接骨木概况及遗传多样性研究进展
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摘要
接骨木作为一种传统的中药材,在治疗骨折、跌打损伤、关节炎等方面有着悠久的历史,并且可以促进骨折愈合、降低血脂、改善记忆等功效。同时,接骨木是一种珍稀的木本油料作物,具有抗氧化、降血糖、降血脂的作用。故开发接骨木资源拥有一定的经济和社会效益。介绍了接骨木的概况,并对其化学成分、接骨木籽油的概况及理化指标、重金属含量、脂肪酸组成及含量、生物活性进行综述,对下一步确定其遗传距离进而进行品种指纹图谱绘制及分类研究提出了建议。
引文
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[3]Kuang H,Tang Z,Wang X,et al.Chemical constituents from Sambucus williamsii Hance fruits and hepatoprotective effects in mouse hepatocyles[J].Nat Prod Res,2017(08):1-9.
[4]曹梦晔,高昂,巩江,等.接骨木属植物药用研究概况[J].宁夏农林科技,2011,52(04):59-60.
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[9]YANG B,LIN X,TAN J,et al.Root bark of Sambucus williansii Hance promotes rat femoral fracture healing by the BMP-2/Runx2 signaling pathway [J].J Ethnopharmacol,2016,191:107-114.
[10]Zhang Y,Li Q,Wan HYet al.Study of the mechanisms by which Sambucus williamsii HANCE extract exert protecive effects against ovariecto-my-induced osteoporosis in vivo[J].Osteoporos Int,2011,22:703-709.
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[12]韩华,闫雪莹,匡海学.接骨木的研究进展[J].中医药信息,2008,25(06):14-16.
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[15]高晓旭,戚继忠.接骨木果油的超临界CO2流体萃取及其微胶囊技术研究[J].中国油脂,2005,30(11):68-70.
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[17]林晓影,杨炳友,何娅雯.接骨木根皮促进骨折愈合有效部位拆分及抗炎作用的研究[J].中医药信息,2016,33(03) :29-32.
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[22]Choi H,Lee J,Chang Y S,et al.Isolation of(一)-olivil-9’-O-o(3--D-glucopyranoside from Sambucus williamsii and its antifungal effects with membrane-disruptiveaction-[J].BBA Biomcmbranes,2013,1828(6):2002-2006.
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[24]SUH W S,SUBEDI L,KIM S Y,et al.Bioactive lignan constituents from the twigs of Sambucus williamsii[J].Bioorg Med Chem Lett,2016,26(08):1877-1880.
[25]杨序娟.接骨木抗骨质疏松活性成分的研究[D].沈阳:沈阳药科大学,2005.
[26]郭学敏,章玲,全山丛,等.接骨木化学成分的研究[J].中草药,1998,29(11):27- 729.
[27]陈可贵,胡荣,杜凤国,等.接骨木油脂分析与食用价值[J].特产研究,1993(01):58-62.
[28]SUH W S,SUBEDI L,KIM S Y,et al.Bioactive lignan constituents from the twigs of Sambucus williamsii[J].Bioorg Med Chem Lett,2016,26(08):1877-1880.
[29]倪培德.油脂加工技术[M ].北京:化学工业出版社,2007.
[30]胡荣,陈可贵,王德林.接骨木果油食用价值初探[J].吉林林学院学报,1991,07(02):76-77,64.
[31]胡荣,戚继忠,薛振平,等.药食两用木本新油源——接骨木油[J].林业科学,2005,41(01):65-70.
[32]Zakay- Rones Z,Varsano N,Zlotnik M,et al.Inhibition of several strains of influenza virus invitro and reduction of symptoms by an elderberry extract(Sambucus nigra L.)during an outbreak of influenza B panama.Altern Complement Med,1995,1(04):361.
[33]胡荣,洪海成,马德宝,等.接骨木果油降血脂作用研究[J].北华大学学报(自然科学版),2000,1(03):218-221.
[34]李炫万,沈刚哲,张善玉,等.接骨木果油抗癌作用的实验研究[J].中国中医药科技,2000,7(02):103.
[35]Zakay-Rones Z,Thom E,Wollan T,et a1.Randomized study of the efficacy and safety of oral elderberry extract in the treatment of influenza A and B virus infections.Int Med Res,2004,32:132-140.
[36]Yesilada E,Gurbuz I,Shibata H.Screening of turkish anti- ulcerogenic folk remedies for ant i- helicobacter pylori activity.J Ethnopharmacol,1999,66(03):289.
