作者：Jiseon Kim^a ; Jee Sun Min^a ; Doyun Kim^a ; Yu Fen Zheng^a ; Karabasappa Mailar^b ; Won Jun Choi^b ; Choongho Lee^b ; Soo Kyung Bae^a ; ^{baesk@catholic.ac.kr} ; ^{espero97@hanmail.net}

关键词：AUC0-t ; total area under the plasma concentration&minus ; time curve from time zero to time t ; AUC0-&infin ; total area under the plasma concentration&minus ; time curve from time zero to time infinity ; F ; bioavailability ; Cl ; total plasma clearance ; Cmax ; peak plasma concentration ; IS ; internal standard ; LC&ndash ; MS/MS ; liquid chromatography&ndash ; tandem mass spectrometry ; LLOQ ; lower limit of quantitation ; QC ; quality control ; RE ; relative error ; RSD ; relative standard deviation ; Vd ; steady-state

刊名：Journal of Pharmaceutical and Biomedical Analysis

出版年：2017

作者：Aishwarya Balap^a ; Sathiyanarayanan Lohidasan^a ; Arulmozhi Sinnathambi^b ; Kakasaheb Mahadik^a ; ^{krmahadik@redifffmail.com}

关键词：AN ; Andrographolide ; ANOVA ; Analysis of variance ; APE ; Andrographis paniculata Nees Extract ; AUC 0-&infin ; Area under plasma concentration-time curve extrapolated to infinity ; AUC0&minust ; Area under plasma concentration-time curve from zero to last time point ; AUMC0-&infin ; Area under the concentration time (c&times ; t) versus time (t) curve for extrapolated to infinity ; AUMC0&minust ; Area under the concentration time (c&times ; t) versus time (t) curve for last time point ; CL ; Plasma clearanc

刊名：Journal of Ethnopharmacology

出版年：2017

作者：Kareem AbuBakr Soliman ; ^{karim.mohamed@pharma.cu.edu.eg} ; Howida Kamal Ibrahim ; Mahmoud Mohammed Ghorab

关键词：ANOVA ; analysis of variance ; AUC(0&minus ; &infin) ; area under plasma concentration-time curve extrapolated to infinity ; Cmax ; peak plasma concentration ; D.E.(0&ndash ; 30) ; dissolution efficiency (0&ndash ; 30&thinsp ; min) ; DMSO ; dimethyl sulphoxide ; DSC ; differential scanning calorimetry ; FDA ; United States Food and Drug Administration ; HPH ; high pressure homogenization ; HLB ; hydrophilic-lipophilic balance ; HPLC ; high-performance liquid chromatography ; PDE5 ; phosphodiesterase enzyme type 5 ; PDI ; pol

刊名：International Journal of Pharmaceutics

出版年：2017

作者：Joanna Giebułtowicz^a ; ^{joanna.giebultowicz@wum.edu.pl" class="auth_mail" title="E-mail the corresponding author} ; Roman Piotrowski^b ; Jakub Baran^b ; Piotr Kułakowski^b ; Piotr Wroczyński^a

关键词：AF ; atrial fibrillation ; AN-PAF ; Clinical efficacy of ANtazoline in rapid cardioversion of Paroxysmal Atrial Fibrillation ; a single center ; randomized ; double blind ; placebo-controlled study ; AUCt ; area under the plasma concentration-time curve from time zero to time t ; AUC&infin ; area under the plasma concentration-time curve from time zero to infinity ; C0 ; back-extrapolated plasma drug concentration at time zero following bolus intravenous injection ; Cl ; apparent total body clearance of the d

刊名：Journal of Pharmaceutical and Biomedical Analysis

出版年：2016

作者：Frank LaCreta^a ; ^{frank.lacreta@bms.com" class="auth_mail" title="E-mail the corresponding author} ; Steven C. Griffen^a ; ¹ ; ^{sgriffen@jdrf.org" class="auth_mail" title="E-mail the corresponding author} ; Xiaoni Liu^a ; ^{xiaoni.liu@bms.com" class="auth_mail" title="E-mail the corresponding author} ; Charles Smith^b ; ^{charles.smith@ppdi.com" class="auth_mail" title="E-mail the corresponding author} ; Carey Hines^b ; ^{carey.hines@ppdi.com" class="auth_mail" title="E-mail the corresponding author} ; Kevin Volk^c ; ^{kevin.volk@bms.com" class="auth_mail" title="E-mail the corresponding author} ; Ravindra Tejwani^c ; ² ; ^{tejwanir@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; David W. Boulton^d ; ^{david.boulton2@astrazeneca.com" class="auth_mail" title="E-mail the corresponding author}

