不同基础输液与儿科常用药加药前后不溶性微粒考察

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英文篇名：Investigation on the content of insoluble particles in different sodium chloride injection before and after compatible with pediatric medication 作者：李英 ; 关玮伟 ; 张英 ; 牛丽欣 ; 尉耘翠 ; 赵立波 ; 王晓玲 英文作者：LI Ying;GUAN Wei-wei;ZHANG Ying;NIU Li-xin;WEI Yun-cui;ZHAO Li-bo;WANG Xiao-ling;Department of Pharmacy, Beijing Children's Hospital, Capital Medical University,National Center for Children's Health;Department of Nursing, Beijing Children's Hospital, Capital Medical University,National Center for Children's Health;Clinical Research Center, Beijing Children's Hospital, Capital Medical University,National Center for Children's Health; 关键词：不溶性微粒 ; 输液 ; 光阻法 ; 儿科 英文关键词：insoluble particles;;sodium chloride injection;;light-blockage;;pediatric 中文刊名：中国临床药理学杂志 英文刊名：The Chinese Journal of Clinical Pharmacology 机构：国家儿童医学中心首都医科大学附属北京儿童医院药学部;国家儿童医学中心首都医科大学附属北京儿童医院护理部;国家儿童医学中心首都医科大学附属北京儿童医院临床研究中心; 出版日期：2019-07-28 出版单位：中国临床药理学杂志 年：2019 期：14 基金：吴阶平基金会科研专项课题基金资助项目(320.6750.18511) 语种：中文; 页：112-115 页数：4 CN：11-2220/R ISSN：1001-6821 分类号：R942

摘要

目的了解儿童常用药与不同基础输液配伍后不溶性微粒的差别,为临床输液产品的遴选提供依据。方法选取4种儿科临床常用的注射药品,以及北京地区市面上销售份额排名靠前的4家输液产品(内封式聚丙烯输液袋BFS,双层无菌软袋,单管软袋,双阀软袋,编号为输液A、B、C、D),分别测定空白输液及与4种药品(注射用阿奇霉素、注射用磷酸肌酸钠、复方甘草酸单铵S注射液、盐酸氨溴索注射液)分别配伍后的输液中,2μm以上全粒径范围的不溶性微粒数量,并进行组间比较。结果空白输液组间比较,输液A所含不溶性微粒数量最少,输液D所含不溶性微粒数量显著高于其他3种。相同药品与不同基础输液复配后比较,输液D显著高于其他3种输液;相同输液与不同药品复配后比较,药品1复配溶液所含不溶性微粒明显高于其他3种药品(P <0. 01)。计算复配后2～10μm不溶性微粒占比显示,小粒径微粒均占总体微粒数90%以上。结论不同输液产品与儿科常用药品复配后溶液中不溶性微粒数量具有显著差异,提示儿科临床需重视输液产品的遴选。
        Objective Foundation of select the pediatric drugs is provided by investigate the insoluble particles in different basic infusion.Methods Four kind of pediatric drugs( azithromycin for injection,sodium phosphocreatine for injection,compound ammonium glycyrrhetate S injection andambroxol hydrochloride injection) and four kinds of sodium chloride injection( BFS,double aseptic soft bag,single tube soft bag and double soft bag,numbered as infusion A,B,C,D),the sales volume of which were top 4 in Beijing were selected,and test the content of ≥2μm insoluble particles which per and post the different sodium chloride injection compatible with pediatric drugs. The content between different groups were compared. Results The content of insoluble particles in infusion A was the lowest in four kind of infusions,the number of infusion D was much higher than others before compatible with pediatric drugs.The content of insoluble particle in infusion which was matched with drug 1 was much higher than other groups( P < 0. 01). The content of 2-10μm insoluble particle was over 90% than total. Conclusion In this study,the outstanding difference was found that the content of insoluble particles in the different sodium chloride injection which was matched with pediatric drugs. It shows that it's necessary to pay attention to the selection of infusion in pediatrics.

引文

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