搜索页_+Molecular+Operating+Environment

设为首页

收藏本站

网站地图 | English | 公务邮箱

读者指南

学术客户端

NSTL服务站

科技查新

外文资源

Wiley电子期刊(4)	ProQuest学位论文(2)	Elsevier电子期刊(210)
SpringerLink电子期刊(104)	NATURE电子期刊(4)	ACS电子期刊(36)

在“Elsevier电子期刊”中，命中：210条，耗时：0.180915 秒

在所有数据库中总计命中：360条

1.Diversity selection, screening and quantitative structure-activity relationships of osmolyte-like additive effects on the thermal stability of a monoclonal antibody

作者：Olubukayo-Opeyemi Oyetayo^a ; ^{oyetayophdhbc@gmail.com} ; Oscar Mé ; ndez-Lucio^b ; Andreas Bender^b ; Hans Kiefer^a

关键词：mAb ; Monoclonal antibody ; MOE ; Molecular Operating Environment ; MDS ; Multi-dimensional scaling ; QSAR ; Quantitative structure&ndash ; activity relationship ; DSC ; Differential scanning calorimetry ; DSF ; Differential scanning fluorimetry ; DMSO ; Dimethyl sulfoxide ; NaOH ; Sodium hydroxide ; HCl ; Hydrochloric acid ; LOO-CV ; Leave-one-out cross-validation ; PCA ; Principal components analysis ; PLS ; Partial least squares ; TMAO ; Trimethylamine N-oxide ; Tm ; Melting temperature ; TS potency ; Thermal stabilization

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

2.Computational study of some amoebicidal phytochemicals against heat shock protein of Naegleria fowleri

作者：Zarrin Basharat ; ^{zarrin.iiui@gmail.com} ; Shumaila Zaib ; Azra Yasmin

关键词：Hsp ; heat shock protein ; PAM ; primary amoebic meningoencephalitis ; MOE ; molecular Operating Environment ; EGCG ; (&minus ; )-epigallocatechin gallate

刊名：Gene Reports

出版年：2017

3.Extensive deamidation of RNase A inhibits its oligomerization through 3D domain swapping

关键词：RNase A ; bovine pancreatic ribonuclease A ; ND ; N-term-swapped RNase A dimer ; CD ; C-term-swapped RNase A ; NaPi ; sodium phosphate buffer ; CD ; circular dichroism ; 3D&ndash ; DS ; three dimensional domain swapping ; N67D-RNase A ; Asp67 derivative ; N67D-RNase A ; isoAsp67 derivative ; X ; (deamidated) impurity RNase A type I-A species ; dd ; poly-deamidated-induced RNase A derivatives ; BSA ; bovine serum albumin ; MOE ; Molecular Operating Environment

刊名：Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

出版年：2017

4.Zinc-mediated binding of a low-molecular-weight stabilizer of the host anti-viral factor apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G

作者：Mohamed O. Radwan^a ; Sachiko Sonoda^a ; Tomohiko Ejima^a ; Ayumi Tanaka^a ; Ryoko Koga^a ; Yoshinari Okamoto^a ; Mikako Fujita^b ; ^{mfujita@kumamoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Masami Otsuka^a ; ^{motsuka@gpo.kumamoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author}

关键词：APOBEC3G ; Host anti-viral factor ; HIV ; Zinc ; Biotin&ndash ; avidin technology ; Molecular docking

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

5.Therapeutic potential of Taraxacum officinale against HCV NS5B polymerase: In-vitro and In silico study

作者：Sidra Rehman^a ; ^{sidrarehman@ciit.net.pk" class="auth_mail" title="E-mail the corresponding author} ; ^{sidra.cemb@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Bushra Ijaz^b ; Nighat Fatima^c ; Syed Aun Muhammad^d ; Sheikh Riazuddin^e

关键词：HCV ; Hepatitis C virus ; TM ; Taraxacum Officinale ; MOE ; Molecular operator Environment ; Huh-7 ; Human Hepatoma cell line ; CHO ; Chinese Hamster Ovarian cells

刊名：Biomedicine & Pharmacotherapy

出版年：2016

6.NQO1 rs1800566 polymorph is more prone to NOx induced lung injury: Endorsing deleterious functionality through informatics approach

作者：Zarrin Basharat^a ; ^{zarrin.iiui@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Abdelmonaem Messaoudi^b ; Sehrish Ruba^c ; Azra Yasmin^a

关键词：WT ; Wild type ; NQO1 ; NAD(P)H ; quinone oxidoreductase 1 ; RMSD ; Root mean square deviation ; CUPSAT ; Cologne University Protein Stability Analysis Tool ; ΔΔG ; unfolding energy ; PDB ; Protein data bank ; MOE ; Molecular Operating Environment ; NPA ; Nosé ; -Poincaré ; -Anderson ; NVT ; N&ndash ; number of atoms ; V&ndash ; volume ; T&ndash ; temperature ; MD ; molecular dynamics ; ps ; picosecond ; SPDViewer ; Swiss PDB viewer

