利用太赫兹时域光谱法和微腔器件检测样品:综述（英文）
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摘要
简要回顾了上海理工大学在用于探测样品的太赫兹时域光谱系统和微腔器件领域的研究进展。首先,通过施加高电场研究了基于砷化镓m-i-n二极管的宽频太赫兹辐射源。然后,详细介绍了我们实验室产生的自由空间太赫兹时域光谱系统和光纤耦合太赫兹时域光谱系统及其在药物/癌症检测中的应用。为进一步提高信噪比和高灵敏度,我们引入3种通用微腔结构实现微量样品检测。本文总结了这些结构的特性、性能和潜在的传感应用。
We give a brief review of the developments in terahertz time-domain spectroscopy(THz-TDS) systems and microcavity components for probing samples in the University of Shanghai for Science and Technology. The broadband terahertz(THz) radiation sources based on GaAs m-i-n diodes have been investigated by applying high electric fields. Then, the free space THz-TDS and fiber-coupled THz-TDS systems produced in our lab and their applications in drug/cancer detection are introduced in detail. To further improve the signal-to-noise ratio(SNR) and enhance sensitivity, we introduce three general micro-cavity approaches to achieve tiny-volume sample detection, summarizing our previous results about their characteristics, performance, and potential applications.
We give a brief review of the developments in terahertz time-domain spectroscopy(THz-TDS) systems and microcavity components for probing samples in the University of Shanghai for Science and Technology. The broadband terahertz(THz) radiation sources based on GaAs m-i-n diodes have been investigated by applying high electric fields. Then, the free space THz-TDS and fiber-coupled THz-TDS systems produced in our lab and their applications in drug/cancer detection are introduced in detail. To further improve the signal-to-noise ratio(SNR) and enhance sensitivity, we introduce three general micro-cavity approaches to achieve tiny-volume sample detection, summarizing our previous results about their characteristics, performance, and potential applications.
引文
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Chen L,Xu NN,Singh L,et al.,2017.Defect-induced fano resonances in corrugated plasmonic metamaterials.Adv Opt Mater,5(8):1600960.https://doi.org/10.1002/adom.201600960
Chen WQ,Peng Y,Jiang XK,et al.,2017.Isomers identification of 2-hydroxyglutarate acid disodium salt(2HG)by terahertz time-domain spectroscopy.Sci Rep,7:12166.https://doi.org/10.1038/s41598-017-11527-z
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Fattinger C,Grischkowsky D,1988.Point source terahertz optics.Appl Phys Lett,53(16):1480-1482.https://doi.org/10.1063/1.99971
Federici J,Moeller L,2010.Review of terahertz and subterahertz wireless communications.J Appl Phys,107(11):111101.https://doi.org/10.1063/1.3386413
Ferguson B,Zhang XC,2002.Materials for terahertz science and technology.Nat Mater,1:26-33.https://doi.org/10.1038/nmat708
Ferguson B,Wang SH,Gray D,et al.,2002.T-ray computed tomography.Opt Lett,27(15):1312-1314.https://doi.org/10.1364/OL.27.001312
Ghaemi HF,Thio T,Grupp DE,et al.,1998.Surface plasmons enhance optical transmission through subwavelength holes.Phys Rev B,58(11):6779-6782.https://doi.org/10.1103/PhysRevB.58.6779
Grischkowsky G,Keiding S,van Exter M,et al.,1990.Far-infrared time-domain spectroscopy with terahertz beams of dielectrics and semiconductors.J Opt Soc Am B,7(10):2006-2015.https://doi.org/10.1364/JOSAB.7.002006
Hangyo M,Tani M,Nagashima T,2006.Terahertz timedomain spectroscopy of solids:a review.Int J Infr Millim Waves,26(12):1661-1690.https://doi.org/10.1007/s10762-005-0288-1
He JL,Liu PA,He YL,et al.,2012.Narrow bandpass tunable terahertz filter based on photonic crystal cavity.Appl Opt,51(6):776-779.https://doi.org/10.1364/AO.51.000776
Huang Y,Min CJ,Veronis G,2011.Subwavelength slow-light waveguides based on a plasmonic analogue of electromagnetically induced transparency.Appl Phys Lett,99:143117.https://doi.org/10.1063/1.3647951
Johnson C,Low FJ,Davidson AW,1980.Germanium and germanium diamond bolometers operated at 4.2 K,2.0 K,1.2 K,0.3 K,and 0.1 K.Opt Eng,19(2):192255.https://doi.org/10.1117/12.7972503
Jones RC,1947.The ultimate sensitivity of radiation detectors.J Opt Soc Am,37(11):879-890.https://doi.org/10.1364/JOSA.37.000879
Katzenellenbogen N,Grischkowsky D,1991.Efficient generation of 380 fs pulses of THz radiation by ultrafast laser pulse excitation of a biased metal-semiconductor interface.Appl Phys Lett,58(3):222-224.https://doi.org/10.1063/1.104695
Leitenstorfer A,Hunsche S,Shah J,et al.,1999.Femtosecond charge transport in polar semiconductors.Phys Rev Lett,82(25):5140-5143.https://doi.org/10.1103/PhysRevLett.82.5140
Leitenstorfer A,Hunsche S,Shah J,et al.,2000.Femtosecond high-field transport in compound semiconductors.Phys Rev B,61(24):16642-16652.https://doi.org/10.1103/PhysRevB.61.16642
Libon IH,Baumg?rtner S,Hempel M,et al.,2000.An optically controllable terahertz filter.Appl Phys Lett,76(20):2821-2823.https://doi.org/10.1063/1.126484
Liu L,Pathak R,Cheng LJ,et al.,2013.Real-time frequencydomain terahertz sensing and imaging of isopropyl alcohol-water mixtures on a microfluidic chip.Sens Actuat B,184:228-234.https://doi.org/10.1016/j.snb.2013.04.008
Lu T,Lee H,Chen T,et al.,2011.High sensitivity nanoparticle detection using optical microcavities.Proc Nat Acad Sci USA,108(15):5976-5979.https://doi.org/10.1073/pnas.1017962108
Markelz AG,2008.Terahertz dielectric sensitivity to biomolecular structure and function.IEEE J Sel Top Quant Electron,14(1):180-190.https://doi.org/10.1109/JSTQE.2007.913424
Mendis R,Astley V,Liu JB,et al.,2009.Terahertz microfluidic sensor based on a parallel-plate waveguide resonant cavity.Appl Phys Lett,95(17):171113.https://doi.org/10.1063/1.3251079
Miyamaru F,Hangyo M,2004.Finite size effect of transmission property for metal hole arrays in subterahertz region.Appl Phys Lett,84(15):2742-2744.https://doi.org/10.1063/1.1702125
Miyamaru F,Hayashi S,Otani C,et al.,2006.Terahertz surface-wave resonant sensor with a metal hole array.Opt Lett,31(8):1118-1120.https://doi.org/10.1364/OL.31.001118
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