作者：Maiara Cá ; ssia Pigatto^a ; ^b ; ^c ; Renatha Menti Roman^c ; Letizia Carrara^d ; André ; ia Buffon^a ; ^c ; Paolo Magni^d ; Teresa Dalla Costa^a ; ^c ; ^{dalla.costa@ufrgs.br}

关键词：W256 ; Walker-256 ; HPLC-UV ; high pressure liquid chromatography-ultraviolet ; PK/PD ; pharmacokinetic/pharmacodynamic ; popPK ; population pharmacokinetic ; TGI ; Tumor Growth Inhibition ; NAD ; Naï ; ve Average Data ; SAEM ; stochastic approximation expectation maximization ; GOF ; goodness-of-fit ; VPC ; visual predictive check ; AUC ; area under the curve

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

作者：Thomas Danne ; MD¹ ; ^danne@hka.de ; Torben Biester ; MD¹ ; Kerstin Kapitzke ; MD¹ ; Sanja H. Jacobsen ; MSc² ; Lisbeth V. Jacobsen ; MSc² ; Kristin C. Carlsson Petri ; PhD² ; Paula M. Hale ; MD³ ; Olga Kordonouri ; MD¹

关键词：GLP-1 receptor agonist ; pharmacodynamics ; phase I

刊名：The Journal of Pediatrics

出版年：2017

作者：Nanthanit Pholphana^a ; ¹ ; Duangchit Panomvana^b ; ¹ ; Nuchanart Rangkadilok^a ; ^c ; Tawit Suriyo^a ; Porranee Puranajoti^b ; Teerapat Ungtrakul^d ; Wanwisa Pongpun^d ; Saichit Thaeopattha^b ; Phanit Songvut^b ; Jutamaad Satayavivad^a ; ^c ; ^e ; ^{jutamaad@cri.or.th}

关键词：1 ; andrographolide ; 2 ; 14-deoxy-11 ; 12-didehydroandrographolide ; 3 ; neoandrographolide ; 4 ; 14-deoxyandrographolide ; AUC ; area under plasma concentration-time curve ; Cmax ; maximum concentration ; Cl ; clearance ; EDTA ; ethylenediaminetetraacetic acid ; F ; bioavailability ; IS ; internal standard ; Ke ; elimination rate constant ; LLOQ ; lower limit of quantification ; MRT ; mean resident time ; t1/2 ; elimination half-life ; Tmax ; time at the maximum concentration ; Vd ; volume of distribution

刊名：Journal of Ethnopharmacology

出版年：2016

作者：Volha Zabela^a ; ^{volha.zabela@unibas.ch} ; Chethan Sampath^b ; ^{chethan@ufl.edu} ; Mouhssin Oufir^a ; ^{mouhssin.oufir@unibas.ch} ; Fahimeh Moradi-Afrapoli^a ; Veronika Butterweck^b ; ¹ ; ^{veronika.butterweck@fhnw.ch} ; Matthias Hamburger^a ; ^{matthias.hamburger@unibas.ch}

关键词：AA ; acetic acid ; AIC ; Akaike's information criterion ; AUC ; area under the curve ; AUMC ; area under the first moment curve ; BBB ; blood-brain barrier ; b.w. ; body weight ; C0 ; concentration at time 0 ; CA ; compartmental analysis ; Cals ; calibrators ; CL ; clearance ; Cmax ; maximal concentration ; CV ; coefficient of variation ; FA ; formic acid ; 4-HPAA ; 4-hydroxyphenylacetic acid ; i.p. ; intraperitoneally ; IS ; internal standard ; i.v. ; intravenously ; ke ; elimination rate constant ; LLOQ ; lower limit of quantific

刊名：Fitoterapia

出版年：2016

作者：Christos C. Liolios^a ; ^b ; ^d ; ^{c.liolios@dkfz-heidelberg.de" class="auth_mail" title="E-mail the corresponding author} ; Stavros Xanthopoulos^a ; George Loudos^c ; Alexandra D. Varvarigou^a ; Gregory B. Sivolapenko^b

关键词：*A ; a ; Macro-constants from the compartmental PK approach ; C0 ; Concentration at t  ; = 0 ; AUC ; Area under the curve ; calculated from the (% Injected Dose/g)-time plot ; AUMC ; Area under the first statistical moment curve ; BW ; Body weight ; CL ; Clearance of the drug ; DIC ; N ; N-diisopropylcarbodiimide ; ID ; Injected dose ; MRT ; Mean residence time ; t1/2a ; Time of half-life for the drug concentration in the blood ; Vd ; Volume of distribution ; Vss ; Volume of distribution at steady state ; DMF ; Dimet

刊名：Nuclear Medicine and Biology

出版年：2016

作者：Daniel Scotcher^a ; Christopher Jones^b ; Amin Rostami-Hodjegan^a ; ^c ; Aleksandra Galetin^a ; ^{Aleksandra.Galetin@manchester.ac.uk" class="auth_mail" title="E-mail the corresponding author}

