P-gp与pCEA,CD10在肝细胞癌毛细胆管中表达的比较及其在肝细胞癌诊断中的价值

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英文篇名：Comparison of the expression of P-gp, pCEA and CD10 in the bile canaliculi of hepatocellular carcinoma 作者：孙薇 ; 赵有财 ; 田智丹 ; 杨小兵 ; 王劲松 ; 王晓蕾 ; 吕倩 ; 黄文斌 英文作者：SUN Wei;ZHAO Youcai;TIAN Zhidan;YANG Xiaobin;WANG Jingsong;WANG Xiaolei;Lü Qian;HUANG Wenbin;Department of Pathology, Jiangsu Health Vocational College;Department of Pathology, Nanjing Medical University Affiliated Nanjing Hospital/Nanjing First Hospital; 关键词：肝细胞癌 ; 毛细胆管 ; P-糖蛋白 ; pCEA ; CD10 英文关键词：hepatocellular carcinoma;;bile canaliculi;;P-glycoprotein;;pCEA;;CD10 中文刊名：WYSB 英文刊名：Journal of Clinical and Pathological Research 机构：江苏卫生健康职业学院病理学教研室;南京医科大学附属南京医院/南京市第一医院病理科; 出版日期：2019-04-28 出版单位：临床与病理杂志 年：2019 期：v.39 基金：南京市医学科技发展项目(YKK18098)~~ 语种：中文; 页：WYSB201904007 页数：5 CN：04 ISSN：43-1521/R 分类号：54-58

摘要

目的:比较P-糖蛋白(P-g l yco p ro te i n, P-g p)与p CE A, CD 1 0在肝细胞癌(h e p ato c e l l u l a r carcinoma,HCC)毛细胆管中的表达,探讨P-gp在HCC诊断中的价值。方法:应用免疫组织化学EnVision法对36例不同分化程度的HCC组织进行P-gp,pCE A,CD10标记,观察它们在毛细胆管中表达的情况。结果:P-gp,pCEA和CD10在HCC毛细胆管着色的阳性率分别为80.6%(29/36),75%(27/36)和55.6%(20/36);3个标志物中P-g p的表达较弥漫;P-g p,pCE A和CD10阳性率随着HCC分化程度的降低而降低。结论:P-gp在HCC毛细胆管中表达的阳性率与pCE A相似,两者均高于CD10,P-gp可作为HCC的辅助诊断标志物。
        Objective: To compare the expression of P-gp, pCEA and CD10 in the bile canaliculi of hepatocellular carcinoma(HCC), and to explore the value of P-gp in the diagnosis of HCC. Methods: Immunohistochemical study(EnVision method) was used to detect the expression of P-gp, pCEA and CD10 in 36 cases of HCCs with different degrees of differentiation, and the expression of them in the bile canaliculi were observed. Results:The positive rate of P-gp, pCEA and CD10 in HCC(canalicular staining pattern) were 80.6%(29/36), 75%(27/36) and 55.6%(20/36), respectively. The expression of P-gp is the most extensive in the 3 markers. It's positive rate decreased from well to poorly differentiated HCCs. Conclusion: P-gp could be a valuable marker in the assistant diagnosis of HCC. The positive rate of P-gp in the bile canaliculi of HCC was similar to that of pCEA, both were higher than that of CD10.

引文

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