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Elsevier电子期刊(36)

在“Elsevier电子期刊”中，命中：36条，耗时：0.0433034 秒

在所有数据库中总计命中：36条

1.Finite mixture of nonlinear mixed-effects joint models in the presence of missing and mismeasured covariate, with application to AIDS studies

作者：Xiaosun Lu ; Yangxin Huang ; ^{yhuang@health.usf.edu" class="auth_mail" title="E-mail the corresponding author} ; Yiliang Zhu

关键词：AIDS clinical trials ; Bayesian inference ; Finite mixture models ; NLME models ; Longitudinal data analysis

刊名：Computational Statistics & Data Analysis

出版年：2016

2.First-in-human application of the novel hepatitis B and hepatitis D virus entry inhibitor myrcludex B

作者：Antje Blank¹ ; ² ; ^{antje.blank@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author} ; Christoph Markert¹ ; Nicolas Hohmann¹ ; Alexandra Carls¹ ; Gerd Mikus¹ ; Thorsten Lehr³ ; Alexander Alexandrov⁴ ; Mathias Haag⁵ ; ⁶ ; ⁷ ; Matthias Schwab⁵ ; ⁶ ; ⁷ ; ⁸ ; Stephan Urban² ; ⁹ ; Walter E. Haefeli¹ ; ²

关键词：NTCP ; sodium taurocholate co-transporting polypeptide ; HBV ; hepatitis B virus ; CHB ; chronic hepatitis B ; HDV ; hepatitis D virus ; DSMB ; data and safety monitoring board ; MABEL ; minimal anticipated biologic effect level ; AE ; adverse event ; ECG ; electrocardiogram ; CTC-AE ; common terminology criteria for adverse events ; LOQ ; limit of quantification ; NCA ; non-compartmental analysis ; NLME ; nonlinear mixed effects ; OFV ; objective function value ; BMI ; body mass index ; VPC ; visual prediction check ; AUC

刊名：Journal of Hepatology

出版年：2016

3.Treatment of chronic hepatitis D with the entry inhibitor myrcludex B: First results of a phase Ib/IIa study

作者：Pavel Bogomolov¹ ; ² ; Alexander Alexandrov³ ; Natalia Voronkova¹ ; ² ; Maria Macievich¹ ; ² ; Ksenia Kokina¹ ; ² ; Maria Petrachenkova¹ ; ² ; Thorsten Lehr⁴ ; Florian A. Lempp⁵ ; ⁶ ; Heiner Wedemeyer⁷ ; Mathias Haag⁸ ; ⁹ ; ¹⁰ ; Matthias Schwab⁸ ; ⁹ ; ¹⁰ ; ¹¹ ; ¹² ; Walter E. Haefeli⁵ ; ¹³ ; Antje Blank⁵ ; ¹³ ; ^&dagger ; ; ^{antje.blank@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author} ; Stephan Urban⁵ ; ⁶ ; ^&dagger ;

关键词：ALT ; alanine aminotransferase ; AST ; aspartate aminotransferase ; BSA ; bovine serum albumin ; blq ; below limit of quantification ; cccDNA ; covalently closed circular deoxyribonucleic acid ; CHB ; chronic hepatitis B ; CHD ; chronic hepatitis D ; d ; hepatocyte death rate ; DNA ; deoxyribonucleic acid ; HBeAg ; HBe antigen ; HBsAg ; HBs antigen ; HBV ; hepatitis B virus ; HDV ; hepatitis D virus ; IFN ; interferon ; lod ; limit of detection ; loq ; limit of quantification ; NOEL ; no observed effect level ; NLME ; non-linear

刊名：Journal of Hepatology

出版年：2016

4.Uncertainty and variability in models of the cardiac action potential: Can we build trustworthy models?

