搜索页_+NNRTIs

设为首页

收藏本站

网站地图 | English | 公务邮箱

读者指南

学术客户端

NSTL服务站

科技查新

外文资源

Elsevier电子期刊(327)

在“Elsevier电子期刊”中，命中：327条，耗时：0.0119947 秒

在所有数据库中总计命中：327条

1.Discovery of novel piperidine-substituted indolylarylsulfones as potent HIV NNRTIs via structure-guided scaffold morphing and fragment rearrangement

作者：Xiao Li^a ; Ping Gao^a ; Boshi Huang^a ; Zhongxia Zhou^a ; Zhao Yu^a ; Zheng Yuan^c ; Huiqing Liu^c ; Christophe Pannecouque^b ; Dirk Daelemans^b ; Erik De Clercq^b ; Peng Zhan^a ; ^{zhanpeng1982@sdu.edu.cn} ; Xinyong Liu^a ; ^{xinyongl@sdu.edu.cn}

关键词：HIV ; NNRTIs ; Indolylarylsulfones ; Antiviral activity ; SAR ; Molecular modeling ; Chemical space ; Drug design

刊名：European Journal of Medicinal Chemistry

出版年：2017

2.Identifications of drug resistance mutations among antiretroviral treatment naive HIV-1 patients in Peninsular Malaysia

作者：Rozainanee Mohd Zain ; ^{rozainanee@yahoo.com} ; Nabila Ibrahim ; Suriani Ismail ; Jeyanthi Suppiah ; Nor Aziyah Mat Rahim ; Ravindran Thayan

关键词：HIV ; Resistance ; Malaysia ; Antiretroviral treatment naive

刊名：Asian Pacific Journal of Tropical Medicine

出版年：2017

3.Arylazolyl(azinyl)thioacetanilides. Part 20: Discovery of novel purinylthioacetanilides derivatives as potent HIV-1 NNRTIs via a structure-based bioisosterism approach

作者：Xueyi Lu^a ; Xiao Li^a ; Jiapei Yang^a ; Boshi Huang^a ; Dongwei Kang^a ; Fabao Zhao^a ; Zhongxia Zhou^a ; Erik De Clercq^b ; Dirk Daelemans^b ; Christophe Pannecouque^b ; ^{Christophe.Pannecouque@rega.kuleuven.be" class="auth_mail" title="E-mail the corresponding author} ; Peng Zhan^a ; ^{zhanpeng1982@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Xinyong Liu^a ; ^{xinyongl@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：HIV-1 ; AIDS ; NNRTIs ; Purinylthioacetanilide ; Anti-HIV activity ; Drug design ; Bioisosterism

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

4.Design, synthesis and evaluation of novel HIV-1 NNRTIs with dual structural conformations targeting the entrance channel of the NNRTI binding pocket

作者：Qing Meng^a ; Xuwang Chen^a ; Dongwei Kang^a ; Boshi Huang^a ; Wenxin Li^a ; Peng Zhan^a ; Dirk Daelemans^b ; Erik De Clercq^b ; Christophe Pannecouque^b ; ^{Christophe.Pannecouque@rega.kuleuven.be" class="auth_mail" title="E-mail the corresponding author} ; Xinyong Liu^a ; ^{xinyongl@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：HIV-1 NNRTIs ; DAPY derivatives ; Dual structural conformations ; Entrance channel ; SARs

刊名：European Journal of Medicinal Chemistry

出版年：2016

5.Novel indole sulfides as potent HIV-1 NNRTIs

作者：Siobhan Brigg^a ; Nicole Pribut^a ; Adriaan E. Basson^b ; Moscos Avgenikos^a ; Reinhardt Venter^a ; Margaret A. Blackie^a ; Willem A.L. van Otterlo^a ; Stephen C. Pelly^a ; ^{scpelly@sun.ac.za" class="auth_mail" title="E-mail the corresponding author}

关键词：HIV ; NNRTI ; Indole ; Sulfides

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

6.Computer-aided discovery of anti-HIV agents

作者：William L. Jorgensen ; ^{william.jorgensen@yale.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Structure-based design ; Free energy perturbation ; Anti-HIV drugs ; NNRTIs