关键词：AUC0⿿t ; area under the plasma concentration⿿time curve from time 0 to the last quantifiable concentration ; AUC0⿿inf ; area under the plasma concentration⿿time curve from time 0 to infinity ; Cp ; plasma concentration ; Cmax ; maximum Cp ; Dapagliflozin ; [2S ; 3R ; 4R ; 5S ; 6R]-2-[4-chloro-3-(4-ethoxybenzyl)phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-34 ; 5-triol ; compounded with (2S)-1 ; 2-propanediol ; hydrate (11 ; 1) ; HS ; heat-stressed ; Kel ; terminal rate constant ; LS ; least squares ; NH ; non⿿heat-stressed ; tm

刊名：International Journal of Pharmaceutics

出版年：2016

作者：Aishwarya Balap^a ; Bhagyashri Atre^b ; Sathiyanarayanan Lohidasan^a ; ^{pharmsathiya@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Arulmozhi Sinnathambi^b ; Kakasaheb Mahadik^a ; ^{krmahadik@redifffmail.com" class="auth_mail" title="E-mail the corresponding author}

关键词：AN ; Andrographolide ; ANOVA ; Analysis of variance ; APE ; Andrographis Paniculata Nees Extract ; AUC0&ndash ; &infin ; Area under plasma concentration&ndash ; time curve extrapolated to infinity ; AUClast ; Area under plasma concentration&ndash ; time curve from zero to last time point ; AUMC0&ndash ; &infin ; Area under the concentration time (c&times ; t) versus time (t) curve for extrapolated to infinity ; AUMClast ; Area under the concentration time (c&times ; t) versus time (t) curve for last time point ; CL ; Pl

刊名：Journal of Ethnopharmacology

出版年：2016

作者：Ola Sternebring ; Jesper Kammersgaard Christensen ; Inga Bjø ; rnsdottir ; ^{Inbj@novonordisk.com" class="auth_mail" title="E-mail the corresponding author}

关键词：ADME ; absorption ; distribution ; metabolism ; and excretion ; AMS ; accelerator mass spectrometry ; AUC ; area under the plasma concentration&ndash ; time curve from zero to infinity ; AUC[0&ndash ; t] ; area under the plasma concentration&ndash ; time curves from zero to time t ; AUCextrap ; extrapolated area under the plasma concentration&ndash ; time curves from the last sampling time point to infinity ; CL ; total plasma clearance ; CLd ; intercompartmental distribution clearance ; C0 ; concentration at time zero

刊名：European Journal of Pharmaceutical Sciences

出版年：2016

作者：Leonie H.E. Leithold^a ; ¹ ; ^{l.hofmann@fz-juelich.de" class="auth_mail" title="E-mail the corresponding author} ; Nan Jiang^a ; ¹ ; ^{n.jiang@fz-juelich.de" class="auth_mail" title="E-mail the corresponding author} ; Julia Post^a ; ^{j.post@fz-juelich.de" class="auth_mail" title="E-mail the corresponding author} ; Nicole Niemietz^b ; ^{n.niemietz@fz-juelich.de" class="auth_mail" title="E-mail the corresponding author} ; Elena Schartmann^a ; ^{e.schartmann@fz-juelich.de" class="auth_mail" title="E-mail the corresponding author} ; Tamar Ziehm^a ; ^{t.ziehm@fz-juelich.de" class="auth_mail" title="E-mail the corresponding author} ; Janine Kutzsche^a ; ^{j.kutzsche@fz-juelich.de" class="auth_mail" title="E-mail the corresponding author} ; N. Jon Shah^b ; ^c ; ^{n.j.shah@fz-juelich.de" class="auth_mail" title="E-mail the corresponding author} ; Jö ; rg Breitkreutz^d ; ^{joerg.breitkreutz@uni-duesseldorf.de" class="auth_mail" title="E-mail the corresponding author} ; Karl-Josef Langen^b ; ^e ; ^{k.j.langen@fz-juelich.de" class="auth_mail" title="E-mail the corresponding author} ; Antje Willuweit^b ; ^{a.willuweit@fz-juelich.de" class="auth_mail" title="E-mail the corresponding author} ; Dieter Willbold^a ; ^f ; ^{d.willbold@fz-juelich.de" class="auth_mail" title="E-mail the corresponding author}