关键词：AUC ; area under the plasma concentration-time profile ; BCRP ; breast cancer resistance protein ; CD ; collecting duct ; Cp ; plasma concentration ; CLR ; renal excretion clearance ; CLR ; filt ; renal filtration clearance ; CLR ; int ; reab ; intrinsic permeability clearance in renal tubule ; CLR ; sec ; renal secretion clearance ; DT ; distal tubule ; fup ; fraction of drug unbound in plasma ; Freab ; fraction of the drug reabsorbed in the renal tubule ; Freab&rsquo ; intermediate model parameter ; representing the frac

刊名：European Journal of Pharmaceutical Sciences

出版年：2016

作者：Leonie H.E. Leithold^a ; ¹ ; ^{l.hofmann@fz-juelich.de" class="auth_mail" title="E-mail the corresponding author} ; Nan Jiang^a ; ¹ ; ^{n.jiang@fz-juelich.de" class="auth_mail" title="E-mail the corresponding author} ; Julia Post^a ; ^{j.post@fz-juelich.de" class="auth_mail" title="E-mail the corresponding author} ; Nicole Niemietz^b ; ^{n.niemietz@fz-juelich.de" class="auth_mail" title="E-mail the corresponding author} ; Elena Schartmann^a ; ^{e.schartmann@fz-juelich.de" class="auth_mail" title="E-mail the corresponding author} ; Tamar Ziehm^a ; ^{t.ziehm@fz-juelich.de" class="auth_mail" title="E-mail the corresponding author} ; Janine Kutzsche^a ; ^{j.kutzsche@fz-juelich.de" class="auth_mail" title="E-mail the corresponding author} ; N. Jon Shah^b ; ^c ; ^{n.j.shah@fz-juelich.de" class="auth_mail" title="E-mail the corresponding author} ; Jö ; rg Breitkreutz^d ; ^{joerg.breitkreutz@uni-duesseldorf.de" class="auth_mail" title="E-mail the corresponding author} ; Karl-Josef Langen^b ; ^e ; ^{k.j.langen@fz-juelich.de" class="auth_mail" title="E-mail the corresponding author} ; Antje Willuweit^b ; ^{a.willuweit@fz-juelich.de" class="auth_mail" title="E-mail the corresponding author} ; Dieter Willbold^a ; ^f ; ^{d.willbold@fz-juelich.de" class="auth_mail" title="E-mail the corresponding author}

关键词：%ID ; relative injected dose ; AD ; Alzheimer's disease ; AGP ; α1-acid glycoprotein ; AUC ; area under the concentration-time curve ; AUMC ; area under the moment curve ; Aβ ; β-amyloid ; C ; concentration ; Cl ; clearance ; D ; dose ; dpm ; disintegrations per minute ; F ; bioavailability ; fu ; unbound fraction ; HSA ; human serum albumin ; i.p. ; intraperitoneal ; i.v. ; intravenous ; inf ; infinity ; KD ; dissociation constant ; MRT ; mean residence time ; r2 ; correlation coefficient ; t1/2 ; terminal half-life ; TLC ; thin layer

刊名：European Journal of Pharmaceutical Sciences

出版年：2016

作者：Miriam Verwei^a ; ^b ; ^{miriam.verwei@tno.triskelion.nl" class="auth_mail" title="E-mail the corresponding author} ; Mans Minekus^a ; ^b ; Evelijn Zeijdner^a ; Ronald Schilderink^a ; ^b ; Robert Havenaar^b

关键词：API ; active pharmaceutical ingredient ; AUC ; area under (the plasma concentration) curve ; BAmax ; maximum bioaccessible amount of API per time period (e.g. per 30  ; min) ; BCS ; biopharmaceutics classification system ; GI ; gastrointestinal ; HFM ; high fat meal (as FDA recommended for in vivo pharma studies) ; IMI ; innovative medicines initiative ; IR ; immediate release formulation ; MR ; modified release formulation (e.g. extended release (ER) formulation) ; OrBiTo ; oral biopharmaceutical tools (IMI pro

刊名：International Journal of Pharmaceutics

出版年：2016

作者：Yuan-yuan Xie^a ; ^{yuanyuan_sy@mail.tsinghua.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Xiu-ming Wang^a ; Si-huan Wang^a ; Yi-ming Wang^a ; Hui-fang Tian^d ; Yong-sheng Yuan^c ; Hong-yan Li^c ; Qiong-lin Liang^a ; Guo-an Luo^a ; ^b ; ^{luoga@mail.tsinghua.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：Anemarrhenae rhizoma ; Xanthones C-glycosides ; Mangiferin ; Neomangiferin ; Plasma pharmacokinetics ; Metabolites ; Rat ; LC&ndash ; MS

刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences

出版年：2016

作者：Niels Erik Olesen^a ; ^b ; Peter Westh^b ; René ; Holm^a ; ^{rhol@lundbeck.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Cyclodextrins ; Risk analysis ; Pharmacokinetics ; Modelling ; Fraction absorbed ; Oral absorption ; Rats

刊名：European Journal of Pharmaceutics and Biopharmaceutics

出版年：2016