地特胰岛素与甘精胰岛素分别联合格列美脲治疗老年2型糖尿病的疗效观察
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摘要
目的对地特胰岛素与甘精胰岛素分别联合格列美脲治疗老年2型糖尿病的临床疗效进行探讨。方法该次研究选取该院老年病科2017年1月—2018年6月老年2型糖尿病患者68例作为研究对象,随机均分为A组和B组。A组给予地特胰岛素联合格列美脲进行治疗,B组给予甘精胰岛素联合格列美脲进行治疗,5个月后观察、比较两组患者临床疗效。结果两组患者经过治疗后,各指标均有显著改善,与治疗前比较(P<0.05)。治疗后两组在FBG、2hBG、HbAlc、FC-P、2 hcp及AuCc-p等方面比较(P>0.05)。A组患者在肥胖、超重患者比例上低于B组(P<0.05)。两组患者在低血糖发生率、血糖达标时间及胰岛素用量上比较(P>0.05)。结论地特胰岛素与甘精胰岛素在治疗老年2型糖尿病上都是不错的选择,但是地特胰岛素在控制肥胖方面略优于甘精胰岛素。
Objective To investigate the clinical efficacy of insulin detemir and insulin glargine combined with glimepiride in the treatment of type 2 diabetes mellitus in the elderly. Methods 68 elderly patients with type 2 diabetes mellitus from January 2017 to June 2018 in our hospital were enrolled in this study. They were randomly divided into group A and group B. Group A was treated with insulin detemir and glimepiride. Group B was treated with insulin glargine combined with glimepiride. After 5 months, the clinical efficacy of the two groups was observed and compared. Results After treatment, the indicators in both groups were significantly improved compared with those before treatment(P<0.05). After treatment, the two groups were compared in terms of FBG, 2 hBG, HbAlc, FC-P, 2 hcp and AuCefc-p(P>0.05). The proportion of obese and overweight patients in group A was lower than that in group B(P<0.05). The incidence of hypoglycemia, blood glucose compliance time, and insulin consumption were compared between the two groups(P>0.05). Conclusion Detemir and insulin glargine are good choices for the treatment of type 2 diabetes in the elderly, but insulin detemir is slightly better than insulin glargine in controlling obesity.
Objective To investigate the clinical efficacy of insulin detemir and insulin glargine combined with glimepiride in the treatment of type 2 diabetes mellitus in the elderly. Methods 68 elderly patients with type 2 diabetes mellitus from January 2017 to June 2018 in our hospital were enrolled in this study. They were randomly divided into group A and group B. Group A was treated with insulin detemir and glimepiride. Group B was treated with insulin glargine combined with glimepiride. After 5 months, the clinical efficacy of the two groups was observed and compared. Results After treatment, the indicators in both groups were significantly improved compared with those before treatment(P<0.05). After treatment, the two groups were compared in terms of FBG, 2 hBG, HbAlc, FC-P, 2 hcp and AuCefc-p(P>0.05). The proportion of obese and overweight patients in group A was lower than that in group B(P<0.05). The incidence of hypoglycemia, blood glucose compliance time, and insulin consumption were compared between the two groups(P>0.05). Conclusion Detemir and insulin glargine are good choices for the treatment of type 2 diabetes in the elderly, but insulin detemir is slightly better than insulin glargine in controlling obesity.
引文
[1]向敏,程新芹.地特胰岛素与甘精胰岛素联合格列美脲对2型糖尿病患者血糖及体质量的影响[J].实用临床医药杂志,2016,20(3):43-45.
[2]高国庆.甘精胰岛素与格列美脲联合应用治疗口服降糖药控制不佳的型糖尿病的有效性和安全性[J].中国保健营养,2017, 27(18):282.
[3]崔洪臣,李玉捷.甘精胰岛素对比中效胰岛素联合格列美脲治疗2型糖尿病的疗效分析[J].中国糖尿病杂志,2014,22(9):833-835.
[4]郭乃超,郑保国.地特胰岛素联合格列美脲治疗老年2型糖尿病临床疗效分析[J].现代医药卫生,2014,30(3):426-427.
[5]李薇.甘精胰岛素与地特胰岛素控制2型糖尿病的临床疗效比较[J].昆明医学院学报, 2012,33(1):115-117.
[2]高国庆.甘精胰岛素与格列美脲联合应用治疗口服降糖药控制不佳的型糖尿病的有效性和安全性[J].中国保健营养,2017, 27(18):282.
[3]崔洪臣,李玉捷.甘精胰岛素对比中效胰岛素联合格列美脲治疗2型糖尿病的疗效分析[J].中国糖尿病杂志,2014,22(9):833-835.
[4]郭乃超,郑保国.地特胰岛素联合格列美脲治疗老年2型糖尿病临床疗效分析[J].现代医药卫生,2014,30(3):426-427.
[5]李薇.甘精胰岛素与地特胰岛素控制2型糖尿病的临床疗效比较[J].昆明医学院学报, 2012,33(1):115-117.