[37]刘铮,吴静生,王敏伟.接骨木油的降血脂和抗衰老作用研究[J].沈阳药科大学学报,1995,12(02):127-129.
[38]范妮娜,蒋丽华,田力,等.应用接骨木果实油(SPF)诱发小鼠体内淋巴细胞转化的实验研究[J].沈阳医学,2002,22(03):37.
[39]Mlinaric A,Kreft S,Umek A,et al.Screening of selected plant extracts for invitro inhibitory activity on HIV- 1 reverse transcriptase ( HIV- 1 RT ) .Pharmazie,2000,55 (01):75.
[40]Barak V,Halperin T,Kalickman I.The effect of sambucol,a black elderberry- based,natural product,on the production of human cytokines :I.inflammatory cytokines.Eur Cytokine Netw,2001,12(02):290.
[41]马克平.试论生物多样性的概念.生物多样性[J].生物多样性,1993,1(01):20-22.
[42]解新明,云锦风.植物遗传多样性及其检测方法[J].中国草地学报,2000(06)51-59.
[43]季维智,宿兵.遗传多样性研究的原理与方法[M].浙江:浙江科技出版社,1999.
[44]马静,安永平,王彩芬,张文银.遗传多样性研究进展[J].陕西农业科学,2010,(01)126-130.
[45]Zabeau M.,and Vos P..Selective restriction fragment aplification a general method for DNA fingerprinting European Patent Amplifiaction 92402629.7(Publiction No.0534858AI).,Paris:European Patent Office,1993.
[46]夏铭.遗传多样性研究进展[J].生态学杂志,1999,18(03):59-65.
[47]贾继增.分子标记种质资源鉴定和分子标记育种[J].中国农业科学,1996,29(04):1-10.
[48]汪维鹏,倪坤仪,周国华.单核苷酸多态性检测方法的研究进展[J].遗传,2006,28(01):117-126.
[49] 杨序娟,王乃利,黄义秀,等.接骨木中的三菇类化合物及其对类成骨细胞UMR 106的作用巨[J].沈阳药科大学学报,2005,22(06):449-452.
[50]邓俭英,刘忠,康德贤,等.RFLP分子标记及其在蔬菜研究中的应用[J].分子植物育种,2005,3(02):245-248.
[51]罗林广,王新望,罗绍春.分子标记及其在作物遗传育种中的应用[J].江西农业学报,1997,9(01):45-46.
[52]管敏强,陈锡文,赵惠玲.分子标记技术及其应用[J].实验动物科学与管理,2005,22(1):48-50.
[53]Zhang,D.-M.Phenolic Acidic Chemisriy,Chemical Industry Press,Beijing,2009:1.
[54]汪小全,邹喻苹,张大明,等.RAPD应用于遗传多样性和系统研究中的问题[J].植物学报,1996,38(12):954-962.
[55]Tautz D..Hyper variability of simple sequences as general sourcefor polymorphic DNA markers[J].Nucleic Acids Research,1989,17:6463-6471.
[56]Zhang,D.-M.Phenolic Acidic Chemisriy,Chemical Industry Press,Beijing,2009:1.
[57]Zabeau M.,and Vos P..Selective restriction fragment aplification a general method for DNA fingerprinting European Patent Amplifiaction 92402629.7(Publiction No.0534858AI).,Paris:European Patent Office,1993.
[58]田雷,曹鸣庆,王辉,等.AFLP标记技术在鉴定甘蓝种子真实性及品种纯度中的应用[J].生物技术通报,2001,14(03):38-40.
[59]王东升,周继磊,解荷峰,等.刺槐无性系遗传多样性的AFLP分析[J].西南林业学报,2012,32(06):26-29.
[60]王红霞,赵书岗,高仪,等.基于AFLP分子标志的核桃核心种质的构建[J].中国农业科学,2013,46(23):4985.
[2]杨红梅.接骨木的化学成分、药理活性和食用价值研究进展[J].人参研究,2006(04):23-25.
[3]Kuang H,Tang Z,Wang X,et al.Chemical constituents from Sambucus williamsii Hance fruits and hepatoprotective effects in mouse hepatocyles[J].Nat Prod Res,2017(08):1-9.
[4]曹梦晔,高昂,巩江,等.接骨木属植物药用研究概况[J].宁夏农林科技,2011,52(04):59-60.
[5]郑万钧.中国树木志[M].北京:中国林业出版社,1985.
[6]李春胜.接骨木的栽培与利用[J].吉林特产高等专科学校学报,2004,13(02):25-25.
