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Elsevier电子期刊(64)

在“Elsevier电子期刊”中，命中：64条，耗时：0.0299552 秒

在所有数据库中总计命中：158条

1.Identification of a selective inhibitor of transforming growth factor β-activated kinase 1 by biosensor-based screening of focused libraries

作者：Takaaki Miura^a ; ^{miuratka@chugai-pharm.co.jp} ; Atsushi Matsuo^b ; Terushige Muraoka^b ; Mitsuaki Ide^b ; Kenji Morikami^b ; Takayuki Kamikawa^a ; Masamichi Nishihara^b ; Hirotaka Kashiwagi^b

关键词：TAK1 ; Chemogenomic approach ; Selective Type I inhibitor ; Biophysical screening

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

2.Structure-guided development of covalent TAK1 inhibitors

作者：Li Tan^a ; ^b ; ^j ; Deepak Gurbani^c ; ^d ; ^j ; Ellen L. Weisberg^e ; ^f ; John C. Hunter^c ; ^d ; Lianbo Li^c ; ^d ; Douglas S. Jones^g ; ^h ; Scott B. Ficarro^a ; ^b ; Samar Mowafy^a ; ^b ; ⁱ ; Chun-Pong Tam^a ; ^b ; Suman Rao^a ; ^b ; ^g ; Guangyan Du^a ; ^b ; James D. Griffin^e ; ^f ; Peter K. Sorger^g ; Jarrod A. Marto^a ; ^b ; Kenneth D. Westover^c ; ^d ; ^{Kenneth.Westover@UTSouthwestern.edu} ; Nathanael S. Gray^a ; ^b ; ^{Nathanael_Gray@dfci.harvard.edu}

关键词：Structure-based design ; TAK1 kinase inhibitors ; Covalent inhibitors ; 2 ; 4-Disubstituted pyrimidine ; Structure-activity relationship

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

3.The GABA_B positive allosteric modulators CGP7930 and GS39783 stimulate ERK1/2 signalling in cells lacking functional GABA_B receptors

作者：Maria C. Olianas ; ^{molianas@unica.it} ; Simona Dedoni ; Pierluigi Onali

关键词：CGP7930 (PubChem CID ; 5024764) ; GS39783 (PubChem CID ; 6604928) ; (-)-baclofen (PubChem CID ; 44602) ; SKF97541 (PubChem CID ; 5230) ; CGP55845 (PubChem CID ; 5311042) ; CGP54626 (PubChem CID ; 197584) ; phorbol 12-myristate 13 acetate (PubChem CID ; 27924) ; Go 6850 (PubChem CID ; 2396) ; 5Z-7-oxozeaenol (PubChem CID ; 9863776) ; GW5074 (PubChem CID ; 5924208)

刊名：European Journal of Pharmacology

出版年：2017

4.The p21-activated kinase, PAK2, is important in the activation of numerous pancreatic acinar cell signaling cascades and in the onset of early pancreatitis events

作者：Bernardo Nuche-Berenguer ; Irene Ramos-Á ; lvarez ; R.T. Jensen ; ^{robertj@bdg10.niddk.nih.gov" class="auth_mail" title="E-mail the corresponding author}

关键词：CCK ; COOH-terminal octapeptide of cholecystokinin ; TPA ; 12-O-tetradecanoylphorbol-13-acetate ; PAK ; p21-activated kinases ; SFK ; Src family of kinases ; PKC ; protein kinase C ; PYK2 ; proline-rich tyrosine kinase 2 ; FAK ; focal adhesion kinase ; SHC ; Src homology 1 domain containing transforming protein ; PKD ; protein kinase D ; CAS ; Crk-associated substrate ; PI3K ; phosphatidylinositol-3-CAKβ ; cell adhesion kinase β ; PTEN ; phosphatase and tensin homolog ; Cbl ; casitas B-lineage lymphoma proto-oncogene ; RA

刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

出版年：2016

5.The inhibition of transforming growth factor beta-activated kinase 1 contributed to neuroprotection via inflammatory reaction in pilocarpine-induced rats with epilepsy

作者：Q. Tian^a ; Q. Xiao^a ; W. Yu^b ; M. Gu^a ; N. Zhao^b ; Y. Lü ; ^a ; ^{lyu_yang@126.com" class="auth_mail" title="E-mail the corresponding author}

关键词：ANOVA ; analysis of variance ; AP-1 ; activator protein-1 ; BBB ; blood&ndash ; brain barrier ; COX-2 ; cicloossigenasi-2 ; DMSO ; dimethyl sulfoxide ; ELISA ; enzyme-linked immunosorbent assay ; IL-1β ; interleukin-1β ; IL-6 ; interleukin-6 ; MAPK ; mitogen-activated protein kinase ; NF-kB ; nuclear factor-kappa B ; NMDA ; N-methyl-d-aspartate ; P-TAK1 ; phosphorylated TAK1 ; RT-PCR ; real-time polymerase chain reaction ; SE ; status epilepticus ; SRS ; spontaneous recurrent seizures ; TAK1 ; transforming growth factor beta-ac