关键词：%ID ; relative injected dose ; AD ; Alzheimer's disease ; AGP ; α1-acid glycoprotein ; AUC ; area under the concentration-time curve ; AUMC ; area under the moment curve ; Aβ ; β-amyloid ; C ; concentration ; Cl ; clearance ; D ; dose ; dpm ; disintegrations per minute ; F ; bioavailability ; fu ; unbound fraction ; HSA ; human serum albumin ; i.p. ; intraperitoneal ; i.v. ; intravenous ; inf ; infinity ; KD ; dissociation constant ; MRT ; mean residence time ; r2 ; correlation coefficient ; t1/2 ; terminal half-life ; TLC ; thin layer

刊名：European Journal of Pharmaceutical Sciences

出版年：2016

作者：Naama Levy-Cooperman^a ; ¹ ; ^{nlevy-cooperman@altreos.com" class="auth_mail" title="E-mail the corresponding author} ; Kerri A. Schoedel^a ; ¹ ; ^{kschoedel@altreos.com" class="auth_mail" title="E-mail the corresponding author} ; Bijan Chakraborty^a ; ² ; ^{bijan.chakraborty@rogers.com" class="auth_mail" title="E-mail the corresponding author} ; David Blum^b ; ^{david.blum@sunovion.com" class="auth_mail" title="E-mail the corresponding author} ; Hailong Cheng^b ; ^{hailong.cheng@sunovion.com" class="auth_mail" title="E-mail the corresponding author}

关键词：λz ; elimination rate constant ; AED ; antiepileptic drug ; AE ; adverse event ; ANCOVA ; analysis of covariance ; ARCI ; Addiction Research Center Inventory ; ALP ; alprazolam ; AST ; aspartate aminotransferase ; AUC ; area under the curve ; AUC0&ndash ; last ; AUC from time zero to the last measurable concentration ; AUC0&ndash ; &infin ;   ; AUC from time zero to infinity ; BMI ; body mass index ; CI ; confidence interval ; CL/F ; apparent total clearance ; Cmax ; maximum observed plasma concentration ; CNS ; central nerv

刊名：Epilepsy & Behavior

出版年：2016

作者：Jennifer A. Dumont ; ^{jennifer.dumont@biogen.com" class="auth_mail" title="E-mail the corresponding author} ; Kenneth S. Loveday ^{kenneth.loveday@biogen.com" class="auth_mail" title="E-mail the corresponding author} ; David R. Light ^{david.light@biogen.com" class="auth_mail" title="E-mail the corresponding author} ; Glenn F. Pierce ^{glennfpierce@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Haiyan Jiang ^{haiyan.jiang@biogen.com" class="auth_mail" title="E-mail the corresponding author}

关键词：aPTT ; activated partial thromboplastin time ; AUC&infin ; area under the curve from zero to time infinity ; AUClast ; area under the curve up to the last measurable concentration ; BW ; body weight ; CL ; clearance ; Cmax ; maximum plasma concentration ; ECG ; electrocardiogram ; ELISA ; enzyme-linked immunosorbent assay ; F ; female ; FcRn ; neonatal Fc receptor ; FVIII ; factor VIII ; GLP ; Good Laboratory Practice ; HEK ; human embryonic kidney ; HR ; heart rate ; IgG1 ; immunoglobulin G1 ; M ; male ; MRT ; mean residence

刊名：Thrombosis Research

出版年：2015