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Elsevier电子期刊(1188)

在“Elsevier电子期刊”中，命中：1,188条，耗时：0.0209609 秒

在所有数据库中总计命中：1,188条

1.Explicit treatment of active-site waters enhances quantum mechanical/implicit solvent scoring: Inhibition of CDK2 by new pyrazolo[1,5-a]pyrimidines

作者：Michaela Hylsová ; ^a ; ¹ ; Benoit Carbain^a ; ^f ; ¹ ; Jindřich Fanfrlí ; k^b ; ¹ ; Lenka Musilová ; ^a ; Susanta Haldar^b ; ^c ; Cemal Kö ; prü ; lü ; oğlu^b ; ^c ; Haresh Ajani^b ; ^c ; Pathik S. Brahmkshatriya^b ; Radek Jorda^d ; Vladimí ; r Kry&scaron ; tof^d ; Pavel Hobza^b ; ^c ; Aude Echalier^e ; ² ; Kamil Paruch^a ; ^f ; ^{paruch@chemi.muni.cz} ; Martin Lep&scaron ; í ; k^b ; ^{lepsik@uochb.cas.cz}

关键词：Cyclin-dependent kinase 2 ; ATP-competitive type I inhibitors ; Pyrazolo[1 ; 5-a]pyrimidine ; Quantum mechanical scoring ; Protein-ligand binding ; Molecular dynamics ; Water thermodynamics ; X-ray crystal structure

刊名：European Journal of Medicinal Chemistry

出版年：2017

2.G₂/M cell cycle arrest on HT-29 cancer cells and toxicity assessment of triphenylphosphanegold(I) carbonimidothioates, Ph₃PAu[SC(OR) = NPh], R = Me, Et, and iPr, during zebrafish development

作者：Kah Kooi Ooi^a ; ^b ; Chien Ing Yeo^b ; Theventhiran Mahandaran^c ; Kok Pian Ang^a ; Abdah Md Akim^a ; Yoke-Kqueen Cheah^a ; Hoi-Ling Seng^d ; ^{hoilings@sunway.edu.my} ; Edward R.T. Tiekink^b ; ^{edwardt@sunway.edu.my}

关键词：Annexin V-FITC ; Recombinant annexin V conjugated to fluorescein isothiocyanate ; APAF-1 ; Apoptotic protease activating factor 1 ; ATR ; Ataxia telangiectasia and Rad3-related ; Bax ; Apoptosis regulator ; Bcl-2 ; B-cell lymphoma 2 ; BIRC-5 ; Baculoviral inhibitor of apoptosis repeat-containing 5/ Survivin ; CCNB1 ; Cyclin B1 ; cdc25C ; Cell division cycle 25C ; CDKN1A ; Cyclin-dependent kinase N1A ; CDK2 ; Cyclin-dependent kinase 2 ; CDK4 ; Cyclin-dependent kinase 4 ; CHEK1/Chk1 ; Checkpoint kinase 1 ; CHEK2/Chk2 ; Ch

刊名：Journal of Inorganic Biochemistry

出版年：2017

3.NOX2-ROS-HIF-1α signaling is critical for the inhibitory effect of oleanolic acid on rectal cancer cell proliferation

作者：Yongfeng Guo^a ; Bing Han^b ; Kongliang Luo^a ; Zhijian Ren^a ; Lei Cai^c ; ^{lc121123@163.com} ; Li Sun^c ; ^{lisun31@163.com}

关键词：Rectal cancer ; Oleanolic acid ; Proliferation ; NOX2 ; HIF-1α

刊名：Biomedicine & Pharmacotherapy

出版年：2017

4.Vibrational spectroscopic investigations, molecular dynamic simulations and molecular docking studies of N′-diphenylmethylidene-5-methyl-1H-pyrazole-3-carbohydrazide

作者：Renjith Raveendran Pillai^a ; Vidya V. Menon^b ; ^c ; Y. Shyma Mary^d ; Stevan Armaković^e ; Sanja J. Armaković^f ; C. Yohannan Panicker^a ; ^d ; ^{cyphyp@rediffmail.com}

关键词：DFT ; Pyrazine ; Molecular dynamics ; FT-IR ; FT-Raman ; Docking

刊名：Journal of Molecular Structure

出版年：2017

5.siRNA-cell-penetrating peptides complexes as a combinatorial therapy against chronic myeloid leukemia using BV173 cell line as model

作者：Joã ; o Miguel Freire^a ; ¹ ; Inê ; s Rego de Figueiredo^a ; ¹ ; Javier Valle^b ; Ana Salomé ; Veiga^a ; David Andreu^b ; Francisco J. Enguita^a ; ^{fenguita@medicina.ulisboa.pt} ; Miguel A.R.B. Castanho^a ; ^{macastanho@medicina.ulisboa.pt}

