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Elsevier电子期刊(25)

在“Elsevier电子期刊”中，命中：25条，耗时：小于0.01 秒

在所有数据库中总计命中：25条

1.Recombinant factor VIII Fc (rFVIIIFc) fusion protein reduces immunogenicity and induces tolerance in hemophilia A mice

作者：Sriram Krishnamoorthy^a ; ^{sriram.krishnamoorthy@biogen.com" class="auth_mail" title="E-mail the corresponding author} ; Tongyao Liu^a ; Douglas Drager^a ; Susannah Patarroyo-White^a ; Ekta Seth Chhabra^a ; Robert Peters^a ; Neil Josephson^b ; David Lillicrap^c ; Richard S. Blumberg^d ; Glenn F. Pierce^a ; Haiyan Jiang^a ; ^{haiyan.jiang.b@gmail.com" class="auth_mail" title="E-mail the corresponding author}

关键词：FVIII ; factor VIII ; rFVIIIFc ; recombinant human factor VIII Fc ; BDD ; B-domain deleted ; FL-rFVIII ; full length recombinant factor VIII ; Treg ; regulatory T-cells ; TNF-α ; tumor necrosis factor-α ; IFN-γ ; Interferon-γ

刊名：Cellular Immunology

出版年：2016

2.Evaluation of the virus clearance capacity and robustness of the manufacturing process for the recombinant factor VIII protein, turoctocog alfa

作者：Tracey W. Ellgaard ; ^{tryw@novonordisk.com" class="auth_mail" title="E-mail the corresponding author} ; Lene Bindslev ^{lnbi@novonordisk.com" class="auth_mail" title="E-mail the corresponding author} ; Sø ; ren Kamstrup ^{skam@novonordisk.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Turoctocog alfa ; Manufacture ; Virus clearance ; rFVIII ; Virus safety ; Virus clearance evaluation

刊名：Protein Expression and Purification

出版年：2017

3.Pharmacokinetics, tissue distribution and excretion of 40 kDa PEG and PEGylated rFVIII (N8-GP) in rats

作者：Inga Bjø ; rnsdottir ; ^{Inbj@novonordisk.com" class="auth_mail" title="E-mail the corresponding author} ; Ola Sternebring ; Wendela A. Kappers ; Helle Selvig ; Hanne T. Kornø ; Jesper B. Kristensen ; Morten A. Bagger

关键词：AUC ; area under the concentration-time curve ; CL ; total plasma clearance ; CLd ; intercompartmental distribution clearance ; C0 ; concentration at time zero ; CMP-NAN ; cytidine-5&prime ; -monophospho-N-acetylneuraminic acid ; CNS ; central nervous system ; EDTA ; ethylenediaminetetraacetic acid ; ELISA ; enzyme-linked immunosorbent assay ; FIXa ; coagulation Factor FIXa ; FVIII ; coagulation Factor VIII ; FX ; coagulation Factor FX ; GSC ; glycyl sialic acid cytidine monophosphate ; HPLC ; high-performance liquid chro

刊名：European Journal of Pharmaceutical Sciences

出版年：2016

4.Evaluation of the toxicology and pharmacokinetics of recombinant factor VIII Fc fusion protein in animals

作者：Jennifer A. Dumont ; ^{jennifer.dumont@biogen.com" class="auth_mail" title="E-mail the corresponding author} ; Kenneth S. Loveday ^{kenneth.loveday@biogen.com" class="auth_mail" title="E-mail the corresponding author} ; David R. Light ^{david.light@biogen.com" class="auth_mail" title="E-mail the corresponding author} ; Glenn F. Pierce ^{glennfpierce@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Haiyan Jiang ^{haiyan.jiang@biogen.com" class="auth_mail" title="E-mail the corresponding author}

关键词：aPTT ; activated partial thromboplastin time ; AUC&infin ; area under the curve from zero to time infinity ; AUClast ; area under the curve up to the last measurable concentration ; BW ; body weight ; CL ; clearance ; Cmax ; maximum plasma concentration ; ECG ; electrocardiogram ; ELISA ; enzyme-linked immunosorbent assay ; F ; female ; FcRn ; neonatal Fc receptor ; FVIII ; factor VIII ; GLP ; Good Laboratory Practice ; HEK ; human embryonic kidney ; HR ; heart rate ; IgG1 ; immunoglobulin G1 ; M ; male ; MRT ; mean residence

刊名：Thrombosis Research

出版年：2015

5.Development, upscaling and validation of the purification process for human-cl rhFVIII (Nuwiq庐), a new generation recombinant factor VIII produced in a human cell-line

