可见光LED的皮肤光疗应用综述
摘要
皮肤光疗是利用光线的辐射治疗皮肤类疾病或美容的治疗技术,其种类包括可见光、红外线、紫外线、激光、光化学疗法等方式。随着LED光源的发展,其在皮肤治疗领域的应用日趋广泛,其光源参数的选用对治疗效果的优劣也有着显著的影响,包括剂量、波长、照射模式等。本篇综述主要介绍了皮肤光疗的作用机制、应用领域以及光照时脉冲及连续参数的选用对治疗效果的影响。
引文
[1]张学军.皮肤性病学[M].北京:人民卫生出版社,2013.
[2]KARU T I,KOLYAKOV S F.Exact action spectra for cellular responses relevant to phototherapy[J].Photomedicine&Laser Surgery,2005,23(4):355-361.
[3]GRECO M,GUIDA G,PERLINO E,et al.Increase in RNA and protein synthesis by mitochondria irradiated with helium-neon laser[J].Biochemical&Biophysical Research Communications,1989,163(3):1428-34.
[4]KARU T I,PYATIBRAT L V,KALENDO G S.Photobiological modulation of cell attachment via cytochrome c oxidase[J].Photochemical&Photobiological Sciences,2004,3(2):211-216.
[5]MONCADA S,ERUSALIMSKY J D.OPINION:Does nitric oxide modulate mitochondrial energy generation and apoptosis[J].Nature Reviews Molecular Cell Biology,2002,3(3):214-220.
[6]杨洁,高飞.活性氧与细胞凋亡的研究进展[J].国际肿瘤学杂志,2002,29(4):30-33.
[7]LANE N.Cell biology:Power games[J].Nature,2006,443(7114):901-903.
[8]WONG-RILEY M T,LIANG H L,EELLS J T,et al.Photobiomodulation directly benefits primary neurons functionally inactivated by toxins:role of cytochrome c oxidase[J].Journal of Biological Chemistry,2005,280(6):4761-4771.
[9]SLOMINSKI A,ZBYTEK B,SZCZESNIEWSKI A,et al.CRHstimulation of corticosteroids production in melanocytes is mediated by ACTH[J].American Journal of Physiology-Endocrinology Metabolism,2005,288(4):E701-6.
[10]SLOMINSKI A,WORTSMAN J.Neuroendocrinology of the skin[J].Endocrine Reviews,2000,3(1):457-487.
[11]MIYAMURA Y,COELHO S G,WOLBER R,et al.Regulation of human skin pigmentation and responses to ultraviolet radiation[J].Pigment Cell&Melanoma Research,2007,20(1):2-13.
[12]ROUTABOUL C,DENIS A,VINCHE A.Immediate pigment darkening:description,kinetic and biological function[J].European Journal of Dermatology,1999,9(2):95-99.
[13]AVCI P,GUPTA A,SADASIVAM M,et al.Low-level laser(light)therapy(LLLT)in skin:stimulating,healing,restoring[J].Seminars in Cutaneous Medicine&Surgery,2013,32(1):41-52.
[14]HUANG Y Y,SHARMA S K,CARROLL J,et al.Biphasic dose response in low level light therapy-an update[J].DoseResponse,2011,9(4):602-618.
[15]顾恒,常宝珠,陈崑.光皮肤病学[M].北京:人民军医出版社,2009.
[16]BAROLET D.Light-emitting diodes(LEDs)in dermatology[J].Seminars in Cutaneous Medicine&Surgery,2008,27(4):227-238.
[17]赵欣研,田燕,刘玮.非相干窄谱可见光(LEDs光源)在皮肤科的应用[J].中国美容医学杂志,2015(14):82-85.
[18]田燕.LED光源在皮肤医学中的应用[J].照明工程学报,2013(s1):19-21.
[19]任捷,项蕾红.光调作用在皮肤美容中的应用[J].国际皮肤性病学杂志,2013,39(1):42-45.
[20]ABERGEL R P,LYONS R F,CASTEL J C,et al.Biostimulation of wound healing by lasers:experimental approaches in animal models and in fibroblast cultures[J].Dermatologic Surgery,1987,13(2):127-133.
[21]YU W,NAIM J O,LANZAFAME R J.The effect of laser irradiation on the release of bFGF from 3T3 fibroblasts[J].Photochemistry&Photobiology,1994,59(2):167-170.
