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Elsevier电子期刊(78)

在“Elsevier电子期刊”中，命中：78条，耗时：小于0.01 秒

在所有数据库中总计命中：78条

1.Michael acceptor containing drugs are a novel class of 5-lipoxygenase inhibitor targeting the surface cysteines C416 and C418

作者：Isabelle V. Maucher^a ; Michael Rü ; hl^a ; Simon B.M. Kretschmer^a ; Bettina Hofmann^a ; Benjamin Kü ; hn^a ; Jasmin Fettel^a ; Anja Vogel^a ; ^b ; Karsten T. Flü ; gel^a ; Georg Manolikakes^c ; Nadine Hellmuth^a ; Ann-Kathrin Hä ; fner^a ; Vahid Golghalyani^a ; Ann-Katrin Ball^a ; Matthias Piesche^d ; ^g ; Carmela Matrone^d ; Gerd Geisslinger^b ; ^e ; Michael J. Parnham^b ; Michael Karas^a ; Dieter Steinhilber^a ; Jessica Roos^a ; ¹ ; ^{roos@pharmchem.uni-frankfurt.de} ; Thorsten J. Maier^d ; ^f ; ¹ ; ^{maier@biomed.au.dk}

关键词：AA ; arachidonic acid ; methyl-BQ ; 2 ; 5-dimethyl-1 ; 4-benzoquinone ; CDDO ; CDDO-methylester ; methoxy-BQ ; 2 ; 3-dimethoxy-5-methyl-p-benzoquinone ; methoxy-NS ; 3-methoxy-β-nitrostyrene ; DMF ; dimethyl fumarate ; GSH ; glutathione ; OH-BQ ; 2 ; 5-dihydroxy-1 ; 4-benzoquinone ; HPLC ; high-performance liquid chromatography ; H(P)ETE ; hydro (peroxy-) eicosatetraenoic acid ; LT ; leukotrienes ; MS ; mass spectrometry ; NAC ; N-acetylcysteine ; NAPQI ; N-acetyl-p-benzoquinone imine ; NEM ; N-ethylmaleimide ; NFA ; nitro-fatty acid

刊名：Biochemical Pharmacology

出版年：2017

2.Activation of GR but not PXR by dexamethasone attenuated acetaminophen hepatotoxicities via Fgf21 induction

作者：Saurabh G. Vispute^a ; Pengli Bu^a ; ^b ; Yuan Le^a ; Xingguo Cheng^a ; ^{chengx@stjohns.edu}

关键词：APAP ; acetaminophen ; bp ; base pair ; ChIP ; chromatin immunoprecipitation ; Cyp ; cytochrome p450 enzyme ; DEX ; dexamethasone ; Fgf21 ; fibroblast growth factor 21 ; GR ; glucocorticoid receptor ; GRE ; glucocorticoid receptor response element ; GSH ; Glutathione ; i.p. ; intraperitoneal ; NAPQI ; N-acetyl-p-benzoquinone imine ; PGC1α ; peroxisome proliferator-activated receptor gamma coactivator protein-1α ; PPAR ; peroxisome proliferator-activated receptor ; PXR ; pregnane X receptor ; TSS ; transcription start site

刊名：Toxicology

出版年：2017

3.Acetaminophen-induced hepatotoxicity: Preventive effect of trans anethole

作者：Bruno Ambró ; sio da Rocha^a ; ^{brunoambrosiorocha@gmail.com} ; Alessandra M. Versuti Ritter^b ; ^{ale_mileni@hotmail.com} ; Franciele Queiroz Ames^a ; ^{francieleames@gmail.com} ; Odinei Hess Gonç ; alves^c ; ^{odinei@utfpr.edu.br} ; Fernanda Vitó ; ria Leimann^c ; ^{fernanda@utfpr.edu.br} ; Lí ; via Bracht^d ; ^{liviabracht@gmail.com} ; Maria Raquel Març ; al Natali^e ; ^{mrmnatali@uem.br} ; Roberto Kenji Nakamura Cuman^a ; Ciomar Ap. Bersani-Amado^a ; ^{cabamado@uem.br}

