面向中药产业新型分离过程的特种膜材料与装备设计、集成及应用
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摘要
人类社会的发展历程是以材料为主要标志的。《学术引领系列·国家科学思想库·未来10年中国学科发展战略:材料科学》指出:材料科学已经成为现代科学技术赖以发展与深化的实质性环节,对科学技术的发展起着基础和先导作用;一类新材料的出现还可以带动一个产业领域的诞生。过程工业对资源、能源的过度消耗和对环境的污染已经成为制约人类社会可持续发展的瓶颈问题,而化学工程一直是实现物质高效转化和能量有效利用的重要手段,进入21世纪,化学工程的目标已转化为:依托性能优越、环境友好和功能齐备的新型结构功能材料发展新的过程工业技术,形成新的工艺流程和集成技术,以达到高效、低耗、无污染的目的。膜技术以先进分离材料为载体,可在温和、低成本条件下实现物质分子水平的分离,特别适合现代工业对节能、低品位原材料再利用和消除环境污染的需要,已成为解决当代人类面临的能源、水资源、环境等领域重大问题的共性关键技术。膜材料与装备应用于中药产业可显著提升生产效率。通过分析膜材料与技术在国外医药产业和国内中医药产业的应用概况,面向中药产业应用过程的产业升级与绿色发展,提出将材料化学工程理论与方法引入中医药领域,开展具有自主知识产权的原创研究,构建以膜分离技术为核心的新型分离过程、分离流程及其专属装备,实现中药生产过程的节能减排。通过阐述20年来本课题组在中药及其复方水提液体系、油水混合体系等复杂体系分离过程产业化基础研究探索与工程化应用实践,为建立以特种膜技术为核心的中药新型分离过程的设计、集成与应用提供理论基础与应用示范。
The development of human society is mainly marked by materials. "Academic Leadership Series, National Science Think Tank, Development Strategies of Chinese Disciplines in the Next 10 Years: Material Science" points out that: Material science has become the essential link for the development and deepening of modern science and technology, and plays a basic and leading role in the development of science and technology; The emergence of a new type of material can also drive the birth of an industry. The excessive consumption of resources and energy by process industry and the pollution of environment have become bottlenecks restricting the sustainable development of human society. Chemical engineering has always been important to achieve efficient transformation of materials and effective utilization of energy. In the 21 st century, the objectives of chemical engineering have been transformed into: Relying on superior performance, friendly environment, and fully function, new structural and functional materials with good and complete functions to develop new process industrial technology and form new process flow and integration technology in order to achieve the goal of high efficiency, low consumption, and pollution-free. Membrane technology, with advanced separation materials as carriers, can achieve separation of substances and molecules at mild and low cost conditions. It is especially suitable for the needs of modern industry for energy saving, recycling of low-grade raw materials, and eliminating environmental pollution. It has become key technologies to solve the major problems in the fields of energy, water resources and environment. The application of membrane materials and equipment to the Chinese materia medica(CMM) industry can significantly improve the production efficiency. In this paper, through the analysis of the application of membrane materials and technology in foreign and domestic pharmaceutical industries, facing the industrial upgrading and green development of the application process of CMM industry, it is proposed to introduce the theory and method of material chemical engineering into the field of CMM, to carry out original research with independent intellectual property rights, and to construct a new membrane-based approach. The new separation procedure, separation process and exclusive equipment with separation technology as the core realize energy saving and emission reduction in the production process of CMM. Through expatiating on the basic research and engineering application of industrialization of separation process of CMM and its complex systems such as water extraction system and oil-water mixture system in the past 20 years, the project team provides theoretical basis and application demonstration for the design, integration, and application of new separation process of CMM based on special membrane technology.
