脉络宁注射液联合环磷酰胺对慢性肾小球肾炎患者血液流变学、肾功能、PAI-1及t-PA的影响
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摘要
目的研究脉络宁注射液联合环磷酰胺对慢性肾小球肾炎患者血液流变学、肾功能、纤维蛋白溶解酶原激活物抑制剂-1(PAI-1)及组织型纤溶酶原激活物(t-PA)的影响。方法选择我院2015年3月-2017年3月收治的175例慢性肾小球肾炎患者,随机分为2组。对照组经环磷酰胺治疗,观察组联合脉络宁注射液治疗,比较2组的治疗效果。结果观察组有效率高于对照组(P <0.05);2组血液流变学相关指标均改善,且观察组更优(P <0.05);2组肾功能相关指标均明显降低,且观察组更低(P <0.05);2组的血清PAI-1水平均降低,t-PA水平均升高,且观察组更优(P <0.05)。结论脉络宁注射液联合环磷酰胺可有效改善慢性肾小球肾炎患者的血流速度和肾功能,并平衡其血清PAI-1及t-PA水平。
Objective To study the effect of Mailuoning Injection combined with cyclophosphamide on blood rheology, renal function, PAI-1 and t-PA in patients with chronic glomerulonephritis. Methods 175 patients with chronic glomerulonephritis admitted to our hospital from March 2015 to March 2017 were selected and randomly divided into 2 groups. The control group was treated with cyclophosphamide, and the observation group was treated with Mailuoning Injection. The therapeutic effects of the 2 groups were compared. Results The effective rate of the observation group was higher than that of the control group(P < 0.05); the blood rheology related indexes of the two groups were improved, and the observation group was better(P < 0.05). The renal function related indexes of the two groups were significantly lower, and the observation group was lower(P < 0.05). Serum PAI-1 levels were decreased in both groups, t-PA levels were elevated, and the observation group was better(P < 0.05). Conclusion Mailuoning Injection combined with cyclophosphamide can effectively improve blood flow velocity and renal function in patients with chronic glomerulonephritis, and balance its serum PAI-1 and t-PA levels.
Objective To study the effect of Mailuoning Injection combined with cyclophosphamide on blood rheology, renal function, PAI-1 and t-PA in patients with chronic glomerulonephritis. Methods 175 patients with chronic glomerulonephritis admitted to our hospital from March 2015 to March 2017 were selected and randomly divided into 2 groups. The control group was treated with cyclophosphamide, and the observation group was treated with Mailuoning Injection. The therapeutic effects of the 2 groups were compared. Results The effective rate of the observation group was higher than that of the control group(P < 0.05); the blood rheology related indexes of the two groups were improved, and the observation group was better(P < 0.05). The renal function related indexes of the two groups were significantly lower, and the observation group was lower(P < 0.05). Serum PAI-1 levels were decreased in both groups, t-PA levels were elevated, and the observation group was better(P < 0.05). Conclusion Mailuoning Injection combined with cyclophosphamide can effectively improve blood flow velocity and renal function in patients with chronic glomerulonephritis, and balance its serum PAI-1 and t-PA levels.
引文
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[17]张淑波,张玲,祝亮,等.脉络宁注射液联合贝那普利治疗慢性肾小球肾炎临床观察[J].中华中医药学刊,2017,35(11):2950-2952.
[18]程莉,苏虹梅.前列地尔联合替米沙坦对慢性肾小球肾炎患者血t-PA与PAI-1的影响及其意义[J].医学综述,2015,21(6):1110-1112.
[19]王加平,孟晓波,李恒星,等.缬沙坦联合前列地尔治疗慢性肾小球肾炎的疗效及对肾功能、血流变学、t-PA和PAI-1的影响[J].海南医学,2017,28(24):4036-4039.
[20]陈团营,朱珊,祝志朋,等.清热活血方药对过敏性紫癜肾炎患儿t-PA和PAI-1水平的影响[J].中华中医药杂志,2018,33(4):1574-1576.
[2]张莲,艾金伟,李伟男,等.肾炎康复片联合西药治疗慢性肾小球肾炎系统评价[J].中国中医药信息杂志,2016,23(12):44-50.
[3]李小莉,赵波,陈文慧,等.贝前列素钠联合羟苯磺酸钙治疗慢性肾小球肾炎疗效观察[J].疑难病杂志,2016,15(6):595-597.
[4]毛娅妮,田少江.补肾清利活血汤联合奥美沙坦酯治疗慢性肾小球肾炎疗效观察[J].现代中西医结合杂志,2017,26(10):1111-1113.
[5]王雁,周乐,李伟.益肾化湿颗粒治疗慢性肾小球肾炎脾虚湿盛证的临床疗效[J].实用医学杂志,2016,32(16):2749-2751.
[6]周静,魏昕,曾艳,等.氯沙坦钾联合益肾化湿颗粒治疗慢性肾小球肾炎的临床疗效及安全性评价[J].中国临床药理学杂志,2016,32(4):297-299.
[7]陈灏珠,林果为.实用内科学[M].13版.北京:人民卫生出版社,2009:1-3.
[8]曹美群,袁媛,孙珂焕,等.慢性肾小球肾炎唾液蛋白质组无创伤分子诊断模型的研究[J].检验医学与临床,2017,14(4):455-457.
[9]罗家佩.中医治疗慢性肾小球肾炎临床研究进展[J].中国中医药信息杂志,2016,23(6):130-133.
[10]衣芳亮.和解少阳法联合黄芪注射液对慢性肾小球肾炎蛋白尿及炎症指标的影响研究[J].现代中西医结合杂志,2016,25(15):1669-1672.
[11]郭补林,郭亚平,张家林,等.加味生地六味益肾活血汤治疗慢性肾小球肾炎疗效观察[J].陕西中医,2016,37(8):1013-1014.
[12]尹文伟,陈思,裴璐,等.脉络宁注射液辅助治疗急性脑梗死的临床观察[J].中国药房,2017,28(20):2834-2837.
[13]朱春玲,胡春芳,王代宏,等.脉络宁注射液联合贝那普利治疗慢性肾小球肾炎的临床观察[J].中国药房,2016,27(20):2801-2803.
[14]房贤村.探讨氯沙坦钾联合脉络宁注射液治疗慢性肾小球肾炎的临床治疗效果[J].世界最新医学信息文摘,2016,16(97):161.
[15]许美玲,罗颖婷.氯沙坦钾联合脉络宁注射液治疗慢性肾小球肾炎的临床疗效观察[J].临床合理用药杂志,2015,8(29):11-12.
[16]傅纪婷.中西医结合治疗慢性肾小球肾炎的临床研究[J].中国中医药现代远程教育,2016,14(15):100-101.
[17]张淑波,张玲,祝亮,等.脉络宁注射液联合贝那普利治疗慢性肾小球肾炎临床观察[J].中华中医药学刊,2017,35(11):2950-2952.
[18]程莉,苏虹梅.前列地尔联合替米沙坦对慢性肾小球肾炎患者血t-PA与PAI-1的影响及其意义[J].医学综述,2015,21(6):1110-1112.
[19]王加平,孟晓波,李恒星,等.缬沙坦联合前列地尔治疗慢性肾小球肾炎的疗效及对肾功能、血流变学、t-PA和PAI-1的影响[J].海南医学,2017,28(24):4036-4039.
[20]陈团营,朱珊,祝志朋,等.清热活血方药对过敏性紫癜肾炎患儿t-PA和PAI-1水平的影响[J].中华中医药杂志,2018,33(4):1574-1576.