关键词：Trans anethole ; Acetaminophen ; Hepatoprotection

刊名：Biomedicine & Pharmacotherapy

出版年：2017

4.Caffeic acid prevents acetaminophen-induced liver injury by activating the Keap1-Nrf2 antioxidative defense system

作者：Chun Pang^a ; ^c ; ¹ ; Zhiyong Zheng^a ; ¹ ; Liang Shi^a ; Yuchen Sheng^b ; Hai Wei^c ; Zhengtao Wang^a ; Lili Ji^a ; ^{lichenyue1307@126.com" class="auth_mail" title="E-mail the corresponding author}

关键词：APAP ; acetaminophen ; DILI ; drug-induced liver injury ; CA ; Caffeic acid ; ALT/AST ; alanine/aspartate aminotransferases ; MPO ; myeloperoxidase ; GSH ; glutathione ; ROS ; reactive oxygen species ; Nrf2 ; nuclear factor erythroid 2-related factor 2 ; HO-1 ; heme oxygenase 1 ; NQO1 ; NAD(P)H ; quinone oxidoreductase 1 ; ZnPP ; zinc protoporphyrin ; Dim ; diminutol ; Keap1 ; kelch-like ECH-associated protein-1 ; CYP ; cytochrome P450 ; NAPQI ; N-acetyl-p-benzoquinone imine ; NAC ; N-acetylcysteine ; H2DCFDA ; 2ʹ-7ʹ-Dichlorodih

刊名：Free Radical Biology and Medicine

出版年：2016

5.Involvement of connexin43 in acetaminophen-induced liver injury

作者：Michaë ; l Maes^a ; Mitchell R. McGill^b ; ¹ ; Tereza Cristina da Silva^c ; Chloé ; Abels^d ; ^e ; Margitta Lebofsky^b ; Cintia Maria Monteiro de Araú ; jo^c ; Taynã ; Tiburcio^c ; Isabel Veloso Alves Pereira^c ; Joost Willebrords^a ; Sara Crespo Yanguas^a ; Anwar Farhood^f ; Alain Beschin^d ; ^e ; Jo A. Van Ginderachter^d ; ^e ; Maria Lucia Zaidan Dagli^c ; Hartmut Jaeschke^b ; Bruno Cogliati^c ; ² ; Mathieu Vinken^a ; ² ; ^{mvinken@vub.ac.be" class="auth_mail" title="E-mail the corresponding author}

关键词：ALT ; alanine aminotransferase ; APAP ; acetaminophen ; CD ; cluster of differentiation ; Cx ; connexin ; ELISA ; enzyme-linked immunosorbent assay ; GJIC ; gap junctional intercellular communication ; GSH ; glutathione ; GSSG ; glutathione disulfide ; hepaCAM ; hepatocyte cell adhesion molecule ; IFNγ ; interferon γ ; IL-1β/6/10 ; interleukin 1β/6/10 ; n ; number of repeats ; NAPQI ; N-acetyl-p-benzoquinone imine ; p ; probability ; RT-qPCR ; reverse transcription quantitative real-time polymerase chain reaction ; SEM ; stan

刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

出版年：2016

6.Transcriptome association analysis identifies miR-375 as a major determinant of variable acetaminophen glucuronidation by human liver

作者：Ioannis Papageorgiou^a ; ^{johnp@vetmed.wsu.edu" class="auth_mail" title="E-mail the corresponding author} ; Marina Freytsis^b ; ^{Marina.Freytsis@tufts.edu" class="auth_mail" title="E-mail the corresponding author} ; Michael H. Court^a ; ^{michael.court@vetmed.wsu.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：ALF ; acute liver failure ; NAPQI ; N-acetyl-p-benzoquinone imine ; UGT ; UDP-glucuronosyltransferase ; SULT ; sulfotransferase ; CYP ; cytochrome P450 ; 3&prime ; -UTR ; 3&prime ; -untranslated region ; SNP ; single nucleotide polymorphism ; miRNA ; microRNA ; UDPGA ; uridine diphosphate glucuronic acid ; qPCR ; quantitative real-time PCR ; AhR ; aryl hydrocarbon receptor ; MRE ; miRNA response element ; HNF1A ; hepatocyte nuclear factor 1-alpha ; HNF1B ; hepatocyte nuclear factor 1-beta ; Nrf2 ; nuclear factor erythroid 2-rel

