地塞米松对结核性脑膜炎患者脑脊液单核细胞TLR4、MyD88表达的影响

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• 论文作者：王敬 ; 周杰 ; 张书琼 ; 陈胜利 ; 张弦伟 ; 张丽娜
• 年：2016
• 作者机构：重庆三峡中心医院神经内科;重庆医科大学附属第二医院神经内科;
• 论文关键词：地塞米松 ; 结核性脑膜炎 ; 单核细胞 ; TLR4 ; My D88
• 英文论文关键词：dexamethasone ; tuberculous meningitis ; monocytes ; TLR4 ; My D88
• 会议召开时间：2016-11-25
• 会议录名称：湖南中医药大学学报2016/专集：国际数字医学会数字中医药分会成立大会暨首届数字中医药学术交流会论文集
• 语种：中文
• 分类号：R529.3
• 学会代码：HNZY
• 会议名称：国际数字医学会数字中医药分会成立大会暨首届数字中医药学术交流会
• 会议地点：中国广东珠海
• 主办单位：国际数字医学会、Digital Chinese Medicine
• 学会名称：湖南中医药大学期刊杂志社
• 页数：1
• 文件大小：1808k
• 原文格式：D
• 会议级别：全国

摘要

目的分析地塞米松治疗结核性脑膜炎患者的临床疗效及对脑脊液中单核细胞TLR4、My D88表达的影响。方法 60例结核性脑膜炎患者分为观察组和对照组,观察组36例给予常规抗结核联合地塞米松治疗,对照组仅给予抗结核治疗,分析临床疗效及两组患者脑脊液中单核细胞TLR4、My D88的表达。结果联合治疗组总有效率为91.67%,要显著好于对照组(χ2=5.17,P<0.05);地塞米松治疗能够显著降低脑脊液中单核细胞TLR4、My D88的表达水平。结论抗结核治疗联合地塞米松能显著提高治疗有效率,TLR4-My D88通路在地塞米松治疗结核性脑膜炎过程中有重要作用。
Objective To analyze the clinical efficacy of tuberculous meningitis monocyte patients treated by dexamethasone and its effect on cerebrospinal fluid mononuclear cellsTLR4, My D88 expression. Methods 60 cases of tuberculous meningitis were divided into observation group and control group, the observation group 36 cases treated with conventional anti-TBcombination with dexamethasone treatment, the control group received anti-TB treatment, clinical efficacy and the cerebrospinal fluid mononuclear cells TLR4, My D88 expression were analyzed. Results Total effective rate in combined treatment group was 91.67%, significantly better than the control group(χ2=5.17, P<0.05); dexamethasone treatment can significantly reduce TLR4, My D88 expression level. Conclusions Anti-TB combination with dexamethasone treatment can significantly improve treatment efficiency, TLR4-My D88 pathway may play an important role indexamethasone treatment tuberculous meningitis.

引文

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