搜索页_ Structure and activity relationship (SAR)

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Wiley电子期刊(30)	SpringerLink电子期刊(225)	NATURE电子期刊(4)	ACS电子期刊(477)
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在“Elsevier电子期刊”中，命中：2,286条，耗时：0.2968684 秒

在所有数据库中总计命中：3,026条

1.Structure-activity relationships of diverse xanthones against multidrug resistant human tumor cells

作者：Qiwen Wang^a ; Chenyao Ma^a ; Yun Ma^a ; Xiang Li^a ; ^c ; ^{lixiang_8182@163.com} ; Yong Chen^a ; ^{achenyongmail@163.com} ; Jianwei Chen^a ; ^b

关键词：Xanthone ; Cytotoxic activity ; Multidrug resistant ; Structure-activity relationships

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

2.A matrix-focused structure-activity and binding site flexibility study of quinolinol inhibitors of botulinum neurotoxin serotype A

作者：William A. Harrell Jr.^a ; ^d ; Rebecca C. Vieira^a ; ^e ; Susan M. Ensel^b ; Vicki Montgomery^a ; Rebecca Guernieri^a ; Vanessa S. Eccard^a ; ^f ; Yvette Campbell^a ; Virginia Roxas-Duncan^a ; ^g ; John H. Cardellina II^a ; ^h ; Robert P. Webb^a ; ^{robert.p.webb6.civ@mail.mil} ; Leonard A. Smith^c

关键词：BoNTs ; botulinum neurotoxins ; BoNT/A ; botulinum neurotoxin serotype A ; HC ; heavy chain ; LC ; light chain ; SNARE ; soluble N-ethylmaleimide-sensitive factor attachment protein receptor ; SNAP-25 ; 25 ; kDa synaptosomal-associated protein ; BIG-IV ; Botulism Immune Globulin Intravenous (Human) ; SAR ; structure-activity relationship ; IC50 ; 50% inhibitory concentration ; MPNHDA ; mouse phrenic nerve hemidiaphragm assay

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

3.The anti-proliferative activity of novel 4H-benzo[h]chromenes, 7H-benzo[h]-chromeno[2,3-d]pyrimidines and the structure-activity relationships of the 2-, 3-positions and fused rings at the 2, 3-positions

作者：Ahmed M. El-Agrody^a ; ^b ; ^{elagrody_am@yahoo.com} ; Ahmed H. Halawa^a ; Ahmed M. Fouda^b ; Al-Anood M. Al-Dies^b

关键词：4H-Benzo[h]chromenes ; 7H-Benzo[h]chromeno[2 ; 3-d]pyrimidines ; Antitumor ; SAR

刊名：Journal of Saudi Chemical Society

出版年：2017

4.Synthesis and structure-activity studies of side chain analogues of the anti-tubercular agent, Q203

作者：Sunhee Kang^a ; ^d ; Young Mi Kim^a ; Ryang Yeo Kim^b ; Min Jung Seo^a ; Zaesung No^a ; Kiyean Nam^c ; Sanghee Kim^d ; ^{pennkim@snu.ac.kr} ; Jaeseung Kim^a ; ^{silanediol@gmail.com}

关键词：Tuberculosis ; Imidazo[1 ; 2-a]pyridine-3-carboxamide (IPA) ; Pharmacokinetics ; Structure-activity relationship (SAR) ; Q203

刊名：European Journal of Medicinal Chemistry

出版年：2017

5.Synthesis and antitumor activity of some new pyrazolo[1,5-a]pyrimidines

作者：Ashraf S. Hassan^a ; ^{ashraf_salmoon@yahoo.com} ; Mohamed F. Mady^b ; ^c ; Hanem M. Awad^d ; Taghrid S. Hafez^a

关键词：5-Amino-1H-pyrazole ; Pyrazolo[1 ; 5-a]pyrimidine ; Schiff bases ; MTT assay ; Anticancer activity ; Structure activity relationship