作者：Stefan Winge^a ; ^{stefan.winge@octapharma.se" class="auth_mail" title="E-mail the corresponding author} ; Louise Yderland^a ; Christoph Kannicht^b ; Pim Hermans^c ; Simon Adema^c ; Torben Schmidt^d ; Gustav Gilljam^a ; Martin Linhult^a ; Maya Tiemeyer^e ; Larisa Belyanskaya^f ; Olaf Walter^f

关键词：Haemophilia A ; Recombinant factor VIII ; Human-cl rhFVIII ; Nuwiq® ; Purification process ; Pathogen safety

刊名：Protein Expression and Purification

出版年：2015

6.Influence of factor 5 rs6025 and factor 2 rs1799963 mutation on inhibitor development in patients with hemophilia A - an Israeli-German multicenter database study

作者：Gili Kenet^a ; Christoph Bidlingmaier^b ; Nadja Bogdanova^c ; Carmen Escuriola Ettingshausen^d ; Neil Goldenberg^e ; Sven Gutsche^f ; Susan Halimeh^g ; Susanne Holzhauer^h ; Karin Kurnik^b ; Verena Limpergerⁱ ; Ralf Junkerⁱ ; Ulrike Nowak-Gö ; ttl^j ; ^{leagottl@uksh.de" class="auth_mail}

关键词：BU ; Bethesda units ; ED ; exposure days ; F2 ; Factor 2 rs1799963 ; F5 ; Factor 5 rs6025 ; FVIII ; Factor VIII ; F8 ; Factor 8 genotypes ; HA ; hemophilia A ; HRI ; high-titer inhibitor ; HR/CI ; hazard ratio/confidence interval ; ICH ; intracranial hemorrhage ; IFS ; inhibitor-free survival ; IQR ; Interquartile range ; IT ; thrombophilic risk factor ; OR/CI ; Odds ratio/confidence interval ; PUP ; previously untreated patient ; pdFVIII ; plasma-derived factor VIII product ; rFVIII ; recombinant FVIII product

刊名：Thrombosis Research

出版年：April, 2014

7.PSY19 - Haemophilia A: Annual Cost Comparison Between FL-rFVIII and BDD-rFVIII in France: We Should Compare the Cost Per Patient Instead of the Price Per Unit

作者：H. Haarmann ; J. Epstein ; O. Grumel

刊名：Value in Health

出版年：2013

8.Preclinical efficacy and safety of rVIII-SingleChain (CSL627), a novel recombinant single-chain factor VIII

作者：Sabine B. Zollner ; Elmar Raquet ; Jochen M¨¹ller-Cohrs ; Hubert J. Metzner ; Thomas Weimer ; Ingo Pragst ; Gerhard Dickneite ; Stefan Schulte

关键词：ADA ; anti-drug antibody ; aPCC ; activated prothrombin complex concentrate ; aPTT ; activated partial thromboplastin time ; AUC ; area under the curve ; AUC0&ndash ; 24h ; AUC from 0 to 24 ; hours ; AUC0-last ; AUC from 0 to last timepoint ; BDD ; B-domain deleted

刊名：Thrombosis Research

出版年：2013

9.Characterisation of the post-translational modifications of a novel, human cell line-derived recombinant human factor VIII

作者：Christoph Kannicht^a ; ^{christoph.kannicht@octapharma.com} ; Margareta Ramströ ; m^b ; Guido Kohla^a ; Maya Tiemeyer^c ; Elisabeth Casademunt^c ; Olaf Walter^d ; Helena Sandberg^b

关键词：¦Á-Gal ; Gal¦Á1-3Gal¦Â1-GlcNAc-R ; Asn/N ; asparagine ; BHK ; baby hamster kidney ; CHO ; Chinese hamster ovary ; EIC ; extracted ion chromatogram ; FVIII ; factor VIII ; HA ; Haemophilia A ; HEK ; human embryonic kidney ; HexNAcHexNAc ; hexosamine-hexosamine ; HPAEC-PAD

刊名：Thrombosis Research

出版年：2013

10.Comparability studies of new 3rd generation recombinant human factor VIII GreenGene F after improvement of formulation and viral inactivation/removal process

作者：Sang Hoon Paik^a ; ^b ; ^{shpaik@greencross.com} ; Yong Jae Kim^a ; Sang Kyul Han^a ; Ji-youn Kim^a ; Hanna Park^a ; Young In Park^b ; ^c ;

关键词：B-Domain deleted recombinant factor VIII ; GreenGene F ; Homogeneous FVIII ; Comparability ; Viral inactivation ; Protein characteristics

刊名：Biologicals

出版年：2012

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