lncRNA-SChLAP1在肝细胞癌中的表达及临床意义

详细信息    查看全文 | 推荐本文 |

英文篇名：Expression and clinical significance of lncRNA-SChLAP1 in hepatocellular carcinoma 作者：孙小艳 ; 张晓艳 英文作者：SUN Xiaoyan;ZHANG Xiaoyan;Department of Gastroenterology, Dandong First Hospital;Department of Pathology, Shenyang Fifth People′s Hospital, Shenyang Tumor Hospital; 关键词：lncRNA ; SChLAP1 ; 肝细胞癌 ; 预后 英文关键词：LncRNA;;SChLAP1;;Hepatocellular carcinoma;;Prognosis 中文刊名：GWXH 英文刊名：International Journal of Digestive Diseases 机构：丹东市第一医院消化内科;沈阳市第五人民医院沈阳市肿瘤医院病理科; 出版日期：2019-06-25 出版单位：国际消化病杂志 年：2019 期：v.39 语种：中文; 页：GWXH201903015 页数：5 CN：03 ISSN：31-1953/R 分类号：63-67

摘要

目的探究lncRNA-SChLAP1在原发性肝细胞癌(HCC)中的表达及临床意义。方法收集经手术切除的92例HCC标本及46例癌旁肝组织标本,采用RT-PCR方法检测SChLAP1的mRNA表达水平,分析其与临床病理学参数及生存期的相关性。结果 SChLAP1在HCC组织中的表达水平明显高于癌旁肝组织,差异有统计学意义(P<0.05)。SChLAP1的高表达率与肿瘤大小、临床分期、是否有门脉癌栓明显相关。门脉未侵犯组、早期组和晚期组患者行组内比较显示,SChLAP1高表达者的无病生存率和总生存率均低于低表达者。SChLAP1高表达是HCC患者预后不良的独立风险因子。结论 lncRNA-SChLAP1可作为评估HCC预后不良的潜在标志物。
        Objective This paper intended to study the expression and clinical significance of lncRNA-SChLAP1 in hepatocellular carcinoma(HCC). Methods Ninety-two specimens of hepatocellular carcinoma(HCC) and forty-six adjacent non-tumor tissue undergoing surgical operation were selected. The SChLAP1 mRNA expression was detected by using the reverse transcription-polymerase chain reaction(RT-PCR) method. Moreover, the correlation between SChLAP1 clinical pathological parameters and survival times of patients was analyzed by statistical methods. Results The expression level of SChLAP1 in HCC was obviously higher than that of adjacent non-tumor tissue(P<0.05), and obviously related to the size, venous infiltration, and clinical stage of HCC. The conjoint analysis indicates that HCC with high-expression of SChLAP1 have a significant lower disease-free survival rate and a lower overall survival rate in groups of negative venous infiltration, early-stage, and late-stage. SChLAP1 high-expression is an independent risk factor of poor prognosis for HCC patients. Conclusion lncRNA-SChLAP1 may be a potential marker for evaluation of HCC prognosis.

引文

1 de Lope CR,Tremosini S,Forner A,et al.Management of HCC[J].J Hepatol,2012,56(Suppl 1):S75-S87.
    2 Peng S,Cao L,He S,et al.An overview of long noncoding RNAs involved in bone regeneration from mesenchymal stem cells[J].Stem Cells Int,2018,2018:8273648.
    3 Mehra R,Shi Y,Udager AM,et al.A novel RNA in situ hybridization assay for the long noncoding RNA SChLAP1 predicts poor clinical outcome after radical prostatectomy in clinically localized prostate cancer[J].Neoplasia,2014,16(12):1121-1127.
    4 Prensner JR,Iyer MK,Sahu A,et al.The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex[J].Nat Genet,2013,45(11):1392-1398.
    5 Lin L,Wang Y,Tan Y,et al.High expression of lncRNA-SChLAP1 predicts poor prognosis of colorectal cancer[J].Int J Clin Exp Med,2018,11(2):904-909.
    6 Lin L,Sun J,Tan Y,et al.Prognostic implication of NQO1 overexpression in hepatocellular carcinoma[J].Hum Pathol,2017,69:31-37.
    7 Liu RT,Cao JL,Yan CQ,et al.Effects of LncRNA-HOST2 on cell proliferation,migration,invasion and apoptosis of human hepatocellular carcinoma cell line SMMC-7721[J].Biosci Rep,2017,37(2).pii:BSR20160532.
    8 Xu X,Yin Y,Tang J,et al.Long non-coding RNA Myd88 promotes growth and metastasis in hepatocellular carcinoma via regulating Myd88 expression through H3K27 modification[J].Cell Death Dis,2017,8(10):e3124.
    9 Wang X,Sun W,Shen W,et al.Long non-coding RNA DILC regulates liver cancer stem cells via IL-6/STAT3 axis[J].J Hepatol,2016,64(6):1283-1294.