刊名：Chinese Chemical Letters

出版年：2017

6.Structure-activity relationship-based screening of antibiotics against Gram-negative Acinetobacter baumannii

作者：Jee-Young Lee^a ; ^c ; Min-Cheol Jeong^b ; ^c ; Dasom Jeon^b ; Yeongjun Lee^b ; Woo Cheol Lee^b ; Yangmee Kim^b ; ^{ymkim@konkuk.ac.kr}

关键词：KAS ; Fatty acid synthesis ; Antibiotics ; In silico screening ; Gram-negative bacteria

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

7.Structure-activity relationships on the study of β-galactosidase folding/unfolding due to interactions with immobilization additives: Triton X-100 and ethanol

作者：Dayana Soto^a ; Sindy Escobar^a ; Fanny Guzmá ; n^b ; Constanza Cá ; rdenas^b ; Claudia Bernal^c ; Monica Mesa^a ; ^{monica.mesa@udea.edu.com} ; ^{mesacad@gmail.com}

关键词：BgaC ; β&ndash ; galactosidase from Bacillus circulans ; CD ; Circular Dichroism ; DSC ; Differential Scanning Calorimetry ; FTIR ; Infrared spectroscopy

刊名：International Journal of Biological Macromolecules

出版年：2017

8.Structure-activity relationship study and discovery of indazole 3-carboxamides as calcium-release activated calcium channel blockers

作者：Sha Bai^a ; Masazumi Nagai^a ; Steffi K. Koerner^a ; Aristidis Veves^b ; Lijun Sun^a ; ^{lsun1@bidmc.harvard.edu}

关键词：Mast cell ; Inflammation ; Calcium channel blockers ; Indazole-3-carboxamides

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

9.Design, synthesis and pharmacological evaluation of 4-hydroxyphenylglycine and 4-hydroxyphenylglycinol derivatives as GPR88 agonists

作者：Chunyang Jin ; ^cjin@rti.org ; Ann M. Decker ; Tiffany L. Langston

关键词：2-PCCA ; (1R ; 2R)-2-(pyridin-2-yl)cyclopropane carboxylic acid ((2S ; 3S)-2-amino-3-methylpentyl)-(4&prime ; -propylbiphenyl-4-yl)amide ; 2-AMPP ; (2S)-N-((1R)-2-amino-1-(4-(2-methyl-pentyloxy)phenyl)ethyl)-2-phenylpropanamide ; SAR ; structure activity relationship ; PPLS ; pre-prolactin leader sequence ; HA ; human influenza hemagglutinin ; HTRF ; homogeneous time resolved fluorescence ; MS ; mass spectroscopy ; TLC ; thin layer chromatography ; DIPEA ; N ; N-diisopropylethylamine ; DCM ; dichloromethane ; DEAD ; diethyl

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

10.Synthesis, anti-proliferative activity, SAR study, and preliminary in vivo toxicity study of substituted N,N′-bis(arylmethyl)benzimidazolium salts against a panel of non-small cell lung cancer cell lines

作者：Kerri L. Shelton^a ; Michael A. DeBord^a ; Patrick O. Wagers ; Marie R. Southerland ; Travis M. Williams ; Nikki K. Robishaw ; Leah P. Shriver ; Claire A. Tessier ; Matthew J. Panzner ; Wiley J. Youngs ; ^{youngs@uakron.edu}

关键词：NCI ; National Cancer Institute ; IC50 ; inhibitory concentration 50% ; NSCLC ; non-small cell lung cancer ; MTT ; 3-(4 ; 5-dimethylthiazol-2-yl)-2 ; 5-diphenyltetrazolium bromide ; SAR ; structure-activity relationship ; GI50 ; growth inhibition 50% ; TGI ; total growth inhibition ; LC50 ; lethal concentration 50% ; DTP ; Developmental Therapeutics Program ; 2-HPβCD ; 2-hydropropyl-β-cyclodextrin

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

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