The development of human society is mainly marked by materials. "Academic Leadership Series, National Science Think Tank, Development Strategies of Chinese Disciplines in the Next 10 Years: Material Science" points out that: Material science has become the essential link for the development and deepening of modern science and technology, and plays a basic and leading role in the development of science and technology; The emergence of a new type of material can also drive the birth of an industry. The excessive consumption of resources and energy by process industry and the pollution of environment have become bottlenecks restricting the sustainable development of human society. Chemical engineering has always been important to achieve efficient transformation of materials and effective utilization of energy. In the 21 st century, the objectives of chemical engineering have been transformed into: Relying on superior performance, friendly environment, and fully function, new structural and functional materials with good and complete functions to develop new process industrial technology and form new process flow and integration technology in order to achieve the goal of high efficiency, low consumption, and pollution-free. Membrane technology, with advanced separation materials as carriers, can achieve separation of substances and molecules at mild and low cost conditions. It is especially suitable for the needs of modern industry for energy saving, recycling of low-grade raw materials, and eliminating environmental pollution. It has become key technologies to solve the major problems in the fields of energy, water resources and environment. The application of membrane materials and equipment to the Chinese materia medica(CMM) industry can significantly improve the production efficiency. In this paper, through the analysis of the application of membrane materials and technology in foreign and domestic pharmaceutical industries, facing the industrial upgrading and green development of the application process of CMM industry, it is proposed to introduce the theory and method of material chemical engineering into the field of CMM, to carry out original research with independent intellectual property rights, and to construct a new membrane-based approach. The new separation procedure, separation process and exclusive equipment with separation technology as the core realize energy saving and emission reduction in the production process of CMM. Through expatiating on the basic research and engineering application of industrialization of separation process of CMM and its complex systems such as water extraction system and oil-water mixture system in the past 20 years, the project team provides theoretical basis and application demonstration for the design, integration, and application of new separation process of CMM based on special membrane technology.
引文
[1]国家自然科学基金委,中国科学院.《学术引领系列·国家科学思想库·未来10年中国学科发展战略:材料科学》[M].北京:科学出版社,2012.
[2]陆小华.材料化学工程中的热力学与分子模拟研究[M].北京:科学出版社,2011.
[3]郭立玮,邢卫红,朱华旭,等.中药膜技术“绿色制造”特征、国家战略需求及其关键科学问题与应对策略[J].中草药,2017,48(16):3267-3279.
[4]Dai Y,Song Y,Gao H,et al.Bibliometric analysis of research progress in membrane water treatment technology from 1985 to 2013[J].Scientometrics,2015,105(1):577-591.
[5]Zhai L,Pan Y,Guo Y,et al.International comparative study on nanofiltration membrane technology based on relevant publications and patents[J].Scientometrics,2014,101(2):1361-1374.
[6]Oatley-Radcliffe D L,Walters M,Ainscough T J,et al.Nanofiltration membranes and processes:A review of research trends over the past decade[J].J Water Process Eng,2017,19:164-171.
[7]Mannina G,Capodici M,Cosenza A,et al.UCT-MBR vs IFAS-UCT-MBR for wastewater treatment:Acomprehensive comparison including N2O emission[J].Frontiers Wastewater Treatment Modelling,2017,doi:10.1007/978-3-319-58421-8_89.
[8]Abdelrasoul A,Doan H,Lohi A,et al.Aquaporin-based biomimetic and bioinspired membranes for new frontiers in sustainable water treatment technology:Approaches and challenges[J].Polym Sci Ser A+,2018,60(4):429-450.
[9]Zhang Y,Wei S,Hu Y,et al.Membrane technology in wastewater treatment enhanced by functional nanomaterials[J].J Clean Prod,2018,197:339-348.
[10]Garcia D T,Ozer L Y,Parrino F,et al.Photocatalytic ozonation under visible light for the remediation of water effluents and its integration with an electro-membrane bioreactor[J].Chemosphere,2018,209:534-541.
[11]大矢晴彦.分离的科学与技术[M].张谨译.北京:中国轻工业出版社,1999.
[12]徐南平,高从堦,时钧.我国膜领域的重大需求与关键问题[J].中国有色金属学报,2004,14(1):327-331.
[13]徐南平.面向应用过程的陶瓷膜材料设计、制备与应用[M].北京:科学出版社,2005.
[14]龙观洪,李博,朱华旭,等.膜分离技术富集中药挥发油的可行性及其工艺过程初探--以中药青皮为例[J].膜科学与技术,2016,36(3):124-130.
[15]张梦,潘林梅,朱华旭,等.膜乳化法制备丹参酮聚乳酸-羟基乙酸微球的工艺优化[J].中国实验方剂学杂志,2014,20(5):7-11.
[16]朱华旭,唐志书,段金廒,等.面向清洁生产的中药制药过程废水资源化循环利用基本思路及其关键技术[J].中草药,2017,48(20):4133-4138.
[17]郭立玮.中药膜分离领域的科学与技术问题[J].膜科学与技术,2003,23(4):209-213.
[18]徐南平,高从堦,金万勤.中国膜科学技术的创新进展[J].中国工程科学,2014,16(12):4-9.
[19]邢卫红,陈日志,姜红,等.无机膜与膜反应器[A]//第五届中国膜科学与技术报告会论文集[C].北京:中国膜工业协会和中国膜学会,2017.