刊名：Neuroscience

出版年：2016

6.BIX02189 inhibits TGF-β1-induced lung cancer cell metastasis by directly targeting TGF-β type I receptor

作者：Seong Ji Park^a ; Yu Sun Choi^a ; Seungkoo Lee^b ; Young Jae Lee^c ; Suntaek Hong^c ; Sanghwa Han^a ; Byung-Chul Kim^a ; ^{bckim@kangwon.ac.kr" class="auth_mail" title="E-mail the corresponding author}

关键词：BLI ; bioluminescent imaging ; EGF ; epidermal growth factor ; EMT ; epithelial-to-mesenchymal transition ; ERK ; extracellular-signal-regulated kinase ; Fluc ; firefly luciferase ; MAPK ; mitogen-activated protein kinase ; MEK5 ; mitogen-activated protein kinase/extracellular-signal-regulated kinase5 ; MMP ; matrix metalloproteinase ; PBS ; phosphate buffered saline ; siRNA ; small interfering RNA ; TβRI ; transforming growth factor-β1 receptor type I ; TGF-β1 ; transforming growth factor-β1

刊名：Cancer Letters

出版年：2016

7.Cerbera manghas methanol extract exerts anti-inflammatory activity by targeting c-Jun N-terminal kinase in the AP-1 pathway

作者：Young-Su Yi^b ; ¹ ; Jae Youl Cho^a ; ¹ ; Daewon Kim^c ; ^{dr_dwkim@dankook.ac.kr" class="auth_mail" title="E-mail the corresponding author}

关键词：PG ; prostaglandin ; NO ; nitric oxide ; COX ; cyclooxygenase ; TNF-α ; tumor necrosis factor-alpha ; IL-1β ; interleukin-1 beta ; GAPDH ; glyceraldehyde 3-phosphate dehydrogenase ; NO ; nitric oxide ; TLR ; toll-like receptor ; AP-1 ; activator protein-1 ; ERK ; xtracellular signal-regulated kinase ; JNK ; c-Jun N-terminal kinase ; MKK ; mitogen-activated protein kinase kinase ; TAK ; transforming growth factor beta-activated kinase ; IRAK ; interleukin-1 receptor-associated kinase ; MTT ; 3&ndash4 ; 5-dimethylthiazol-2-yl)

刊名：Journal of Ethnopharmacology

出版年：2016

8.Inactivation of transforming growth factor-β-activated kinase 1 promotes taxol efficacy in ovarian cancer cells

作者：Li Bo^a ; ^b ; Huchuan Cui^c ; Zhengxian Fang^b ; Tao Qun^b ; Caoyun Xia^a ; ^{caoyunxia6@126.com}

关键词：TAK1 ; Taxol ; Ovarian cancer ; 5Z-7-oxozeaenol

刊名：Biomedicine & Pharmacotherapy

出版年：2016

9.Mangiferin protect myocardial insults through modulation of MAPK/TGF-β pathways

作者：Kapil Suchal^a ; ¹ ; Salma Malik^a ; ¹ ; Nanda Gamad^a ; Rajiv Kumar Malhotra^a ; Sameer N. Goyal^b ; Shreesh Ojha^c ; Santosh Kumari^d ; Jagriti Bhatia^a ; Dharamvir Singh Arya^a ; ^{dsarya16@gmail.com" class="auth_mail" title="E-mail the corresponding author}

关键词：CAT ; catalase ; DAP ; diastolic arterial pressure ; ERK1/2 ; extracellular regulated kinase 1/2 ; GSH ; reduced glutathione ; IL-6 ; interleukin-6 ; IR ; ischemia-reperfusion ; JNK ; c-Jun NH2 terminal kinase ; MNG ; mangiferin ; LVEDP ; left ventricular end diastolic pressure ; ± ; LVdP/dt ; rate of change of pressure development ; MAP ; mean arterial pressure ; MAPK ; mitogen activated protein kinase ; MDA ; malondialdehyde ; SAP ; systolic arterial pressure ; SOD ; superoxide dismutase ; TGF-β ; transforming growth fa

刊名：European Journal of Pharmacology

出版年：2016

10.The toll-like receptor 4 antagonist transforming growth factor-β-activated kinase(TAK)-242 attenuates taurocholate-induced oxidative stress through regulating mitochondrial function in mice pancreatic acinar cells

作者：Long-Fei Pan ; MD^a ; Lei Yu ; MD^b ; Li-Ming Wang ; MD^a ; Jun-Tao He ; MD^c ; Jiang-Li Sun ; MD^a ; Xiao-Bo Wang ; MD^a ; Zheng-Hai Bai ; MD^a ; Li-Juan Su ; MD^a ; Hong-Hong Pei ; MD^a ; ^{peihonghong_xjtu@126.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Acute pancreatitis ; Oxidative stress ; Mitochondrial dysfunction ; TLR4

刊名：Journal of Surgical Research

出版年：2016

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