[22]BAROLET D,ROBERGE C J,AUGER F A,et al.Regulation of skin collagen metabolism in vitro using a pulsed 660 nm LEDlight source:Clinical correlation with a single-blinded study[J].Journal of Investigative Dermatology,2009,129(12):2751-2759.
[23]BAEZ F,REILLY L R.The use of light-emitting diode therapy in the treatment of photoaged skin[J].Journal of Cosmetic Dermatology,2007,6(3):189-194.
[24]WEISS R A,MCDANIEL D H,GERONEMUS R G,et al.Clinical trial of a novel non-thermal LED array for reversal of photoaging:clinical,histologic,and surface profilometric results[J].Lasers in Surgery&Medicine,2005,36(2):85-91.
[25]LIM W,LEE S,KIM I,et al.The anti-inflammatory mechanism of 635 nm light-emitting-diode irradiation compared with existing COX inhibitors[J].Lasers in Surgery&Medicine,2007,39(7):614-621.
[26]ALSTER T S,WANITPHAKDEEDECHA R.Improvement of postfractional laser erythema with light-emitting diode photomodulation[J].Dermatologic Surgery,2009,35(5):813-815.
[27]KHOURY J G,GOLDMAN M P.Use of light-emitting diode photomodulation to reduce erythema and discomfort after intense pulsed light treatment of photodamage[J].Journal of Cosmetic Dermatology,2008,7(1):30-34.
[28]CUNLIFFE W J,GOULDEN V.Phototherapy and acne vulgaris[J].British Journal of Dermatology,2000,142(5):855-856.
[29]LEE S Y,YOU C E,MI Y P.Blue and red light combination LED phototherapy for acne vulgaris in patients with skin phototype IV[J].Lasers in Surgery&Medicine,2007,39(2):180-188.
[30]BAROLET D,BOUCHER A.Radiant near infrared light emitting Diode exposure as skin preparation to enhance photodynamic therapy inflammatory type acne treatment outcome[J].Lasers in Surgery&Medicine,2010,42(2):171-178.
[31]TRELLES M A,ALLONES I.Red light-emitting diode(LED)therapy accelerates wound healing post-blepharoplasty and periocular laser ablative resurfacing[J].Journal of Cutaneous Laser Therapy,2006,8(1):39-42.
[32]WEISS R A,MCDANIEL D H,GERONEMUS R G,et al.Clinical experience with light-emitting diode(LED)photomodulation[J].Dermatologic Surgery,2005,31(s3):1199-1205.
[33]MENEZES S,COULOMB B,LEBRETON C,et al.Noncoherent near infrared radiation protects normal human dermal fibroblasts from solar ultraviolet toxicity[J].Journal of Investigative Dermatology,1998,111(4):629-633.
[34]FRANK S,OLIVER L,LEBRETONDE C C,et al.Infrared radiation affects the mitochondrial pathway of apoptosis in human fibroblasts[J].Journal of Investigative Dermatology,2004,123(5):823-831.
[35]APPLEGATE L A,SCALETTA C,PANIZZON R,et al.Induction of the putative protective protein ferritin by infrared radiation:implications in skin repair[J].International Journal of Molecular Medicine,2000,5(3):247-251.
[36]BAROLET D,BOUCHER A.LED photoprevention:Reduced MED response following multiple LED exposures[J].Lasers in Surgery&Medicine,2008,40(2):106-112.
[37]CHEN L,XU Z,JIANG M,et al.Light-emitting diode 585nm photomodulation inhibiting melanin synthesis and inducing autophagy in human melanocytes[J].Journal of Dermatological Science,2017:S0923181117305583.
[38]马慧军.皮肤色素沉着发生机制的研究进展[J].中国美容医学,2009,18(9):1090-1092.
[39]TACHIBANA M,TAKEDA K,NOBUKUNI Y,et al.Ectopic expression of MITF,a gene for Waardenburg syndrome type 2,converts fibroblasts to cells with melanocyte characteristics[J].Nature Genetics,1996,14(1):50-54.
[40]An C.Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes[J].Journal of Proteome Research,2006,5(11):3135-3144.
[41]HU Z Z,VALENCIA J C,HUANG H,et al.Comparative bioinformatics analyses and profiling of lysosome-related organelle proteomes[J].International Journal of Mass Spectrometry,2007,259(1):147-160.
