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Elsevier电子期刊(17)

在“Elsevier电子期刊”中，命中：17条，耗时：0.040984 秒

在所有数据库中总计命中：82条

1.Mapping the Binding Site of BMS-708163 on γ-Secretase with Cleavable Photoprobes

作者：Natalya Gertsik¹ ; ² ; Christopher W. am Ende³ ; Kieran F. Geoghegan⁴ ; Chuong Nguyen⁴ ; Paramita Mukherjee³ ; Scot Mente⁵ ; Uthpala Seneviratne⁵ ; Douglas S. Johnson⁵ ; ^{doug.johnson@pfizer.com} ; Yue-Ming Li¹ ; ⁶ ; ⁷ ; ^{liy2@mskcc.org}

关键词：Alzheimer's disease ; cleavable linkers ; photoaffinity labeling ; peptide mapping ; molecular dynamics simulations

刊名：Cell Chemical Biology

出版年：2017

2.Presenilin 1 mutations influence processing and trafficking of the ApoE receptor apoER2

作者：Wei Wang^a ; ¹ ; Andrea M. Moerman-Herzog^a ; ² ; Arthur Slaton^a ; Steven W. Barger^a ; ^b ; ^c ; ^{bargerstevenw@uams.edu}

关键词：Alzheimer's disease ; ApoER2 ; γ-Secretase ; Lipoprotein receptor ; Presenilin ; Protein processing ; Protein trafficking

刊名：Neurobiology of Aging

出版年：2017

3.Design and synthesis of water soluble β-aminosulfone analogues of SCH 900229 as γ-secretase inhibitors

作者：Wen-Lian Wu^a ; ; Duane A. Burnett^a ; John Clader^a ; William J. Greenlee^a ; Qin Jiang^b ; Lynn A. Hyde^a ; Robert A. Del Vecchio^a ; Mary E. Cohen-Williams^a ; Lixin Song^a ; Julie Lee^a ; Giuseppe Terracina^a ; Qi Zhang^a ; Amin Nomeir^a ; Eric M. Parker^a ; Lili Zhang^a

关键词：AD ; Alzheimer&rsquo ; s disease ; Aβ ; β-amyloid ; PS1 ; presenilin-1 ; PS2 ; presenilin-2 ; APP ; amyloid precursor protein ; GSI ; γ-secretase inhibitor ; SAR ; structure&ndash ; activity relationship ; ADME ; absorption ; distribution ; metabolism ; and excretion ; AUC ; area under curve ; mCPBA ; m-chloroperbenzoic acid

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

4.Substituted 4-morpholine N-arylsulfonamides as γ-secretase inhibitors

作者：Zhiqiang Zhao^a ; ^{zhiqiang.zhao@merck.com" class="auth_mail" title="E-mail the corresponding author} ; Dmitri A. Pissarnitski^a ; Hubert B. Josien^a ; Thomas A. Bara^a ; John W. Clader^a ; Hongmei Li^a ; Mark D. McBriar^a ; Murali Rajagopalan^a ; Ruo Xu^a ; Giuseppe Terracina^b ; Lynn Hyde^b ; Lixin Song^b ; Lili Zhang^b ; Eric M. Parker^b ; Rebecca Osterman^c ; Alexei V. Buevich^c

关键词：γ-secretase inhibitor ; Alzheimer's disease ; substituted 4-morpholine sulfonamide

刊名：European Journal of Medicinal Chemistry

出版年：2016

5.Pharmacological properties of a novel and potent γ-secretase modulator as a therapeutic option for the treatment of Alzheimer’s disease

作者：Koji Murakami^a ; Tomomichi Watanabe^a ; Tatsuki Koike^a ; Makoto Kamata^a ; Tomoko Igari^b ; Shinichi Kondo^a ; ^{shinichi.kondou@takeda.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Aβ ; Amyloid-β ; AD ; Alzheimer&rsquo ; s disease ; APP ; Amyloid precursor protein ; β-CTF ; β-C-terminal fragment ; BACE ; β-site APP-cleaving enzyme ; CSF ; Cerebrospinal fluid ; ELISA ; Enzyme-linked immunosorbent assay ; FBS ; Fetal bovine serum ; GSI ; γ-secretase inhibitor ; GSM ; γ-secretase modulator ; LC/MS/MS ; Liquid chromatography-tandem mass spectrometry ; N2a-APPsw ; Neuro-2a mouse neuroblastoma cells stably expressing human Swedish mutant APP ; NFT ; Neurofibrillary tangle ; NORT ; Novel object recognition t

刊名：Brain Research

出版年：2016

6.Combination with γ-secretase inhibitor prolongs treatment efficacy of BRAF inhibitor in BRAF-mutated melanoma cells

作者：Guannan Zhu^a ; ^b ; Xiuli Yi^a ; Sebastian Haferkamp^c ; Sonja Hesbacher^b ; Chunying Li^a ; Matthias Goebeler^b ; Tianwen Gao^a ; ^{gaotw@fmmu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Roland Houben^b ; ¹ ; David Schrama^b ; ¹ ; ^{schrama_d@ukw.de" class="auth_mail" title="E-mail the corresponding author}

关键词：Melanoma ; Notch ; Senescence ; BRAF inhibition

刊名：Cancer Letters

出版年：2016

7.Paradoxical E-cadherin increase in 5FU-resistant colon cancer is unaffected during mesenchymal-epithelial reversion induced by γ-secretase inhibition

作者：Simona Dinicola^a ; ^b ; Alessia Pasqualato^c ; Sara Proietti^a ; ^b ; Maria Grazia Masiello^a ; ^b ; Alessandro Palombo^b ; ^d ; Pierpaolo Coluccia^b ; ^c ; Rita Canipari^e ; Angela Catizone^e ; Giulia Ricci^f ; Abdel Halim Harrath^g ; Saleh H. Alwasel^g ; Alessandra Cucina^b ; ^c ; Mariano Bizzarri^d ; ^h ; ¹ ; ^{mariano.bizzarri@uniroma1.it" class="auth_mail" title="E-mail the corresponding author}

关键词：Presenilin-1 ; γ-Secretase activity ; SNAI1 ; Chemoresistance ; E-cadherin ; EMT

刊名：Life Sciences

出版年：2016

8.Single administration of a novel γ-secretase modulator ameliorates cognitive dysfunction in aged C57BL/6J mice

作者：Tatsuya Hayama^a ; Koji Murakami^a ; Tomomichi Watanabe^a ; Ryota Maeda^a ; Makoto Kamata^a ; Shinichi Kondo^a ; ^{shinichi.kondou@takeda.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Aβ ; β-amyloid ; ACSF ; artificial cerebrospinal fluid ; AD ; Alzheimer׳s disease ; APP ; amyloid precursor protein ; Ca2+ ; calcium ion ; CTF ; C terminal fragment ; DKO ; double knockout ; DMSO ; dimethyl sulfoxide ; ER ; endoplasmic reticulum ; FAD ; familial early-onset Alzheimer׳s disease ; fEPSP ; field excitatory postsynaptic potential ; GSI ; γ-secretase inhibitor ; GSM ; γ-secretase modulator ; LTP ; long-term potentiation ; MCI ; mild cognitive impairment ; MEF ; mouse embryonic fibroblast ; mRNA ; messenger RNA ; NORT

刊名：Brain Research

出版年：2016

9.The role of Notch signaling in diabetic endothelial progenitor cells dysfunction

关键词：Notch signaling pathway ; Endothelial progenitor cells ; Diabetes ; γ-Secretase inhibitor ; Vasculogenesis

刊名：Journal of Diabetes and its Complications

出版年：2016

10.Sequential combination therapy of ovarian cancer with cisplatin and γ-secretase inhibitor MK-0752

作者：XiuXiu Chen^a ; ¹ ; LiHua Gong^a ; ¹ ; RongYing Ou^a ; ZhenZhen Zheng^a ; JinYan Chen^a ; FengFeng Xie^a ; XiaoXiu Huang^a ; JianGe Qiu^b ; WenJi Zhang^b ; QiWei Jiang^b ; Yang Yang^b ; Hua Zhu^a ; Zhi Shi^b ; ^{tshizhi@jnu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; XiaoJian Yan^a ; ^{yxjbetter@126.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Ovarian cancer ; MK-0752 ; Cisplatin ; Combination therapy

刊名：Gynecologic Oncology

出版年：2016

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