[20]朱华旭,郭立玮,李博,等.基于“中药溶液环境”学术思想的膜过程研究模式及其优化策略与方法[J].膜科学与技术,2015,35(5):127-133.
[21]李静海,胡英,袁权.探索介尺度科学:从新角度审视老问题[J].中国科学:化学,2014,44(3):277-281.
[22]董洁,朱华旭,郭立玮.黄连解毒汤模拟体系的超滤膜过程研究[J].中国中药杂志,2009,34(19):2458-2462.
[23]李博,郭立玮,吴勉华,等.基于计算机仿真技术的中药水提液中药效物质与共性高分子物质“溶液结构”及相互作用初探--以黄连解毒汤为例[J].中国实验方剂学杂志,2014,20(5):1-6.
[24]李博,张连军,郭立玮,等.基于溶液环境调节理论的黄连解毒汤陶瓷膜微滤过程的预处理研究[J].中国中药杂志,2014,39(1):59-64.
[25]李博,郭立玮,吴勉华,等.面向膜过程的小檗碱溶液“溶液结构”及与水分子相互作用的分子动力学仿真与实验研究[J].膜科学与技术,2014,34(3):37-42.
[26]张刘红,钱余义,刘静,等.超滤-反渗透集成工艺浓缩黄芩水提液的可行性[J].中国实验方剂学杂志,2014,23(20):1-5.
[27]韩志峰.微滤法用于中药挥发油含油水体的油水分离研究[D].南京:南京中医药大学,2013.
[28]龙观洪,李博,朱华旭,等.膜分离技术富集中药挥发油的可行性及其工艺过程初探--以中药青皮为例[J].膜科学与技术,2016,36(3):124-130.
[29]龙观洪.中药挥发油的蒸汽渗透膜分离过程的初步研究[D].南京:南京中医药大学,2016.
[30]张浅,朱华旭,唐志书,等.基于蒸汽渗透膜技术的中药连翘含油水体中挥发油分离工艺研究[J].中国中药杂志,2018,43(8):1642-1648.
[31]朱华旭,段金廒,郭立玮,等.基于膜科学技术的中药废弃物资源化原理及其应用实践[J].中国中药杂志,2014,39(9):34-38.
[32]段金廒.中药资源化学--理论基础与资源循环利用[M].北京:科学出版社,2015.
[33]刘双双,刘丽芳,朱华旭,等.超滤膜技术用于脉络宁注射液废弃物中多糖分离及其活性筛选研究[J].中草药,2016,47(13):2288-2293.
[34]李博,李益群,濮均文,等.基于资源化利用思路的陶瓷膜处理中药脉络宁生产废水的研究[J].膜科学与技术,2017,37(6):107-113.
[35]朱华旭,唐志书,段金廒,等.基于资源循环经济的中药脉络宁注射液废弃物资源化循环利用中的共性关键问题[J].中国现代中药,2017,19(12):1672-1676.
[2]陆小华.材料化学工程中的热力学与分子模拟研究[M].北京:科学出版社,2011.
[3]郭立玮,邢卫红,朱华旭,等.中药膜技术“绿色制造”特征、国家战略需求及其关键科学问题与应对策略[J].中草药,2017,48(16):3267-3279.
[4]Dai Y,Song Y,Gao H,et al.Bibliometric analysis of research progress in membrane water treatment technology from 1985 to 2013[J].Scientometrics,2015,105(1):577-591.
[5]Zhai L,Pan Y,Guo Y,et al.International comparative study on nanofiltration membrane technology based on relevant publications and patents[J].Scientometrics,2014,101(2):1361-1374.
[6]Oatley-Radcliffe D L,Walters M,Ainscough T J,et al.Nanofiltration membranes and processes:A review of research trends over the past decade[J].J Water Process Eng,2017,19:164-171.
[7]Mannina G,Capodici M,Cosenza A,et al.UCT-MBR vs IFAS-UCT-MBR for wastewater treatment:Acomprehensive comparison including N2O emission[J].Frontiers Wastewater Treatment Modelling,2017,doi:10.1007/978-3-319-58421-8_89.
[8]Abdelrasoul A,Doan H,Lohi A,et al.Aquaporin-based biomimetic and bioinspired membranes for new frontiers in sustainable water treatment technology:Approaches and challenges[J].Polym Sci Ser A+,2018,60(4):429-450.
[9]Zhang Y,Wei S,Hu Y,et al.Membrane technology in wastewater treatment enhanced by functional nanomaterials[J].J Clean Prod,2018,197:339-348.