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

7.1,6-Bis[(benzyloxy)methyl]uracil derivatives—Novel antivirals with activity against HIV-1 and influenza H1N1 virus

作者：Alexander N. Geisman^a ; Vladimir T. Valuev-Elliston^b ; Alexander A. Ozerov^a ; Anastasia L. Khandazhinskaya^b ; Alexander O. Chizhov^c ; Sergey N. Kochetkov^b ; Christophe Pannecouque^d ; Lieve Naesens^d ; Katherine L. Seley-Radtke^e ; ^{kseley@umbc.edu" class="auth_mail" title="E-mail the corresponding author} ; Mikhail S. Novikov^a

关键词：Uracil ; Non-nucleoside reverse transcriptase inhibitors ; NNRTIs ; HIV ; Influenza virus

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

8.Systematic evaluation of methyl ester bioisosteres in the context of developing alkenyldiarylmethanes (ADAMs) as non-nucleoside reverse transcriptase inhibitors (NNRTIs) for anti-HIV-1 chemotherapy

作者：Ayako Hoshi^a ; Takeshi Sakamoto^a ; ^{sakamoto@josai.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Jun Takayama^a ; Meiyan Xuan^a ; Mari Okazaki^a ; Tracy L. Hartman^b ; Robert W. Buckheit Jr.^b ; Christophe Pannecouque^c ; Mark Cushman^d ; ^{cushman@purdue.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：ADAM ; alkenyldiarylmethane ; NNRTI ; non-nucleoside reverse transcriptase inhibitor ; RT ; reverse transcriptase ; HIV-1 ; human immunodeficiency virus type 1 ; AIDS ; acquired immune deficiency syndrome ; ART ; antiretroviral therapy ; NRTI ; nucleoside reverse transcriptase inhibitor ; PI ; protease inhibitor ; INI ; integrase inhibitors ; FI ; fusion inhibitor ; CCR5I ; CC chemokine receptor inhibitor ; dNTPs ; deoxynucleoside triphosphate ; AZT ; azidothymidine (zidovudine) ; EDCI ; 1-(3-dimethylaminopropyl)-3-ethylc

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

9.Pharmacogenetics of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in resource-limited settings: Influence on antiretroviral therapy response and concomitant anti-tubercular, antimalarial and contraceptive treatments

作者：Gianluca Russo^a ; Giacomo Maria Paganotti^b ; ^c ; ^{paganottig@botswana-upenn.co.bw" class="auth_mail" title="E-mail the corresponding author} ; Sandra Soeria-Atmadja^d ; Miriam Haverkamp^b ; Doreen Ramogola-Masire^b ; Vincenzo Vullo^a ; Lars Lennart Gustafsson^e

关键词：Drug&ndash ; drug interactions ; Efavirenz ; HIV ; Nevirapine ; Pharmacogenetics ; Resource-limited countries

刊名：Infection, Genetics and Evolution

出版年：2016

10.Efavirenz a nonnucleoside reverse transcriptase inhibitor of first-generation: Approaches based on its medicinal chemistry

作者：Mô ; nica M. Bastos^a ; Carolina C.P. Costa^a ; ^b ; Talitha C. Bezerra^a ; ^c ; Fernando de C. da Silva^b ; Nú ; bia Boechat^a ; ^{boechat@far.fiocruz.br" class="auth_mail" title="E-mail the corresponding author}

关键词：AIDS ; Efavirenz ; Reverse transcriptase ; Structure&ndash ; activity relationship ; Synthesis ; HIV ; NNRTIs

刊名：European Journal of Medicinal Chemistry

出版年：2016

按检索点细分(327)

题名(43)

关键词(115)

文摘(249)

按出版年细分(327)

2027年及以后(9)

2017年(2)

2016年(12)

2015年(4)

2013年(14)

2012年(19)

2011年(25)

2010年(28)

2009年(36)

2008年(25)

2007年(22)

2006年(12)

2005年(15)

2004年(21)

2003年(4)

2002年(10)

2001年(18)

2000年(7)

2000年及以前(44)

常见问题　|　交通位置　|　联系我们　|　OA远程办公

地址：北京市海淀区学院路29号邮编：100083

电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700