刊名：Gene

出版年：2016

7.Discovery and synthetic optimization of a novel scaffold for hydrophobic tunnel-targeted autotaxin inhibition

作者：Lauren E. Ragle^a ; Dilip J. Palanisamy^a ; Margaux J. Joe^a ; Rachel S. Stein^a ; Derek D. Norman^b ; Gabor Tigyi^b ; Daniel L. Baker^a ; Abby L. Parrill^a ;

关键词：ATX/NPP2 ; autotaxin ; DIPEA ; N ; N-diisopropylethylamine ; DMF ; N ; N-dimethylformamide ; DMSO ; dimethylsulfoxide ; GPCR ; G-protein coupled receptor ; GRI ; Genomic Research Institute ; HBTU ; O-(benzotriazol-1-yl)-NN ; N&prime ; N&prime ; -tetramethyluronium hexafluorophosphate ; LPC ; lysophosphatidylcholine ; LPA ; lysophosphatidic acid ; LysoPLD ; lysophospholipase-D ; MOE ; Molecular Operating Environment ; NPP ; nucleotide pyrophosphatase phosphodiesterase ; pNP-TMP ; p-nitrophenyl thymidine-5&prime ; -monophosphate ; p

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

8.TBECH, 1,2-dibromo-4-(1,2 dibromoethyl) cyclohexane, alters androgen receptor regulation in response to mutations associated with prostate cancer

作者：Joubert Banjop Kharlyngdoh ; Solomon Asnake ; Ajay Pradhan ; Per-Erik Olsson ; ^{per-erik.olsson@oru.se" class="auth_mail" title="E-mail the corresponding author}

关键词：AR ; androgen receptor ; BFR ; brominated flame retardant ; Ct ; cycle threshold ; DHT ; dihydrotestosterone ; EDC ; endocrine disrupting compound ; EF1A ; elongation factor 1 alpha ; HRP ; horseradish peroxidase ; ICM ; internal coordinates mechanics ; LBD ; ligand binding domain ; LBP ; ligand-binding pocket ; LCP1 ; L-plastin 1 ; MOE ; molecular operating environment ; MSMB ; microseminoprotein-βeta ; PCa ; Prostate cancer ; PDB ; protein data bank ; PSA ; prostate specific antigen ; qRT-PCR ; quantitative real time-polymera

刊名：Toxicology and Applied Pharmacology

出版年：2016

9.GPR40 agonists for the treatment of type 2 diabetes mellitus: The biological characteristics and the chemical space

作者：Cheng Chen^a ; ^b ; He Li^a ; Ya-Qiu Long^a ; ^{yqlong@simm.ac.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：GPR40 ; G protein-coupled receptor 40 ; FFA1 ; free fatty acid receptor 1 ; PK ; pharmacokinetic ; GSIS ; glucose-stimulated insulin secretion ; T2DM ; type 2 diabetes mellitus ; IDF ; International Diabetes Federation ; GLP-1 ; glucagon-like peptide1 ; GIP ; gastric inhibitory polypeptide ; DPP4 ; dipeptidyl peptidase-4 ; LA ; linoleic acid ; DHA ; docosahexaenoic acid ; IP3 ; inositol-triphosphate 3 ; DAG ; diacylglycerol ; PA ; palmitic acid ; OA ; oleic acid ; MOE ; molecular operating environment ; CNS ; central nervous sy

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

10.Synthesis and evaluation of analogs of the phenylpyridazinone NPD-001 as potent trypanosomal TbrPDEB1 phosphodiesterase inhibitors and in vitro trypanocidals

作者：Johan Veerman^a ; Toine van den Bergh^a ; Kristina M. Orrling^b ; Chimed Jansen^b ; Paul Cos^c ; Louis Maes^c ; Eric Chatelain^d ; Jean-Robert Ioset^d ; Ewald E. Edink^b ; Hermann Tenor^e ; Thomas Seebeck^f ; Iwan de Esch^b ; Rob Leurs^b ; Geert Jan Sterk^a ; ^b ; ^{g.j.sterk@vu.nl" class="auth_mail" title="E-mail the corresponding author}

关键词：MOE ; Molecular Operating Environment ; MW ; microwave ; TbrPDEB1 ; Trypanosoma brucei phosphodiesterase B1 ; TbrPDEB2 ; Trypanosoma brucei phosphodiesterase B2

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

按检索点细分(210)

题名(1)

关键词(25)

文摘(139)

按出版年细分(210)

2027年及以后(10)

2017年(3)

2016年(12)

2015年(3)

2013年(25)

2012年(12)

2011年(16)

2010年(22)

2009年(12)

2008年(14)

2007年(11)

2006年(12)

2005年(6)

2004年(7)

2003年(3)

2002年(5)

2001年(4)

2000年(5)

2000年及以前(28)

常见问题　|　交通位置　|　联系我们　|　OA远程办公

地址：北京市海淀区学院路29号邮编：100083

电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700