[10]Garcia D T,Ozer L Y,Parrino F,et al.Photocatalytic ozonation under visible light for the remediation of water effluents and its integration with an electro-membrane bioreactor[J].Chemosphere,2018,209:534-541.
[11]大矢晴彦.分离的科学与技术[M].张谨译.北京:中国轻工业出版社,1999.
[12]徐南平,高从堦,时钧.我国膜领域的重大需求与关键问题[J].中国有色金属学报,2004,14(1):327-331.
[13]徐南平.面向应用过程的陶瓷膜材料设计、制备与应用[M].北京:科学出版社,2005.
[14]龙观洪,李博,朱华旭,等.膜分离技术富集中药挥发油的可行性及其工艺过程初探--以中药青皮为例[J].膜科学与技术,2016,36(3):124-130.
[15]张梦,潘林梅,朱华旭,等.膜乳化法制备丹参酮聚乳酸-羟基乙酸微球的工艺优化[J].中国实验方剂学杂志,2014,20(5):7-11.
[16]朱华旭,唐志书,段金廒,等.面向清洁生产的中药制药过程废水资源化循环利用基本思路及其关键技术[J].中草药,2017,48(20):4133-4138.
[17]郭立玮.中药膜分离领域的科学与技术问题[J].膜科学与技术,2003,23(4):209-213.
[18]徐南平,高从堦,金万勤.中国膜科学技术的创新进展[J].中国工程科学,2014,16(12):4-9.
[19]邢卫红,陈日志,姜红,等.无机膜与膜反应器[A]//第五届中国膜科学与技术报告会论文集[C].北京:中国膜工业协会和中国膜学会,2017.
[20]朱华旭,郭立玮,李博,等.基于“中药溶液环境”学术思想的膜过程研究模式及其优化策略与方法[J].膜科学与技术,2015,35(5):127-133.
[21]李静海,胡英,袁权.探索介尺度科学:从新角度审视老问题[J].中国科学:化学,2014,44(3):277-281.
[22]董洁,朱华旭,郭立玮.黄连解毒汤模拟体系的超滤膜过程研究[J].中国中药杂志,2009,34(19):2458-2462.
[23]李博,郭立玮,吴勉华,等.基于计算机仿真技术的中药水提液中药效物质与共性高分子物质“溶液结构”及相互作用初探--以黄连解毒汤为例[J].中国实验方剂学杂志,2014,20(5):1-6.
[24]李博,张连军,郭立玮,等.基于溶液环境调节理论的黄连解毒汤陶瓷膜微滤过程的预处理研究[J].中国中药杂志,2014,39(1):59-64.
[25]李博,郭立玮,吴勉华,等.面向膜过程的小檗碱溶液“溶液结构”及与水分子相互作用的分子动力学仿真与实验研究[J].膜科学与技术,2014,34(3):37-42.
[26]张刘红,钱余义,刘静,等.超滤-反渗透集成工艺浓缩黄芩水提液的可行性[J].中国实验方剂学杂志,2014,23(20):1-5.
[27]韩志峰.微滤法用于中药挥发油含油水体的油水分离研究[D].南京:南京中医药大学,2013.
[28]龙观洪,李博,朱华旭,等.膜分离技术富集中药挥发油的可行性及其工艺过程初探--以中药青皮为例[J].膜科学与技术,2016,36(3):124-130.
[29]龙观洪.中药挥发油的蒸汽渗透膜分离过程的初步研究[D].南京:南京中医药大学,2016.
[30]张浅,朱华旭,唐志书,等.基于蒸汽渗透膜技术的中药连翘含油水体中挥发油分离工艺研究[J].中国中药杂志,2018,43(8):1642-1648.
[31]朱华旭,段金廒,郭立玮,等.基于膜科学技术的中药废弃物资源化原理及其应用实践[J].中国中药杂志,2014,39(9):34-38.
[32]段金廒.中药资源化学--理论基础与资源循环利用[M].北京:科学出版社,2015.
[33]刘双双,刘丽芳,朱华旭,等.超滤膜技术用于脉络宁注射液废弃物中多糖分离及其活性筛选研究[J].中草药,2016,47(13):2288-2293.
[34]李博,李益群,濮均文,等.基于资源化利用思路的陶瓷膜处理中药脉络宁生产废水的研究[J].膜科学与技术,2017,37(6):107-113.
[35]朱华旭,唐志书,段金廒,等.基于资源循环经济的中药脉络宁注射液废弃物资源化循环利用中的共性关键问题[J].中国现代中药,2017,19(12):1672-1676.
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