关键词：Chronic myeloid leukemia ; Bcr-Abl ; siRNA ; Dengue virus capsid protein ; Cell-penetrating peptide ; Bioportide ; Microarray

刊名：Journal of Controlled Release

出版年：2017

6.Novel miR-5582-5p functions as a tumor suppressor by inducing apoptosis and cell cycle arrest in cancer cells through direct targeting of GAB1, SHC1, and CDK2

作者：Hyun-Ju An^a ; ^b ; Seo-Young Kwak^a ; ^b ; Je-Ok Yoo^a ; Jae-Sung Kim^a ; In-Hwa Bae^a ; Myung-Jin Park^a ; Mee-Yon Cho^c ; Joon Kim^b ; Young-Hoon Han^a ; ^{yhhan@kirams.re.kr" class="auth_mail" title="E-mail the corresponding author} ; ^{yhhan33@hanmail.net" class="auth_mail" title="E-mail the corresponding author}

关键词：CRC ; colorectal cancer ; miRNA ; microRNA ; MTS ; (3-(4 ; 5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) ; GAB1 ; GRB2-associated binding protein 1 ; SHC1 ; SRC homology 2 domain containing 1 ; GRB2 ; growth factor receptor-bound protein 2 ; CDK2 ; cyclin-dependent kinase 2 ; SDS ; sodium dodecyl sulfate ; PAGE ; polyacrylamide gel electrophoresis ; FBS ; fetal bovine serum ; TUNEL ; terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling ; qRT-PCR ; quantitative rea

刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

出版年：2016

7.Benzamide capped peptidomimetics as non-ATP competitive inhibitors of CDK2 using the REPLACE strategy

作者：Padmavathy Nandha Premnath^&dagger ; ; ^{pnpremnath@une.edu" class="auth_mail" title="E-mail the corresponding author} ; Sandra N. Craig ; Shu Liu^&Dagger ; ; ^{shu.liu@ucsfmedctr.org" class="auth_mail" title="E-mail the corresponding author} ; Campbell McInnes ; ^{mcinnes@sccp.sc.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Cyclin dependent kinase ; Protein&ndash ; protein interaction ; Cyclin groove ; REPLACE ; Inhibitor

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

8.Synthesis, biological evaluation and molecular modeling of a novel series of 7-azaindole based tri-heterocyclic compounds as potent CDK2/Cyclin E inhibitors

作者：Christine B. Baltus^a ; ¹ ; Radek Jorda^b ; ¹ ; ^{radek.jorda@upol.cz" class="auth_mail" title="E-mail the corresponding author} ; Christophe Marot^a ; Karel Berka^c ; ^d ; Vá ; clav Bazgier^b ; ^d ; Vladimí ; r Kry&scaron ; tof^b ; Gildas Prié ; ^a ; Marie-Claude Viaud-Massuard^a ; ^{marie-claude.viaud-massuard@univ-tours.fr" class="auth_mail" title="E-mail the corresponding author}

关键词：Cyclin-dependent kinase 2 ; Kinase inhibitors ; Anti-tumor agent ; 1H-pyrrolo[2 ; 3-b]pyridine ; [3 ; + ; 2] cycloaddition ; 1 ; 4-Triazole ; 1 ; 5-Triazole ; 3D-QSAR CoMFA

刊名：European Journal of Medicinal Chemistry

出版年：2016

9.Discovery of novel nonpeptide allosteric inhibitors interrupting the interaction of CDK2/cyclin A3 by virtual screening and bioassays

作者：Yutong Hu^a ; ^b ; ^&dagger ; ; Shuai Li^b ; ^&dagger ; ; Fang Liu^c ; ^&dagger ; ; Lv Geng^b ; Xiaohong Shu^a ; ^{xiaohong_shu@dlmedu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Jian Zhang^b ; ^{jian.zhang@sjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：Cell cycle ; Allosteric regulation ; CDK2 allosteric inhibitors ; Virtual screening

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2015

10.A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties

作者：Vikas Kumar^a ; ^b ; Santosh K. Guru^c ; Shreyans K. Jain^b ; ^d ; Prashant Joshi^b ; ^e ; Sumit G. Gandhi^b ; ^f ; Sandip B. Bharate^b ; ^e ; Shashi Bhushan^b ; ^c ; Sonali S. Bharate^a ; ^{sonalibharate@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Ram A. Vishwakarma^b ; ^e ; ^{ram@iiim.ac.in" class="auth_mail" title="E-mail the corresponding author}

关键词：Rohitukine ; Cdk2 ; Cdk9 ; Chromatography-free isolation ; Dysoxylum binectariferum ; Physicochemical properties

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

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