作者：Ross H. Johnstone^a ; Eugene T.Y. Chang^b ; Ré ; mi Bardenet^c ; Teun P. de Boer^d ; David J. Gavaghan^a ; Pras Pathmanathan^e ; ¹ ; ^{pras.pathmanathan@fda.hhs.gov" class="auth_mail" title="E-mail the corresponding author} ; Richard H. Clayton^b ; ¹ ; ^{r.h.clayton@sheffield.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Gary R. Mirams^a ; ¹ ; ^{gary.mirams@cs.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author}

关键词：AP[D] ; Action Potential [Duration] ; CMA&ndash ; ES ; Covariance Matrix Adaptation&ndash ; Evolution Strategy ; GP ; Gaussian Process ; MCMC ; Markov Chain Monte Carlo ; NLME ; Non-Linear Mixed Effects ; TP06 ; the ten Tusscher et al. (2006) [45] action potential model ; UQ ; Uncertainty Quantification ; Vm ; trans-membrane Voltage ; VVUQ ; Verification ; Validation & Uncertainty Quantification

刊名：Journal of Molecular and Cellular Cardiology

出版年：2016

5.Estimating the variability in fraction absorbed as a paradigm for informing formulation development in early clinical drug development

作者：Sarit Cohen Rabbie^a ; ^{sarit.rabbie@astrazeneca.com" class="auth_mail" title="E-mail the corresponding author} ; Paul D. Martin^b ; Talia Flanagan^b ; Abdul W. Basit^a ; Joseph F. Standing^c

关键词：F ; Bioavailability ; fa ; fraction absorbed ; fg ; fraction passing the gut wall ; fh ; fraction escaping hepatic metabolism ; GI ; gastrointestinal ; NLME ; nonlinear mixed effect modelling ; IR ; immediate release ; PR ; prolonged release ; ICH ; international conference on harmonisation ; GCP ; good clinical practice ; CLR ; renal clearance ; CLH ; hepatic clearance ; WT ; weight ; FQ ; liver blood flow ; BPR ; blood/plasma ratio ; CLi ; intrinsic clearance ; LV ; liver volume ; ER ; extraction ratio ; FOCE ; first order condit

刊名：European Journal of Pharmaceutical Sciences

出版年：2016

6.Population pharmacokinetics meets microdialysis: Benefits, pitfalls and necessities of new analysis approaches for human microdialysis data

作者：André ; Schaeftlein^a ; ^b ; Iris K. Minichmayr^a ; ^b ; Charlotte Kloft^a ; ^{charlotte.kloft@fu-berlin.de" class="auth_mail}

关键词：Microdialysis ; Humans ; Data analysis ; NLME ; PBPK ; Population PBPK

刊名：European Journal of Pharmaceutical Sciences

出版年：16 June 2014

7.Pharmacokinetic/pharmacodynamic modelling approaches in paediatric infectious diseases and immunology

作者：Charlotte I.S. Barker^a ; ^b ; Eva Germovsek^b ; Rollo L. Hoare^b ; ^c ; Jodi M. Lestner^a ; ^d ; Joanna Lewis^b ; ^c ; Joseph F. Standing^b ; ^c ; ^{j.standing@ucl.ac.uk" class="auth_mail}

关键词：Pharmacokinetics/pharmacodynamics (PKPD) ; Non-linear mixed effects (NLME) ; Paediatrics ; Antimicrobial ; Antibacterial ; Antifungal ; Antiviral (and antiretrovirals) ; HIV viral and T-cell dynamics ; Immune reconstitution

刊名：Advanced Drug Delivery Reviews

出版年：30 June 2014

8.Parameter estimation of two-level nonlinear mixed effects models using first order conditional linearization and the EM algorithm

作者：Liyong Fu ; Mingliang Wang ; Yuancai Lei ; Shouzheng Tang

关键词：Cunninghamia lanceolata ; Expectation&ndash ; maximization algorithm ; First order conditional expansion ; Lindstrom and Bates algorithm ; Simulated data ; Two-level nonlinear mixed effects models

刊名：Computational Statistics and Data Analysis

出版年：2014

9.Modelling tree height-diameter relationships in multi-species and multi-layered forests: A large observational study from Northeast China

作者：H. Temesgen ; C.H. Zhang ; X.H. Zhao

关键词：Vegetation resources inventory ; Northeast China ; Allometry

刊名：Forest Ecology and Management

出版年：15 March, 2014

10.Bayesian inference in nonlinear mixed-effects models using normal independent distributions

作者：Victor H. Lachos^a ; ^{hlachos@ime.unicamp.br} ; Luis M. Castro^b ; Dipak K. Dey^c

关键词：Gibbs algorithms ; MCMC ; Metropolis&ndash ; Hastings ; Nonlinear mixed-effects models ; Normal/independent distributions

刊名：Computational Statistics and Data Analysis

出版年：2013

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