作者：Anju Singh ; Mudasir Maqbool ; Mohammad Mobashir ; Nasimul Hoda ; ^{nhoda@jmi.ac.in}

关键词：Malaria ; Dihydroorotate dehydrogenase (DHODH) ; Pyrimidine biosynthesis ; Plasmodium parasite ; Drug resistance

刊名：European Journal of Medicinal Chemistry

出版年：2017

作者：Luí ; s Felipe S.P. Azeredo^a ; ^b ; Julia P. Coutinho^c ; ^d ; Valquiria A.P. Jabor^e ; Patricia R. Feliciano^e ; Maria Cristina Nonato^e ; Carlos R. Kaiser^b ; Carla Maria S. Menezes^a ; Amanda S.O. Hammes^f ; Ernesto Raul Caffarena^f ; Lucas V.B. Hoelz^a ; Nicolli B. de Souza^c ; Glaé ; cia A.N. Pereira^c ; Isabela P. Cerá ; volo^c ; Antoniana U. Krettli^c ; ^d ; Nubia Boechat^a ; ^b ; ^{boechat@far.fiocruz.br}

关键词：Malaria ; P. falciparum ; Pyrazolo[1 ; 5-a]pyrimidine ; Dihydroorotate dehydrogenase (DHODH) ; Molecular docking

刊名：European Journal of Medicinal Chemistry

出版年：2017

作者：Daniel Ken Inaoka^a ; ^b ; Maiko Iida^c ; Satoshi Hashimoto^c ; Toshiyuki Tabuchi^c ; Takefumi Kuranaga^c ; Emmanuel Oluwadare Balogun^a ; Teruki Honma^d ; Akiko Tanaka^d ; Shigeharu Harada^e ; Takeshi Nara^f ; Kiyoshi Kita^a ; ^b ; Masayuki Inoue^c ; ^{inoue@mol.f.u-tokyo.ac.jp}

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

作者：David B. Sykes¹ ; ² ; ¹¹ ; ¹² ; ¹⁵ ; ^{dbsykes@mgh.harvard.edu" class="auth_mail" title="E-mail the corresponding author} ; Youmna S. Kfoury¹ ; ¹¹ ; ¹² ; Franç ; ois E. Mercier¹ ; ¹¹ ; ¹² ; Mathias J. Wawer³ ; Jason M. Law⁴ ; ¹³ ; Mark K. Haynes⁵ ; Timothy A. Lewis⁴ ; Amir Schajnovitz¹ ; ¹¹ ; ¹² ; Esha Jain¹ ; Dongjun Lee¹ ; ¹¹ ; ¹² ; Hanna Meyer⁶ ; Kerry A. Pierce⁷ ; Nicola J. Tolliday³ ; Anna Waller⁵ ; Steven J. Ferrara³ ; Ashley L. Eheim⁶ ; Detlef Stoeckigt⁶ ; Katrina L. Maxcy¹ ; Julien M. Cobert¹ ; Jacqueline Bachand¹ ; Brian A. Szekely¹ ; Siddhartha Mukherjee⁸ ; Larry A. Sklar⁵ ; Joanne D. Kotz⁴ ; Clary B. Clish⁷ ; Ruslan I. Sadreyev⁹ ; ¹⁰ ; Paul A. Clemons⁴ ; Andreas Janzer⁶ ; Stuart L. Schreiber⁴ ; ¹³ ; ¹⁴ ; David T. Scadden¹ ; ² ; ¹¹ ; ¹² ; ^{dscadden@mgh.harvard.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：acute myeloid leukemia ; differentiation ; HoxA9 ; high-throughput screen ; phenotypic screen ; leukemia-initiating cell ; dihydroorotate dehydrogenase ; brequinar ; metabolic inhibitor

刊名：Cell

出版年：2016

作者：Ivá ; n Caballero^a ; Marí ; a José ; Lafuente^b ; Francisco-Javier Gamo^b ; Concepció ; n Cid^a ; ^{concha.cid@gsk.com" class="auth_mail" title="E-mail the corresponding author} ; ^{conchacidcalzada@gmail.com" class="auth_mail" title="E-mail the corresponding author}

关键词：DHODH ; Resazurin ; Fluorescence ; Assay development ; HTS ; Malaria

刊名：Analytical Biochemistry

出版年：2016

作者：John A. Duley^a ; ^{jduley@pharmacy.uq.edu.au" class="auth_mail" title="E-mail the corresponding author} ; Michael G. Henman^b ; ^{michael.henman@mater.org.au" class="auth_mail" title="E-mail the corresponding author} ; Kevin H. Carpenter^c ; ^{kevin.carpenter@health.nsw.gov.au" class="auth_mail" title="E-mail the corresponding author} ; Michael J. Bamshad^d ; ^{mbamshad@u.washington.edu" class="auth_mail" title="E-mail the corresponding author} ; George A. Marshall^e ; ^{george.marshall@mater.org.au" class="auth_mail" title="E-mail the corresponding author} ; Chee Y. Ooi^f ; ⁱ ; ^{keith.ooi@unsw.edu.au" class="auth_mail" title="E-mail the corresponding author} ; Bridget Wilcken^g ; ^{bridget.wilcken@health.nsw.gov.au" class="auth_mail" title="E-mail the corresponding author} ; Jason R. Pinner^h ; ^{jason.pinner@sswahs.nsw.gov.au" class="auth_mail" title="E-mail the corresponding author}

