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Wiley电子期刊(17)	ProQuest学位论文(8)	GSW全文库(3)	ACS电子期刊(320)
SpringerLink电子期刊(227)	NATURE电子期刊(1)	Elsevier电子期刊(975)

在“Elsevier电子期刊”中，命中：975条，耗时：0.0279855 秒

在所有数据库中总计命中：1,551条

1.Synthesis and evaluation of N-substituted 2-amino-4,5-diarylpyrimidines as selective adenosine A₁ receptor antagonists

作者：Georgios Alachouzos ; Eelke B. Lenselink ; Thea Mulder-Krieger ; Henk de Vries ; Adriaan P. IJzerman ; Julien Louvel ; ^{j.a.louvel@lacdr.leidenuniv.nl}

关键词：Structure-affinity relationships ; Adenosine A1 receptor ; Adenosine A2A receptor ; Selectivity ; Antagonists

刊名：European Journal of Medicinal Chemistry

出版年：2017

2.Synthesis, biological characterisation and structure activity relationships of aromatic bisamidines active against Plasmodium falciparum

作者：B. Sauer^a ; T.S. Skinner-Adams^b ; A. Bouchut^c ; M.J. Chua^b ; C. Pierrot^c ; F. Erdmann^a ; D. Robaa^a ; M. Schmidt^a ; J. Khalife^c ; K.T. Andrews^b ; W. Sippl^a ; ^{wolfgang.sippl@pharmazie.uni-halle.de}

关键词：Plasmodium falciparum ; Bisamidine ; Furamidine ; Cytotoxicity

刊名：European Journal of Medicinal Chemistry

出版年：2017

3.Discovery of new hit-molecules targeting Plasmodium falciparum through a global SAR study of the 4-substituted-2-trichloromethylquinazoline antiplasmodial scaffold

作者：Justine Desroches^a ; ¹ ; Charline Kieffer^a ; ¹ ; Nicolas Primas^a ; Sé ; bastien Hutter^b ; Armand Gellis^a ; Hussein El-Kashef^c ; Pascal Rathelot^a ; Pierre Verhaeghe^d ; ^{pierre.verhaeghe@univ-tlse3.fr} ; Nadine Azas^b ; Patrice Vanelle^a ; ^{patrice.vanelle@univ-amu.fr}

关键词：Quinazoline ; Quinoline ; Quinoxaline ; Thienopyrimidine ; Trichloromethyl goup ; Plasmodium falciparum ; In vitro antiplasmodial activity ; In vitro HepG2 cytotoxicity ; Structure-activity relationships

刊名：European Journal of Medicinal Chemistry

出版年：2017

4.Design, synthesis and structure-activity relationship of 4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones as potent p53-MDM2 inhibitors

作者：Wei-Huang Zhou^a ; ^b ; Xi-Guo Xu^a ; ^b ; Jin Li^b ; Xiao Min^b ; Jian-Zhong Yao^b ; Guo-Qiang Dong^b ; Chun-Lin Zhuang^b ; ^{zclnathan@163.com} ; Zhen-Yuan Miao^b ; ^{miaozhenyuan@hotmail.com} ; Wan-Nian Zhang^a ; ^b ; ^{zhangwnk@hotmail.com}

关键词：p53-MDM2 ; Protein&ndash ; protein interaction ; Inhibitors ; Drug design ; Structure&ndash ; activity relationships ; Antiproliferative

刊名：Chinese Chemical Letters

出版年：2017

5.Progress in the development of β-lactams as N-Acylethanolamine Acid Amidase (NAAA) inhibitors: Synthesis and SAR study of new, potent N-O-substituted derivatives

作者：R. Petracca^a ; S. Ponzano^a ; S.M. Bertozzi^a ; O. Sasso^a ; D. Piomelli^a ; ^b ; T. Bandiera^a ; F. Bertozzi^a ; ^{fabio.bertozzi@iit.it}

关键词：N-Acylethanolamine acid amidase ; Cysteine hydrolase ; N-O-Substituted β-lactams ; Inhibitors ; Structure&ndash ; activity relationships (SAR)

刊名：European Journal of Medicinal Chemistry

出版年：2017

6.A triple exon-skipping luciferase reporter assay identifies a new CLK inhibitor pharmacophore

作者：Yihui Shi ; Jaehyeon Park ; