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Wiley电子期刊(13)	ProQuest学位论文(2)	Elsevier电子期刊(696)
SpringerLink电子期刊(187)	NATURE电子期刊(24)	ACS电子期刊(208)

在“Elsevier电子期刊”中，命中：696条，耗时：0.0539399 秒

在所有数据库中总计命中：1,130条

1.Drug discovery targeting heme-based sensors and their coupled activities

作者：Eduardo Henrique Silva Sousa^a ; ^{eduardohss@dqoi.ufc.br} ; Luiz Gonzaga de Franç ; a Lopes^a ; Gonzalo Gonzalez^b ; Marie-Alda Gilles-Gonzalez^b ; ^{marie-alda.gilles-gonzalez@utsouthwestern.edu}

关键词：Drug discovery ; Heme-based sensor ; Nucleotide cyclase ; Phosphodiesterase ; Histidine protein kinase ; Nuclear receptor

刊名：Journal of Inorganic Biochemistry

出版年：2017

2.Mitigation of reactive metabolite formation for a series of 3-amino-2-pyridone inhibitors of Bruton’s tyrosine kinase (BTK)

作者：Yan Lou ; ^{yan.lou@gmail.com} ; Francisco Lopez ; Yongying Jiang ; Xiaochun Han ; Chris Brotherton ; Roland Billedeau ; Steve Gabriel ; Shelly Gleason ; David M. Goldstein ; Ramona Hilgenkamp ; Buelent Kocer ; Lucja Orzechowski ; Jenny Tan ; Peter Wovkulich ; Bo Wen ; David Fry ; Paola Di Lello ; Lucy Chen ; Fang-jie Zhang ; Jennifer Fretland ; Anjali Nangia ; Tian Yang ; Timothy D. Owens

关键词：Bruton&rsquo ; s tyrosine kinase ; BTK ; Reactive metabolite ; Covalent binding ; Glutathione adduct

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

3.The marine-derived pachycladin diterpenoids as novel inhibitors of wild-type and mutant EGFR

作者：Mohamed M. Mohyeldin ^{mohyelmm@warhawks.ulm.edu} ; Mohamed R. Akl ^{mohamedreda_pharmacy@yahoo.com} ; Abu Bakar Siddique ; Hossam M. Hassan¹ ; ^{abuh20050@yahoo.com} ; Khalid A. El Sayed ; ^{elsayed@ulm.edu}

关键词：ATCC ; American type culture collection ; CD30 ; cluster of differentiation 30 a type I transmembrane glycoprotein belonging to the TNF receptor superfamily ; CD31 ; platelet endothelial cell adhesion molecule 1 ; EGF ; epidermal growth factor ; EPHB4 ; ephrin type-B receptor 4 ; ERK ; extracellular signal-regulated kinase ; FGFR ; fibroblast growth factor receptor ; FLT3 ; fms-related tyrosine kinase 3 ; JAK2 ; janus kinase 2 ; L858R ; leucine 858 mutated to arginine ; L861Q ; leucine 861 mutated to glutamine ; M ; m

刊名：Biochemical Pharmacology

出版年：2017

4.Identification of allosteric binding sites for PI3Kα oncogenic mutant specific inhibitor design

作者：Michelle S. Miller^a ; Sweta Maheshwari^b ; Fiona M. McRobb^c ; Kenneth W. Kinzler^d ; L. Mario Amzel^b ; Bert Vogelstein^d ; Sandra B. Gabelli^a ; ^b ; ^e ; ^{gabelli@jhmi.edu}

关键词：PIK3CA ; PI3K ; PIP2 ; PIP3 ; Fragment-based drug discovery

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

5.Exploiting receptor tyrosine kinase co-activation for cancer therapy

作者：Aik-Choon Tan¹ ; ^{aikchoon.tan@ucdenver.edu}Author Vitae ; Simon Vyse²Author Vitae ; Paul H. Huang² ; ^{paul.huang@icr.ac.uk}Author Vitae

刊名：Drug Discovery Today

出版年：2017

6.Emerging drug resistance in Plasmodium falciparum: A review of well-characterized drug targets for novel antimalarial chemotherapy