关键词：AST ; aspartate transaminase ; ALT ; alanine transaminase ; CYP ; cytochrome-P450 ; Cyt C ; cytochrome C ; DHO ; dihydroorotic acid ; DHODH ; DHO dehydrogenase ; EDTA ; ethylenediamine-tetraacetic acid ; FMN ; flavin mononucleotide ; GGT ; gamma-glutamyl transferase ; LC-MS/MS ; high performance liquid chromatography-tandem mass spectrometry ; OA ; orotic acid ; POADS ; post-axial acrofacial dysostosis ; UMP ; uridine monophosphate ; UQH2 ; reduced ubiquinone

刊名：Molecular Genetics and Metabolism

出版年：2016

作者：Bruno C. Marreiros ; Filipa Calisto ; Paulo J. Castro ; Afonso M. Duarte ; Filipa V. Sena ; Andreia F. Silva ; Filipe M. Sousa ; Miguel Teixeira ; Patrí ; cia N. Refojo ; Manuela M. Pereira ; ^{mpereira@itqb.unl.pt" class="auth_mail" title="E-mail the corresponding author}

关键词：ACIII ; Alternative Complex III ; ADH ; Alcohol dehydrogenase ; ALDH ; Aldehyde dehydrogenase ; AMO ; Ammonia monooxygenase ; AOX ; Alternative oxidase ; CISM ; Complex Iron-Sulfur Molybdoenzyme ; DAADH ; d-amino acid dehydrogenase ; DHODH ; dihydroorotate dehydrogenase ; DmsABC ; DMSO reductase ; DMSO ; dimethyl sulfoxide ; Dsr ; dissimilatory sulfite reductase ; ETF-QO ; electron transfer flavoprotein ; quinone oxidoreductase ; Fdn-N ; Formate dehydrogenase-N ; GADH ; d-glyceraldehyde dehydrogenase ; GLDH ; Glycerol dehydro

刊名：Biochimica et Biophysica Acta (BBA) - Bioenergetics

出版年：2016

作者：Raquel Moreno-Loshuertos^b ; José ; Antonio Enrí ; quez^a ; ^b ; ^{jaenriquez@cnic.es" class="auth_mail" title="E-mail the corresponding author}

关键词：BN-PAGE ; blue native polyacrylamide gel electrophoresis ; CI to CV ; complex I to complex V ; CoQ ; coenzyme Q ; cyt c ; cytochrome c ; DHODH ; dihydroorotate dehydrogenase ; G3PDH ; glycerol-3-phosphate dehydrogenase ; IMM ; inner mitochondrial membrane ; LOM ; loss of memory ; mETC ; mitochondrial electron transport chain ; OXPHOS ; oxidative phosphorylation ; PE ; phosphatidylethanolamine ; ROS ; reactive oxygen species ; SC ; supercomplex ; SCAF1 ; supercomplex assembly factor 1 ; SDH ; succinate dehydrogenase ; TEM ; tr

刊名：Free Radical Biology and Medicine

出版年：2016

作者：Gowtham Subramanian^a ; ^&dagger ; ; C.P. Babu Rajeev^b ; ^&dagger ; ; Chakrabhavi Dhananjaya Mohan^c ; Ameya Sinha^a ; Trang T.T. Chu^a ; Sebastian Anusha^b ; Huang Ximei^d ; Julian E. Fuchs^e ; ^f ; Andreas Bender^e ; Kanchugarakoppal S. Rangappa^c ; Rajesh Chandramohanadas^a ; ^{rajesh@sutd.edu.sg" class="auth_mail" title="E-mail the corresponding author} ; Basappa^b ; ^{salundibasappa@gmail.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Hydralazines ; Antimalarials ; Dihydroorotate dehydrogenase ; P. falciparum ; Bronsted acidic ionic liquids

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

作者：Clé ; ment Grandin^a ; ^b ; ^c ; ¹ ; Marianne-Lucas Hourani^b ; ^c ; ¹ ; Yves L. Janin^d ; ^e ; Daniel Dauzonne^f ; ^g ; ^h ; Hé ; lè ; ne Munier-Lehmann^d ; ^e ; Adeline Paturet^a ; Fabrice Taborik^a ; Astrid Vabretⁱ ; Hugues Contamin^a ; ^{hugues.contamin@cynbiose.com" class="auth_mail" title="E-mail the corresponding author} ; Fré ; dé ; ric Tangy^b ; ^c ; ^{frederic.tangy@pasteur.fr" class="auth_mail" title="E-mail the corresponding author} ; Pierre-Olivier Vidalain^b ; ^c ; ^{pierre-olivier.vidalain@parisdescartes.fr" class="auth_mail" title="E-mail the corresponding author}

关键词：Cynomolgus macaques ; Respiratory syncytial virus ; Pyrimidine biosynthesis inhibitors ; Antiviral compounds ; Dihydroorotate dehydrogenase

刊名：Antiviral Research

出版年：2016