[7]林敏,梅娇.复方接骨木胶囊促进股骨颈骨折愈合临床观察[J].中国中医急症,2010(08):1306-1308.
[8]Chinese Materia Medica of State Administration of Traditional Chinese Medicine Chinese Bencao [M].Shanghai:Shanghai Science and Press,2000:545-547.
[9]YANG B,LIN X,TAN J,et al.Root bark of Sambucus williansii Hance promotes rat femoral fracture healing by the BMP-2/Runx2 signaling pathway [J].J Ethnopharmacol,2016,191:107-114.
[10]Zhang Y,Li Q,Wan HYet al.Study of the mechanisms by which Sambucus williamsii HANCE extract exert protecive effects against ovariecto-my-induced osteoporosis in vivo[J].Osteoporos Int,2011,22:703-709.
[11]高云珍,刘忠颖.接骨木资源的开发与综合利用[J].林业科技情报,2014(04):114-116.
[12]韩华,闫雪莹,匡海学.接骨木的研究进展[J].中医药信息,2008,25(06):14-16.
[13]胡荣,姜炳文,胡英明,等.接骨木在日化领域中的应用[J].资源科学,1996(04):45-47.
[14]马养民,吴昊.接骨木属植物的化学成分研究进展[J].有机化学,2012,32(11):2063-2072.
[15]高晓旭,戚继忠.接骨木果油的超临界CO2流体萃取及其微胶囊技术研究[J].中国油脂,2005,30(11):68-70.
[16]胡荣,王德林,姚凯.六种野生植物油脂肪酸含量测定[J].吉林林学院学报,1992,8(02) :53-56.
[17]林晓影,杨炳友,何娅雯.接骨木根皮促进骨折愈合有效部位拆分及抗炎作用的研究[J].中医药信息,2016,33(03) :29-32.
[18]Gao,J.-M.Phytochemistry,Science Press,Beijing,2003:142-143.
[19]Lamaison,J.L.;Petitjean-Freytet,C.;Carnat,A.Ann.Pharm.Fr.1991,49,258.
[20]李安林,熊双丽.接骨木茎总黄酮的提取及DPPH自由基清除活性[J].中国食品添加剂,2015(05):113-116.
[21]欧阳富,刘远,肖辉辉,等.接骨木中木脂索类化学成分研究[J].中国中药杂志,2009,34(10):1225-1227.
[22]Choi H,Lee J,Chang Y S,et al.Isolation of(一)-olivil-9’-O-o(3--D-glucopyranoside from Sambucus williamsii and its antifungal effects with membrane-disruptiveaction-[J].BBA Biomcmbranes,2013,1828(6):2002-2006.
[23]Hwang B,Cho J,Hwang I,et al.Antifungal activity flariciresinol derived from Sambucus williamsii and their membrane-active mechanisms in Candida albicans[J].Biochem Biophys Res Commun,2011,410(3):489-493.
[24]SUH W S,SUBEDI L,KIM S Y,et al.Bioactive lignan constituents from the twigs of Sambucus williamsii[J].Bioorg Med Chem Lett,2016,26(08):1877-1880.
[25]杨序娟.接骨木抗骨质疏松活性成分的研究[D].沈阳:沈阳药科大学,2005.
[26]郭学敏,章玲,全山丛,等.接骨木化学成分的研究[J].中草药,1998,29(11):27- 729.
[27]陈可贵,胡荣,杜凤国,等.接骨木油脂分析与食用价值[J].特产研究,1993(01):58-62.
[28]SUH W S,SUBEDI L,KIM S Y,et al.Bioactive lignan constituents from the twigs of Sambucus williamsii[J].Bioorg Med Chem Lett,2016,26(08):1877-1880.
[29]倪培德.油脂加工技术[M ].北京:化学工业出版社,2007.
[30]胡荣,陈可贵,王德林.接骨木果油食用价值初探[J].吉林林学院学报,1991,07(02):76-77,64.
[31]胡荣,戚继忠,薛振平,等.药食两用木本新油源——接骨木油[J].林业科学,2005,41(01):65-70.
[32]Zakay- Rones Z,Varsano N,Zlotnik M,et al.Inhibition of several strains of influenza virus invitro and reduction of symptoms by an elderberry extract(Sambucus nigra L.)during an outbreak of influenza B panama.Altern Complement Med,1995,1(04):361.
[33]胡荣,洪海成,马德宝,等.接骨木果油降血脂作用研究[J].北华大学学报(自然科学版),2000,1(03):218-221.