[42]OH C T,KWON T R,CHOI E J,et al.Inhibitory effect of 660-nm LED on melanin synthesis in in vitro and in vivo[J].Photodermatology Photoimmunology&Photomedicine,2016,33(1):49-57.
[43]HUANG Y Y,CHEN A C,CARROLL J D,et al.Biphasic dose response in low level light therapy[J].Dose Response,2009,7(4):358-383.
[44]MESTER E,NAGYLUCSKAY S,WAIDELICH W,et al.Effects of direct laser radiation on human lymphocytes[J].Archives of Dermatological Research,1978,263(3):241-245.
[45]ROHRINGER S,HOLNTHONER W,CHAUDARY S,et al.The impact of wavelengths of LED light-therapy on endothelial cells[J].Scientific Reports,2017,7(1):10700.
[46]BAROLET D,DUPLAY P,JACOMY H,et al.Importance of pulsing illumination parameters in lowlevel-light therapy[J].Journal of Biomedical Optics,2010,15(4):048005.
[47]STERENBORG H J,VAN GEMERT M J.Photodynamic therapy with pulsed light sources:a theoretical analysis[J].Physics in Medicine&Biology,1996,41(5):835-849.
[48]AL-WATBAN F A,ZHANG X Y.The comparison of effects between pulsed and CW lasers on wound healing[J].Journal of Clinical Laser Medicine&Surgery,2004,22(1):15-18.
[49]POGUE B W,LILGE L,PATTERSON M S,et al.Absorbed photodynamic dose from pulsed versus continuous wave light examined with tissue-simulating dosimeters[J].Applied Optics,1997,36(28):7257-69.
[50]BRONDON P,STADLER I,LANZAFAME R J.Pulsing influences photoradiation outcomes in cell culture[J].Lasers in Surgery&Medicine,2009,41(3):222-226.
[51]BAROLET D,BOUCHER A,BJERRING P.In vivo human dermal collagen production following LED-based therapy:the importance of treatment parameters[C]//54th Annual Meeting of the APS Division of Plasma Physics.American Physical Society,2005.
[52]BAROLET D,DUPLAY P,JACOMY H,et al.Importance of pulsing illumination parameters in low level-light therapy[J].Journal of Biomedical Optics,2010,15(4):048005.
[53]BAROLET D.Pulsed versus continuous wave low-level light therapy on osteoarticular signs and symptoms in limited scleroderma(CREST syndrome):a case report[J].Journal of Biomedical Optics,2014,19(11):118001.
[2]KARU T I,KOLYAKOV S F.Exact action spectra for cellular responses relevant to phototherapy[J].Photomedicine&Laser Surgery,2005,23(4):355-361.
[3]GRECO M,GUIDA G,PERLINO E,et al.Increase in RNA and protein synthesis by mitochondria irradiated with helium-neon laser[J].Biochemical&Biophysical Research Communications,1989,163(3):1428-34.
[4]KARU T I,PYATIBRAT L V,KALENDO G S.Photobiological modulation of cell attachment via cytochrome c oxidase[J].Photochemical&Photobiological Sciences,2004,3(2):211-216.
[5]MONCADA S,ERUSALIMSKY J D.OPINION:Does nitric oxide modulate mitochondrial energy generation and apoptosis[J].Nature Reviews Molecular Cell Biology,2002,3(3):214-220.
[6]杨洁,高飞.活性氧与细胞凋亡的研究进展[J].国际肿瘤学杂志,2002,29(4):30-33.
[7]LANE N.Cell biology:Power games[J].Nature,2006,443(7114):901-903.
[8]WONG-RILEY M T,LIANG H L,EELLS J T,et al.Photobiomodulation directly benefits primary neurons functionally inactivated by toxins:role of cytochrome c oxidase[J].Journal of Biological Chemistry,2005,280(6):4761-4771.
[9]SLOMINSKI A,ZBYTEK B,SZCZESNIEWSKI A,et al.CRHstimulation of corticosteroids production in melanocytes is mediated by ACTH[J].American Journal of Physiology-Endocrinology Metabolism,2005,288(4):E701-6.
[10]SLOMINSKI A,WORTSMAN J.Neuroendocrinology of the skin[J].Endocrine Reviews,2000,3(1):457-487.
