EUGR早产儿纠正胎龄40周时生长发育迟缓发生状况及其影响因素

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英文篇名：The incidences and related influencing factors of the growth retardation of extrauterine growth restriction in preterm infants at corrected age of forty weeks 作者：孙勇 ; 桑晶 英文作者：SUN Yong;SANG Jing;Taian Central Hospital; 关键词：早产儿 ; 宫内生长发育迟缓 ; 宫外生长发育迟缓 英文关键词：preterm infant;;intrauterine growth restriction;;extrauterine growth restriction 中文刊名：TSYX 英文刊名：Journal of Taishan Medical College 机构：泰安市中心医院; 出版日期：2019-05-25 出版单位：泰山医学院学报 年：2019 期：v.40 基金：泰安市科技计划项目(2016NS1096) 语种：中文; 页：TSYX201905003 页数：3 CN：05 ISSN：37-1199/R 分类号：13-15

摘要

目的研究生长发育迟缓(extrauterine growth restriction,EUGR)早产儿纠正胎龄40周时生长发育迟缓情况及其影响因素。方法选取2014年7月至2017年12月在我院新生儿监护室(Neonatal Intensive Care Unit,NICU)住院治疗且正常出院的90例EUGR早产儿,对EUGR早产儿进行纠正胎龄40周时随访,收集相关临床资料:体重、喂养方式、疾病情况、前白蛋白、血清锌含量等,分析其纠正胎龄40周时生长发育迟缓发生情况及其影响因素。结果 EUGR早产儿在纠正胎龄40周时,生长迟缓发生率为64.4%。单因素分析显示,纠正胎龄40周时生长迟缓组与非生长迟缓组相比较,IUGR、NRDS、BPD、有创呼吸机应用、贫血、出生体重、出院体重、胎龄、住院时间、达完全肠内营养时间、前白蛋白量及喂养方式,具有统计学意义(P<0.05),Logistic回归分析显示,EUGR早产儿纠正胎龄40周时生长发育迟缓的发生与IUGR、达完全肠内营养时间、40周时前白蛋白及喂养方式有显著相关性。结论 EUGR早产儿纠正胎龄40周时生长发育迟缓问题依旧十分严峻。
        Objective:To investigate the incidences and related influencing factors of the growth retardation of extrauterine growth restriction(EUGR) in preterm infants at corrected age of forty weeks. Methods: Ninety preterm infants of EUGR who were discharged from July 2014 to December 2017 from the Neonatal Intensive Care Unit were selected for study. Regular longitudinal follow up was conducted at corrected age of forty weeks. Related clinical data, such as weight, feeding pattern, diseases, prealbumin, serum zinc were collected. The incidences and related influencing factors of the growth retardation were analyzed. Results: The incidences of the growth retardation of EUGR in preterm infants were 64.4% at corrected age of forty weeks.The single factor analysis showed that IUGR, NRDS, BPD, utilization of mechanical ventilation, anemia, birth weight, the weight at discharge, maternal age, hospitalization time, total enteral nutrition time, prealbumin and feeding patterns had significant differences between growth retardation group and non-growth retardation group at corrected age of forty weeks(P<0.05).Logistic regression analysis showed that the growth retardation of EUGR in preterm infants at corrected age of forty weeks had significant correlation with intrauterine growth restriction(IUGR), total enteral nutrition time, albumin and feeding method.Conclusion: The growth retardation at corrected age of forty weeks is extremely serious.

引文

[1] 刘丹苓,孙建华.早产儿宫外生长发育迟缓与营养支持[J].中国新生儿科杂志,2008,18(5):310-313.
    [2] 邵肖梅,叶鸿瑁,丘小汕.实用新生儿学[M].第4版.北京:人民卫生出版社,2011:46-47.
    [3] 薛辛东,杜立中,毛萌.儿科学[M].第2版.北京:人民卫生出版社,361.
    [4] 王丹华.早产儿的营养支持[J].中华围产医学杂志,2006,9(4):280-283.
    [5] Cowett RM,ed.Principles of perinatal-neonatal metabolism [M].2nd ed.New York:Springer,1998:1001-1025.
    [6] 常素芳,余崇民.预防早产儿宫外发育迟缓的营养策略[J].实用儿科学杂志,2007,22(7):544-547.
    [7] 张小宁,谭迎春,王军,等.早产儿体格生长和营养不良发生状况研究[J].中国全科医学,2013,16(36):4265-4267,4271.
    [8] 于振若,于文彬,苏明权,等.现代检验医学[M].第2版,北京:人民军医出版社,2007:448-449.
    [9] 邱小汕,黄婷婷,邓会英,等.早期营养干预对宫内生长迟缓大鼠胰岛素样生长因子和小肠发育及生长追赶的影响[J].实用儿科临床杂志,2003,18(12):949.