搜索页_+isosteres

设为首页

收藏本站

网站地图 | English | 公务邮箱

远程访问

NSTL服务站

外文资源

Elsevier电子期刊(256)

在“Elsevier电子期刊”中，命中：256条，耗时：小于0.01 秒

在所有数据库中总计命中：256条

1.Efficient synthesis of Xaa-Gly type (Z)-chloroalkene dipeptide isosteres via organocuprate mediated reduction

作者：Takuya Kobayakawa ; Hirokazu Tamamura ; ^{tamamura.mr@tmd.ac.jp" class="auth_mail" title="E-mail the corresponding author}

关键词：Chloroalkene dipeptide isosteres ; Organocuprate ; Reductive dechlorination

刊名：Tetrahedron

出版年：2016

2.Exploration of the P₃ region of PEXEL peptidomimetics leads to a potent inhibitor of the Plasmodium protease, plasmepsin V

作者：Michelle Gazdik ; Kate E. Jarman ; Matthew T. O&rsquo ; Neill ; Anthony N. Hodder ; Kym N. Lowes ; Helene Jousset Sabroux ; Alan F. Cowman ; Justin A. Boddey ; Brad E. Sleebs ; ^{sleebs@wehi.edu.au" class="auth_mail" title="E-mail the corresponding author}

关键词：Plasmepsin V ; Peptidomimetics ; Arginine isosteres ; Malaria ; PEXEL

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

3.Efficient synthesis of a new compound family, 9-aryl-5H-imidazo[2,1-d][1,2,5]triazepin-6(7H)-ones

作者：Tamá ; s Fö ; ldesi ; Andrá ; s Dancsó ; Gyula Simig ; Balá ; zs Volk ; Má ; tyá ; s Milen ; ^{milen.matyas@egis.hu" class="auth_mail" title="E-mail the corresponding author}

关键词：Nitrogen heterocycles ; Selectivity ; Ring closure ; Benzodiazepines ; Isosteres

刊名：Tetrahedron

出版年：2016

4.Synthesis and evaluation of aporphine analogs containing C1 allyl isosteres at the h5-HT_2A receptor

作者：Shashikanth Ponnala^a ; Nirav Kapadia^a ; ^b ; Sudharshan Madapa^a ; Ian L. Alberts^c ; Wayne W. Harding^a ; ^b ; ^{whardi@hunter.cuny.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Aporphine ; 5-HT2A ; Antagonist ; Adrenergic ; Nantenine

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2015

5.Design, synthesis and transformation of some heteroannulated 3-aminopyridines¡ªpurine isosteres with exocyclic nitrogen atom

作者：Viktor O. Iaroshenko^a ; ^b ; ^{viktor.iaroshenko@uni-rostock.de} ; ^{iva108@googlemail.com} ; Marcelo Vilches-Herrera^a ; Ashot Gevorgyan^a ; Satenik Mkrtchyan^a ; Knar Arakelyan^a ; ^c ; Dmytro Ostrovskyi^a ; Muhammad S.A. Abbasi^a ; Linda Supe^a ; Ani Hakobyan^a ; ^c ; Alexander Villinger^a ; Dmitriy M. Volochnyuk^d ; Andrei Tolmachev^b ; ^d

关键词：Heterocyclisation ; Purine isosteres ; Fused pyridines ; Electron-excessive aminoheterocycles ; Nitro-malonaldehyde

刊名：Tetrahedron

出版年：2013

6.Ynamide Click chemistry in development of triazole VEGFR2 TK modulators

作者：Margaré ; ta Vojti膷ková ; ^a ; ^b ; ^{vojtickova.margareta@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Juraj Dobia&scaron ; ^b ; ^{jur.dobias@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Gilles Hanquet^a ; ^{ghanquet@unistra.fr" class="auth_mail" title="E-mail the corresponding author} ; Gabriela Addová ; ^c ; ^{addova@fns.uniba.sk" class="auth_mail" title="E-mail the corresponding author} ; Rengul Cetin-Atalay^d ; ^{rengul@bilkent.edu.tr" class="auth_mail" title="E-mail the corresponding author} ; Deniz Cansen Yildirim^e ; Andrej Bohá ; 膷^b ; ^f ; ^{andrej.bohac@fns.uniba.sk" class="auth_mail" title="E-mail the corresponding author}