[34]李炫万,沈刚哲,张善玉,等.接骨木果油抗癌作用的实验研究[J].中国中医药科技,2000,7(02):103.
[35]Zakay-Rones Z,Thom E,Wollan T,et a1.Randomized study of the efficacy and safety of oral elderberry extract in the treatment of influenza A and B virus infections.Int Med Res,2004,32:132-140.
[36]Yesilada E,Gurbuz I,Shibata H.Screening of turkish anti- ulcerogenic folk remedies for ant i- helicobacter pylori activity.J Ethnopharmacol,1999,66(03):289.
[37]刘铮,吴静生,王敏伟.接骨木油的降血脂和抗衰老作用研究[J].沈阳药科大学学报,1995,12(02):127-129.
[38]范妮娜,蒋丽华,田力,等.应用接骨木果实油(SPF)诱发小鼠体内淋巴细胞转化的实验研究[J].沈阳医学,2002,22(03):37.
[39]Mlinaric A,Kreft S,Umek A,et al.Screening of selected plant extracts for invitro inhibitory activity on HIV- 1 reverse transcriptase ( HIV- 1 RT ) .Pharmazie,2000,55 (01):75.
[40]Barak V,Halperin T,Kalickman I.The effect of sambucol,a black elderberry- based,natural product,on the production of human cytokines :I.inflammatory cytokines.Eur Cytokine Netw,2001,12(02):290.
[41]马克平.试论生物多样性的概念.生物多样性[J].生物多样性,1993,1(01):20-22.
[42]解新明,云锦风.植物遗传多样性及其检测方法[J].中国草地学报,2000(06)51-59.
[43]季维智,宿兵.遗传多样性研究的原理与方法[M].浙江:浙江科技出版社,1999.
[44]马静,安永平,王彩芬,张文银.遗传多样性研究进展[J].陕西农业科学,2010,(01)126-130.
[45]Zabeau M.,and Vos P..Selective restriction fragment aplification a general method for DNA fingerprinting European Patent Amplifiaction 92402629.7(Publiction No.0534858AI).,Paris:European Patent Office,1993.
[46]夏铭.遗传多样性研究进展[J].生态学杂志,1999,18(03):59-65.
[47]贾继增.分子标记种质资源鉴定和分子标记育种[J].中国农业科学,1996,29(04):1-10.
[48]汪维鹏,倪坤仪,周国华.单核苷酸多态性检测方法的研究进展[J].遗传,2006,28(01):117-126.
[49] 杨序娟,王乃利,黄义秀,等.接骨木中的三菇类化合物及其对类成骨细胞UMR 106的作用巨[J].沈阳药科大学学报,2005,22(06):449-452.
[50]邓俭英,刘忠,康德贤,等.RFLP分子标记及其在蔬菜研究中的应用[J].分子植物育种,2005,3(02):245-248.
[51]罗林广,王新望,罗绍春.分子标记及其在作物遗传育种中的应用[J].江西农业学报,1997,9(01):45-46.
[52]管敏强,陈锡文,赵惠玲.分子标记技术及其应用[J].实验动物科学与管理,2005,22(1):48-50.
[53]Zhang,D.-M.Phenolic Acidic Chemisriy,Chemical Industry Press,Beijing,2009:1.
[54]汪小全,邹喻苹,张大明,等.RAPD应用于遗传多样性和系统研究中的问题[J].植物学报,1996,38(12):954-962.
[55]Tautz D..Hyper variability of simple sequences as general sourcefor polymorphic DNA markers[J].Nucleic Acids Research,1989,17:6463-6471.
[56]Zhang,D.-M.Phenolic Acidic Chemisriy,Chemical Industry Press,Beijing,2009:1.
[57]Zabeau M.,and Vos P..Selective restriction fragment aplification a general method for DNA fingerprinting European Patent Amplifiaction 92402629.7(Publiction No.0534858AI).,Paris:European Patent Office,1993.
[58]田雷,曹鸣庆,王辉,等.AFLP标记技术在鉴定甘蓝种子真实性及品种纯度中的应用[J].生物技术通报,2001,14(03):38-40.
[59]王东升,周继磊,解荷峰,等.刺槐无性系遗传多样性的AFLP分析[J].西南林业学报,2012,32(06):26-29.
[60]王红霞,赵书岗,高仪,等.基于AFLP分子标志的核桃核心种质的构建[J].中国农业科学,2013,46(23):4985.
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