[11]MIYAMURA Y,COELHO S G,WOLBER R,et al.Regulation of human skin pigmentation and responses to ultraviolet radiation[J].Pigment Cell&Melanoma Research,2007,20(1):2-13.
[12]ROUTABOUL C,DENIS A,VINCHE A.Immediate pigment darkening:description,kinetic and biological function[J].European Journal of Dermatology,1999,9(2):95-99.
[13]AVCI P,GUPTA A,SADASIVAM M,et al.Low-level laser(light)therapy(LLLT)in skin:stimulating,healing,restoring[J].Seminars in Cutaneous Medicine&Surgery,2013,32(1):41-52.
[14]HUANG Y Y,SHARMA S K,CARROLL J,et al.Biphasic dose response in low level light therapy-an update[J].DoseResponse,2011,9(4):602-618.
[15]顾恒,常宝珠,陈崑.光皮肤病学[M].北京:人民军医出版社,2009.
[16]BAROLET D.Light-emitting diodes(LEDs)in dermatology[J].Seminars in Cutaneous Medicine&Surgery,2008,27(4):227-238.
[17]赵欣研,田燕,刘玮.非相干窄谱可见光(LEDs光源)在皮肤科的应用[J].中国美容医学杂志,2015(14):82-85.
[18]田燕.LED光源在皮肤医学中的应用[J].照明工程学报,2013(s1):19-21.
[19]任捷,项蕾红.光调作用在皮肤美容中的应用[J].国际皮肤性病学杂志,2013,39(1):42-45.
[20]ABERGEL R P,LYONS R F,CASTEL J C,et al.Biostimulation of wound healing by lasers:experimental approaches in animal models and in fibroblast cultures[J].Dermatologic Surgery,1987,13(2):127-133.
[21]YU W,NAIM J O,LANZAFAME R J.The effect of laser irradiation on the release of bFGF from 3T3 fibroblasts[J].Photochemistry&Photobiology,1994,59(2):167-170.
[22]BAROLET D,ROBERGE C J,AUGER F A,et al.Regulation of skin collagen metabolism in vitro using a pulsed 660 nm LEDlight source:Clinical correlation with a single-blinded study[J].Journal of Investigative Dermatology,2009,129(12):2751-2759.
[23]BAEZ F,REILLY L R.The use of light-emitting diode therapy in the treatment of photoaged skin[J].Journal of Cosmetic Dermatology,2007,6(3):189-194.
[24]WEISS R A,MCDANIEL D H,GERONEMUS R G,et al.Clinical trial of a novel non-thermal LED array for reversal of photoaging:clinical,histologic,and surface profilometric results[J].Lasers in Surgery&Medicine,2005,36(2):85-91.
[25]LIM W,LEE S,KIM I,et al.The anti-inflammatory mechanism of 635 nm light-emitting-diode irradiation compared with existing COX inhibitors[J].Lasers in Surgery&Medicine,2007,39(7):614-621.
[26]ALSTER T S,WANITPHAKDEEDECHA R.Improvement of postfractional laser erythema with light-emitting diode photomodulation[J].Dermatologic Surgery,2009,35(5):813-815.
[27]KHOURY J G,GOLDMAN M P.Use of light-emitting diode photomodulation to reduce erythema and discomfort after intense pulsed light treatment of photodamage[J].Journal of Cosmetic Dermatology,2008,7(1):30-34.
[28]CUNLIFFE W J,GOULDEN V.Phototherapy and acne vulgaris[J].British Journal of Dermatology,2000,142(5):855-856.
[29]LEE S Y,YOU C E,MI Y P.Blue and red light combination LED phototherapy for acne vulgaris in patients with skin phototype IV[J].Lasers in Surgery&Medicine,2007,39(2):180-188.
[30]BAROLET D,BOUCHER A.Radiant near infrared light emitting Diode exposure as skin preparation to enhance photodynamic therapy inflammatory type acne treatment outcome[J].Lasers in Surgery&Medicine,2010,42(2):171-178.
[31]TRELLES M A,ALLONES I.Red light-emitting diode(LED)therapy accelerates wound healing post-blepharoplasty and periocular laser ablative resurfacing[J].Journal of Cutaneous Laser Therapy,2006,8(1):39-42.
[32]WEISS R A,MCDANIEL D H,GERONEMUS R G,et al.Clinical experience with light-emitting diode(LED)photomodulation[J].Dermatologic Surgery,2005,31(s3):1199-1205.