刊名：Biochemical Pharmacology

出版年：2016

7.Non-cytotoxic concentrations of acetaminophen induced mitochondrial biogenesis and antioxidant response in HepG2 cells

作者：Tingfen Zhang^a ; Qiang Zhang^b ; Jiabin Guo^a ; Haitao Yuan^a ; Hui Peng^a ; Lan Cui^a ; Jian Yin^a ; Li Zhang^a ; Jun Zhao^a ; Jin Li^c ; Andrew White^c ; Paul L. Carmichael^c ; Carl Westmoreland^c ; Shuangqing Peng^a ; ^{pengsq@hotmail.com" class="auth_mail" title="E-mail the corresponding author}

关键词：APAP ; acetaminophen ; GSH ; glutathione ; LDH ; lactate dehydrogenase ; mtDNA ; mitochondrial DNA ; MPT ; mitochondrial permeability transition ; MnSOD ; manganese superoxide dismutase ; NAPQI ; N-acetyl-P-benzoquinoneimine ; ND1 ; nicotinamide adenine dinucleotide (NADH) dehydrogenase subunit 1 ; NRF-1 ; nuclear respiratory factor 1 ; Nrf2 ; nuclear erythroid-2 like factor-2 ; PGC-1α ; peroxisome proliferator-activated receptor γ coactivator-1α ; SIRT1 ; silentmating type-information regulation 2 homolog 1 ; ROS ; rea

刊名：Environmental Toxicology and Pharmacology

出版年：2016

8.The fungicide thiabendazole causes apoptosis in rat hepatocytes

作者：Marilyne Sé ; ï ; de^a ; ^b ; Michel Marion^a ; Mircea Alexandru Mateescu^a ; ^d ; Diana A. Averill-Bates^a ; ^b ; ^c ; ^d ; ^{averill.diana@uqam.ca" class="auth_mail" title="E-mail the corresponding author}

关键词：APAF-1 ; apoptosis protease activating factor-1 ; CYP ; cytochrome P450 ; DISC ; death inducing signaling complex ; EROD ; ethoxyresorufin-o-deethylase ; FADD ; Fas-associated death domain ; FBS ; fetal bovine serum ; FCCP ; carbonylcyanide p-trifluoromethoxyphenylhydrazone ; GAPDH ; glyceraldehyde-3-phosphate dehydrogenase ; HRP ; horseradish peroxidase ; LDH ; lactate dehydrogenase ; MTT ; methyl tetrazolium ; NAPQI ; N-acetyl-para-benzoquinone-imine ; PI ; propidium iodide ; PROD ; pentoxyresorufin-o-dealkylase ; PVDF

刊名：Toxicology in Vitro

出版年：2016

9.N-acetylcysteine amide, a promising antidote for acetaminophen toxicity

作者：Ahdab Khayyat^a ; Shakila Tobwala^a ; Marcia Hart^b ; Nuran Ercal^a ; ^{nercal@mst.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：GSH-prodrug ; Acetaminophen ; Hepatotoxicity ; Oxidative stress ; NAPQI ; Glutathione

刊名：Toxicology Letters

出版年：2016

10.Experimental models of hepatotoxicity related to acute liver failure

作者：Michaë ; l Maes^a ; Mathieu Vinken^a ; ¹ ; ^{mvinken@vub.ac.be" class="auth_mail" title="E-mail the corresponding author} ; Hartmut Jaeschke^b ; ¹

关键词：ALT ; alanine aminotransferase ; APAP ; acetaminophen ; ConA ; concanavalin A ; CYP ; cytochrome P450 ; ET ; endotoxin ; FasL ; Fas ligand ; Gal ; D-galactosamine ; GSH ; glutathione ; IFNγ ; interferon γ ; NAPQI ; N-acetyl-p-benzoquinone imine ; p-JNK ; c-jun N-terminal kinase activation ; TNFα ; tumor necrosis factor α

刊名：Toxicology and Applied Pharmacology

出版年：2016

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