关键词：Oxazole/12 ; 3-triazole isosteric replacement ; Ynamide ; CuACC Click chemistry ; VEGFR2 tyrosine kinase inhibition ; Cytotoxic activity in Huh-7 and Mahlavu hepatocellular carcinoma cell lines ; PI3K/Akt pathway

刊名：European Journal of Medicinal Chemistry

出版年：2015

7.Discovery of diazepane amide DORAs and 2-SORAs enabled by exploration of isosteric quinazoline replacements

作者：Anthony J. Roecker^a ; ^{anthony_roecker@merck.com" class="auth_mail" title="E-mail the corresponding author} ; Swati P. Mercer^a ; Jeffrey M. Bergman^a ; Kevin F. Gilbert^a ; Scott D. Kuduk^a ; C. Meacham Harrell^b ; Susan L. Garson^b ; Steven V. Fox^b ; Anthony L. Gotter^b ; Pamela L. Tannenbaum^b ; Thomayant Prueksaritanont^c ; Tamara D. Cabalu^c ; Donghui Cui^c ; Wei Lemaire^d ; Christopher J. Winrow^b ; John J. Renger^b ; Paul J. Coleman^a

关键词：Orexin ; Antagonists ; Sleep ; Isostere ; Quinazoline

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2015

8.A one-pot, three-component, microwave-assisted synthesis of novel 7-amino-substituted 4-aminopyrazolo[1,5-a][1,3,5]triazine-8-carbonitriles

作者：Felicia Phei Lin Lim^a ; Giuseppe Luna^b ; Anton V. Dolzhenko^a ; ^b ; ^{dolzhenkoav@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; ^{anton.dolzhenko@monash.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Triazine ; Pyrazole ; Purine isostere ; Multicomponent reaction ; Microwave irradiation

刊名：Tetrahedron Letters

出版年：2015

9.Fragment based discovery of arginine isosteres through REPLACE: Towards non-ATP competitive CDK inhibitors

作者：Padmavathy N ; ha Premnath ; Shu Liu ; Tracy Perkins ; Jennifer Abbott ; Erin Anderson ; Campbell McInnes

关键词：Cyclin dependent kinase ; Drug discovery ; Inhibitor ; Anti-tumor therapeutic ; REPLACE

刊名：Bioorganic and Medicinal Chemistry

出版年：1 January, 2014

10.Inhibition of human thymidine phosphorylase by conformationally constrained pyrimidine nucleoside phosphonic acids and their 鈥渙pen-structure鈥?isosteres

作者：Ivana Ko&scaron ; iová ; ¹ ; Ond艡ej &Scaron ; imá ; k¹ ; Natalya Panova ; Milo&scaron ; Bud臎&scaron ; í ; nský ; Magdalena Petrová ; Dominik Rejman ; Radek Liboska ; Ond艡ej Páv ; Ivan Rosenberg ; ^{rosenberg@uochb.cas.cz" class="auth_mail}

关键词：Phosphonate ; Conformationally constrained nucleotide analog ; Human thymidine phosphorylase ; PBMC ; Bi-substrate-like inhibitor ; Michael addition

刊名：European Journal of Medicinal Chemistry

出版年：3 March, 2014

按检索点细分(256)

题名(109)

关键词(50)

文摘(190)

按出版年细分(256)

2027年及以后(5)

2016年(3)

2015年(4)

2013年(11)

2012年(12)

2011年(13)

2010年(15)

2009年(7)

2008年(19)

2007年(17)

2006年(10)

2005年(10)

2004年(8)

2003年(10)

2002年(13)

2001年(9)

2000年(17)

2000年及以前(73)

地址：北京市海淀区学院路29号邮编：100083

电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700