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Wiley电子期刊(9)	ProQuest学位论文(1)	ACS电子期刊(49)
SpringerLink电子期刊(117)	Elsevier电子期刊(234)

在“Elsevier电子期刊”中，命中：234条，耗时：0.0379822 秒

在所有数据库中总计命中：410条

1.Alamethicin for using in bioavailability studies? - Re-evaluation of its effect

作者：Maren Vollmer ^{Maren.Vollmer@chemie.uni-hamburg.de} ; Mirko Klingebiel ^{mikl1710@kdwelt.de} ; Sascha Rohn ; ^{rohn@chemie.uni-hamburg.de} ; Ronald Maul ^{maul@chemie.uni-hamburg.de}

关键词：Clint ; intrinsic clearance ; Clint app. ; apparent intrinsic clearance ; DAD ; diod array detector ; DMSO ; dimethyl sulfoxide ; ER ; endoplasmic reticulum ; fu ; unbound fraction of a drug in the microsomal incubation mixture ; HPLC ; high performance liquid chromatography ; Km ; Michaelis-Menten constant ; P ; partition coefficient ; S ; substrate concentration ; UDP ; uridine diphosphate ; UDPGA ; uridine 5&prime ; -diphosphoglucuronic acid trisodium salt ; UGT ; UDP-glucuronosyltransferase ; v ; velocity ; Vmax ; maximal

刊名：Toxicology in Vitro

出版年：2017

2.New IVIVE method for the prediction of total human clearance and relative elimination pathway contributions from in vitro hepatocyte and microsome data

作者：Julia Riede^a ; ^b ; Birk Poller^a ; Ken-ichi Umehara^a ; Jö ; rg Huwyler^b ; Gian Camenisch^a ; ^{gian.camenisch@novartis.com" class="auth_mail" title="E-mail the corresponding author}

关键词：AFE ; average fold error ; CLh ; hepatic clearance ; CLint ; intrinsic clearance ; CLinth ; intrinsic hepatic clearance ; CLint ; met ; intrinsic metabolic clearance ; CLint ; sec ; intrinsic secretory clearance ; CLren ; renal clearance ; CLtot ; total clearance ; CYP ; cytochrome P450 ; ECCCS ; Extended Clearance Concept Classification System ; ECM ; Extended Clearance Model ; fnh ; fraction of hepatic elimination ; fnmet ; fraction of metabolic elimination ; fnren ; fraction of renal elimination ; fnsec ; fraction of biliar

刊名：European Journal of Pharmaceutical Sciences

出版年：2016

3.Novel minimal physiologically-based model for the prediction of passive tubular reabsorption and renal excretion clearance

作者：Daniel Scotcher^a ; Christopher Jones^b ; Amin Rostami-Hodjegan^a ; ^c ; Aleksandra Galetin^a ; ^{Aleksandra.Galetin@manchester.ac.uk" class="auth_mail" title="E-mail the corresponding author}

关键词：AUC ; area under the plasma concentration-time profile ; BCRP ; breast cancer resistance protein ; CD ; collecting duct ; Cp ; plasma concentration ; CLR ; renal excretion clearance ; CLR ; filt ; renal filtration clearance ; CLR ; int ; reab ; intrinsic permeability clearance in renal tubule ; CLR ; sec ; renal secretion clearance ; DT ; distal tubule ; fup ; fraction of drug unbound in plasma ; Freab ; fraction of the drug reabsorbed in the renal tubule ; Freab&rsquo ; intermediate model parameter ; representing the frac

刊名：European Journal of Pharmaceutical Sciences

出版年：2016

4.QSARs for estimating intrinsic hepatic clearance of organic chemicals in humans

作者：Alessandra Pirovano^a ; ^{a.pirovano@science.ru.nl" class="auth_mail" title="E-mail the corresponding author} ; Stefan Brandmaier^b ; Mark A.J. Huijbregts^a ; Ad M.J. Ragas^a ; ^c ; Karin Veltman^d ; A. Jan Hendriks^a

关键词：Quantitative structure&ndash ; activity relationship ; Biotransformation ; Clearance (CLINT) ; Hepatocytes ; Microsomes

刊名：Environmental Toxicology and Pharmacology

出版年：2016

5.Estimating the variability in fraction absorbed as a paradigm for informing formulation development in early clinical drug development

作者：Sarit Cohen Rabbie^a ; ^{sarit.rabbie@astrazeneca.com" class="auth_mail" title="E-mail the corresponding author} ; Paul D. Martin^b ; Talia Flanagan^b ; Abdul W. Basit^a ; Joseph F. Standing^c