[33]MENEZES S,COULOMB B,LEBRETON C,et al.Noncoherent near infrared radiation protects normal human dermal fibroblasts from solar ultraviolet toxicity[J].Journal of Investigative Dermatology,1998,111(4):629-633.
[34]FRANK S,OLIVER L,LEBRETONDE C C,et al.Infrared radiation affects the mitochondrial pathway of apoptosis in human fibroblasts[J].Journal of Investigative Dermatology,2004,123(5):823-831.
[35]APPLEGATE L A,SCALETTA C,PANIZZON R,et al.Induction of the putative protective protein ferritin by infrared radiation:implications in skin repair[J].International Journal of Molecular Medicine,2000,5(3):247-251.
[36]BAROLET D,BOUCHER A.LED photoprevention:Reduced MED response following multiple LED exposures[J].Lasers in Surgery&Medicine,2008,40(2):106-112.
[37]CHEN L,XU Z,JIANG M,et al.Light-emitting diode 585nm photomodulation inhibiting melanin synthesis and inducing autophagy in human melanocytes[J].Journal of Dermatological Science,2017:S0923181117305583.
[38]马慧军.皮肤色素沉着发生机制的研究进展[J].中国美容医学,2009,18(9):1090-1092.
[39]TACHIBANA M,TAKEDA K,NOBUKUNI Y,et al.Ectopic expression of MITF,a gene for Waardenburg syndrome type 2,converts fibroblasts to cells with melanocyte characteristics[J].Nature Genetics,1996,14(1):50-54.
[40]An C.Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes[J].Journal of Proteome Research,2006,5(11):3135-3144.
[41]HU Z Z,VALENCIA J C,HUANG H,et al.Comparative bioinformatics analyses and profiling of lysosome-related organelle proteomes[J].International Journal of Mass Spectrometry,2007,259(1):147-160.
[42]OH C T,KWON T R,CHOI E J,et al.Inhibitory effect of 660-nm LED on melanin synthesis in in vitro and in vivo[J].Photodermatology Photoimmunology&Photomedicine,2016,33(1):49-57.
[43]HUANG Y Y,CHEN A C,CARROLL J D,et al.Biphasic dose response in low level light therapy[J].Dose Response,2009,7(4):358-383.
[44]MESTER E,NAGYLUCSKAY S,WAIDELICH W,et al.Effects of direct laser radiation on human lymphocytes[J].Archives of Dermatological Research,1978,263(3):241-245.
[45]ROHRINGER S,HOLNTHONER W,CHAUDARY S,et al.The impact of wavelengths of LED light-therapy on endothelial cells[J].Scientific Reports,2017,7(1):10700.
[46]BAROLET D,DUPLAY P,JACOMY H,et al.Importance of pulsing illumination parameters in lowlevel-light therapy[J].Journal of Biomedical Optics,2010,15(4):048005.
[47]STERENBORG H J,VAN GEMERT M J.Photodynamic therapy with pulsed light sources:a theoretical analysis[J].Physics in Medicine&Biology,1996,41(5):835-849.
[48]AL-WATBAN F A,ZHANG X Y.The comparison of effects between pulsed and CW lasers on wound healing[J].Journal of Clinical Laser Medicine&Surgery,2004,22(1):15-18.
[49]POGUE B W,LILGE L,PATTERSON M S,et al.Absorbed photodynamic dose from pulsed versus continuous wave light examined with tissue-simulating dosimeters[J].Applied Optics,1997,36(28):7257-69.
[50]BRONDON P,STADLER I,LANZAFAME R J.Pulsing influences photoradiation outcomes in cell culture[J].Lasers in Surgery&Medicine,2009,41(3):222-226.
[51]BAROLET D,BOUCHER A,BJERRING P.In vivo human dermal collagen production following LED-based therapy:the importance of treatment parameters[C]//54th Annual Meeting of the APS Division of Plasma Physics.American Physical Society,2005.
[52]BAROLET D,DUPLAY P,JACOMY H,et al.Importance of pulsing illumination parameters in low level-light therapy[J].Journal of Biomedical Optics,2010,15(4):048005.
[53]BAROLET D.Pulsed versus continuous wave low-level light therapy on osteoarticular signs and symptoms in limited scleroderma(CREST syndrome):a case report[J].Journal of Biomedical Optics,2014,19(11):118001.
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