作者：Arnish Chakraborty ; ^{arnish@icgeb.res.in" class="auth_mail" title="E-mail the corresponding author}

关键词：Malaria ; Drug targets ; Antimalarial ; Drug resistance ; Plasmodium falciparum ; Protein kinases

刊名：Asian Pacific Journal of Tropical Disease

出版年：2016

7.Pharmacological modulation of oncogenic Ras by natural products and their derivatives: Renewed hope in the discovery of novel anti-Ras drugs

作者：Shun Ying Quah^a ; ¹ ; Michelle Siying Tan^a ; ¹ ; Yuan Han Teh^a ; ¹ ; Johnson Stanslas^a ; ^b ; ^{rcxjs@upm.edu.my" class="auth_mail" title="E-mail the corresponding author} ; ^{jstanslas@yahoo.co.uk" class="auth_mail" title="E-mail the corresponding author}

关键词：AGP ; Andrographolide ; APT1 ; Acyl protein thioesterase 1 ; COX-2 ; cyclooxygenase-2 ; DPI ; Dual prenylation inhibitor ; ERK ; Extracellular signal-regulated kinase ; FBDD ; Fragment-based drug discovery ; FTase ; Farnesyltransferase ; FTIs ; Farnesyltransferase inhibitors ; G12 ; Glycine-12 ; G13 ; Glycine-13 ; Q61 ; Glutamine-61 ; GAP ; GTPase-activating protein ; GDP ; Guanosine diphosphate ; GEF ; Guanine nucleotide exchange factor ; GGTase I ; Geranylgeranyltransferase I ; GGTI ; Geranylgeranyltransferase inhibitor ; GT

刊名：Pharmacology and Therapeutics

出版年：2016

8.Discovery of TAK-659 an orally available investigational inhibitor of Spleen Tyrosine Kinase (SYK)

作者：Betty Lam^a ; ^{betty.lam@takeda.com} ; Yasuyoshi Arikawa^b ; Joshua Cramlett^c ; Qing Dong^d ; Ron de Jong^a ; Victoria Feher^e ; Charles E. Grimshaw^a ; Pamela J. Farrell^a ; Isaac D. Hoffman^a ; Andy Jennings^a ; Benjamin Jones^a ; Jennifer Matuszkiewicz^f ; Joanne Miura^a ; Hiroshi Miyake^b ; Srinivasa Reddy Natala^g ; Lihong Shi^f ; Masashi Takahashi^b ; Ewan Taylor^a ; Corey Wyrick^a ; Jason Yano^h ; Jonathan Zalevskyⁱ ; Zhe Nie^f

关键词：SYK ; Kinase inhibitor ; Kinase selectivity ; Structure-based drug discovery ; Leukemia ; Lymphoma

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

9.Three stories on Eph kinase inhibitors: From in silico discovery to in vivo validation

作者：Andrea Unzue^a ; ⁶ ; Karine Lafleur^a ; ¹ ; ⁶ ; Hongtao Zhao^b ; ² ; ⁶ ; Ting Zhou^b ; ³ ; Jing Dong^b ; ⁴ ; Peter Kolb^b ; ⁵ ; Johanna Liebl^c ; Stefan Zahler^c ; Amedeo Caflisch^b ; ^{caflisch@bioc.uzh.ch" class="auth_mail" title="E-mail the corresponding author} ; Cristina Nevado^a ; ^{cristina.nevado@chem.uzh.ch" class="auth_mail" title="E-mail the corresponding author}

关键词：Drug discovery ; EphB4 ; In silico ; Kinase ; Potency ; Selectivity

刊名：European Journal of Medicinal Chemistry

出版年：2016

10.Discovery and structure activity relationship study of novel indazole amide inhibitors for extracellular signal-regulated kinase1/2 (ERK1/2)

作者：Lei Li^a ; ^&dagger ; ; Feifei Liu^b ; ^&dagger ; ; Nan Jin^b ; Shuai Tang^b ; Zhuxi Chen^a ; ^b ; Xiaotong Yang^b ; Jian Ding^b ; Meiyu Geng^b ; Lei Jiang^a ; Min Huang^b ; ; Jianhua Cao^a ;

关键词：ERK1/2 kinase inhibitor ; Indazole amide ; Structure based drug design

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

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