关键词：F ; Bioavailability ; fa ; fraction absorbed ; fg ; fraction passing the gut wall ; fh ; fraction escaping hepatic metabolism ; GI ; gastrointestinal ; NLME ; nonlinear mixed effect modelling ; IR ; immediate release ; PR ; prolonged release ; ICH ; international conference on harmonisation ; GCP ; good clinical practice ; CLR ; renal clearance ; CLH ; hepatic clearance ; WT ; weight ; FQ ; liver blood flow ; BPR ; blood/plasma ratio ; CLi ; intrinsic clearance ; LV ; liver volume ; ER ; extraction ratio ; FOCE ; first order condit

刊名：European Journal of Pharmaceutical Sciences

出版年：2016

6.JWH-018 ω-OH, a shared hydroxy metabolite of the two synthetic cannabinoids JWH-018 and AM-2201, undergoes oxidation by alcohol dehydrogenase and aldehyde dehydrogenase enzymes in vitro forming the carboxylic acid metabolite

作者：Niels Bjerre Holm ; ^{niels.holm@sund.ku.dk" class="auth_mail" title="E-mail the corresponding author} ; Carolina Noble ; Kristian Linnet

关键词：ADH ; alcohol dehydrogenase ; ALDH ; aldehyde dehydrogenase ; AO ; aldehyde oxidase ; Clint.micr ; microsomal intrinsic clearance ; CYP ; cytochrome P450 ; EIC ; extracted ion chromatogram ; EMCDDA ; European Monitoring Centre for Drugs and Drug Addiction ; ESI ; electrospray ionization ; HLC ; human liver cytosol ; HLM ; human liver microsomal/microsomes ; JWH-018 ; naphthalen-1-yl-(1-pentylindol-3-yl)methanone ; LC&ndash ; MS ; liquid chromatography&ndash ; mass spectrometry ; NAD(P)+/NAD(P)H ; nicotinamide adenine dinucl

刊名：Toxicology Letters

出版年：2016

7.Metformin and cimetidine: Physiologically based pharmacokinetic modelling to investigate transporter mediated drug-drug interactions

关键词：AUC ; area under the plasma concentration-time curve ; B/P ; blood-to-plasma ratio ; CYP ; cytochrome P450 ; CLint ; intrinsic clearance ; Cmax ; maximum plasma concentration ; CLPD ; passive permeability-surface area product ; DDI ; drug&ndash ; drug interaction ; fa ; fraction absorbed ; Jmax ; maximum rate of active transport ; JOCT1 ; rate of OCT1 transport ; JOCT2 ; rate of OCT2 transport ; ka ; absorption rate constant ; Ki ; inhibition constant ; Km ; Michaelis constant ; Kp ; tissue to plasma partition coefficient ; MA

刊名：European Journal of Pharmaceutical Sciences

出版年：2016

8.Preclinical comprehensive physicochemical and pharmacokinetic profiling of novel nitroimidazole derivative IIIM-019 - A potential oral treatment for tuberculosis

作者：Gurleen Kour^a ; ^b ; Anil Kumar^a ; ^b ; Parvinder Pal Singh^c ; Sumit Sharma^c ; Asha Bhagat^a ; Ram A. Vishwakarma^d ; Zabeer Ahmed^a ; ^{zahmed@iiim.ac.in" class="auth_mail" title="E-mail the corresponding author}

关键词：IIIM-019 ; Physicochemical parameters ; Pharmacokinetics ; Hepatotoxicity ; LC-MS/MS (liquid chromatography tandem mass spectrometry)

刊名：Pulmonary Pharmacology & Therapeutics

出版年：2016

9.Use of solubilizers in preclinical formulations: Effect of Cremophor EL on the pharmacokinetic properties on early discovery compounds

作者：Bo Liu ; ^{bliu@gnf.org" class="auth_mail" title="E-mail the corresponding author} ; William Perry Gordon ; Wendy Richmond ; Todd Groessl ; Tove Tuntland

关键词：Cremophor EL ; Surfactant ; Formulation ; Pharmacokinetics

刊名：European Journal of Pharmaceutical Sciences

出版年：2016

10.“Eat me‿imaging and therapy

作者：Vaishali Bagalkot ; Jeffrey A. Deiuliis ; Sanjay Rajagopalan ; Andrei Maiseyeu ; ^{amaiseyeu@medicine.umaryland.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：PtdSer ; phosphatidylserine ; OVA ; ovalbumin ; PSL ; phosphatidylserine liposomes ; ABL ; apoptotic body like liposomes ; PC ; phosphatidylcholine ; OxLDL ; oxidized low density lipoprotein ; PA ; phosphatidicacid ; PE ; phosphoethanolamine ; AA ; adjuvant arthritis ; IL6 ; interleukin 6 ; IL12 ; interleukin 12 ; IL 10 ; interleukin 10 ; IL1β ; interleukin 1β ; PPAR-γ ; peroxisome proliferator activated receptor ; TGFβ ; transforming growth factor β ; TNFα ; Tumor necrosis factor α ; Ccl5 ; Chemokine (C-C motif) ligand 5 ; Ccl2

刊名：Advanced Drug Delivery Reviews

出版年：2016

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