昆明市妇幼保健院抗菌药物使用量与大肠埃希菌耐药率的相关性

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英文篇名：Correlation of Antibacterials Amount with Drug Resistance of Escherichia coli in Kunming Maternity and Child Health Hospital 作者：付燕 ; 李心怡 ; 袁勇 ; 王卫华 英文作者：FU Yan;LI Xin-yi;YUAN Yong;WANG Wei-hua;Dept.of Pharmaceutical Affair,Kunming Maternity and Child Health Hospital; 关键词：大肠埃希菌 ; 耐药率 ; 抗菌药物 ; 相关性 英文关键词：Escherichia coli;;Drug resistance;;Atibacterials;;Correlation 中文刊名：KMYX 英文刊名：Journal of Kunming Medical University 机构：昆明市妇幼保健院药剂科; 出版日期：2019-06-15 出版单位：昆明医科大学学报 年：2019 期：v.40 基金：昆明市卫生和计划生育委员会医药卫生科技计划项目(2017-13-01-004) 语种：中文; 页：KMYX201906025 页数：4 CN：06 ISSN：53-1221/R 分类号：127-130

摘要

目的分析抗菌药物用药频度(DDDs)与大肠埃希菌菌耐药率的相关性,为临床合理使用抗菌药物提供参考依据。方法采用回顾性调查方法,计算医院2016年1月至2018年12月大肠埃希菌每季度对12种抗菌药物的耐药率及相应的抗菌药物DDDs,并应用SPSS统计软件进行相关性分析。结果大肠埃希菌对头孢唑林、头孢西丁和头孢曲松的耐药率与头孢西丁DDDs呈正相关(r=0.658-0.803,P<0.05);头孢西丁的耐药率与头孢哌酮/舒巴坦钠的DDDs呈正相关(r=0.599,P<0.05);头孢呋辛的耐药率与头孢唑林的DDDs呈正相关(r=0.672,P<0.05)。结论某些抗菌药物的DDDs与大肠埃希菌的耐药水平之间存在相关性,应加强细菌耐药监测和抗菌药物临床应用合理性管理。
        Objective To study the correlation between antibacterials amount and drug resistance of Escherichia coli, and to provide reference for clinical use of antibacterials. Methods Retrospective review was used to calculate DDDs of antibacterials and resistance rate of Escherichia coli to 12 kinds of antibacterials each quarter.The correlation analysis was carried out using the SPSS 24.0 statistical software. Results Resistance rate of cefazolin, cefoxitin and ceftriaxone was positively correlated with DDDs of cefoxitin(r were 0.658 to 0.803,P <0.05).Resistance rate of cefoxitin was positively correlated with DDDs of cefoperazone-sulbactam(r =0.599, P <0.05) of cefuroxime was positively correlated with DDDs of cefazolin(r = 0.672, P <0.05).Conclusions There are some correlations between the DDDs and resistance rate.We should strengthen the monitoring of bacterial resistance and the management of rational application of antibacterials.

引文

[1] ARIAS C A,MURRAY B E.Antibiotic-resistant bugs in the 21st century-a clinical super-challenge[J].N Engl J Med,2009,360(5):439-443.
    [2]抗菌药物临床应用监测网.抗菌药物分类及规定日剂量(DDD):最新版[S].2011-08-01.
    [3]汪姗,徐林忠,张健,等.我院抗菌药物使用频度与3种主要革兰阴性菌耐药率的相关性分析[J].临床合理用药,2018,11(10A):102-104.
    [4]《抗菌药物临床应用指导原则》修订工作组.抗菌药物临床应用指导原则:2015年版[S].2015-07-24.
    [5] ACOG Practice Bulletin No.195:Prevention of infection after gynecologic procedures[J].Obstet Gynecol,2018,131(6):e172-e189.
    [6]张幸国,胡丽娜.临床药物治疗学各论:上册[M].北京:人民卫生出版社,2015:30.
    [7]周华,李光辉,陈佰义,等.中国产超广谱β-内酰胺酶肠杆菌科细菌应对策略专家共识[J].中华医学杂志,2014,94(24):1847-1856.
    [8]经晓杰,陈正辉,王应忠,等.急诊重症监护病房革兰阴性杆菌感染分布及耐药性[J].昆明医科大学学报,2015,36(5):69-73.
    [9]卯建,任玉吉,单斌,等.2012年至2014年中国云南地区血流感染革兰阴性杆菌的构成及耐药性[J].昆明医科大学学报,2016,37(12):24-28.
    [10]王利杰,李继泉,亢卫华,等.本院2014-2017年抗菌药物应用与细菌耐药率的相关性分析[J].中南药学,2018,16(10):1475-1479.