coordination complexes;;DNA binding;;BSA binding;;Crystal structure 中文刊名：GUAN 英文刊名：Spectroscopy and Spectral Analysis 机构：鞍山师范学院化学与生命科学学院;沈阳化工大学配位化学研究室; 出版日期：2019-02-15 出版单位：光谱学与光谱分析 年：2019 期：v.39 基金：国家自然科学基金项目(21671138);; 鞍山市科技计划项目(2014MS15);; 辽宁省大学生创新创业项目(201610169004)资助 语种：中文; 页：GUAN201902041 页数：6 CN：02 ISSN：11-2200/O4 分类号：233-238

摘要

合成了配合物[Ni(2,2′-biby)(H2O)4]·(Htba)2·5H2O单晶,分子式中2,2′-biby为2,2′-联吡啶,H2tba为2-硫代巴比妥酸。通过红外光谱、元素分析和单晶X-射线衍射表征其结构,单晶X-射线衍射结果表明,该配合物单晶属于正交晶系,Pbca空间群,晶胞参数为a=13.662(2),b=19.470(4),c=21.590(4)。应用紫外光谱和荧光光谱研究了其与鲱鱼精DNA/牛血清白蛋白(BSA)的相互作用,研究结果表明,标题化合物与DNA为静电结合,对牛血清白蛋白发生静态猝灭作用。
        A Ni(Ⅱ)coordination complex [Ni(2,2′-biby)(H2O)4]·(tba)2·5H2O(2,2′-biby=2,2′-dipyridine,H2tba=2-thiobarbituric acid)has been synthesized and structurally characterized by IR,element analysis and single crystal X-ray diffractometry.The results of single crystal X-ray diffractometry displayed that the title compound belongs to orthorhombic with space group of Pbca,and its cell parameters are a=13.662(2),b=19.470(4),c=21.590(4).The binding of title compound with Herring sperm DNA/BSA has been investigated by absorption and fluorescence spectra,and the results displayed that the title compound binds with DNA in electrostatic interaction mode,and quenches the intrinsic fluorescence of BSA by a static quenching mechanism.

引文

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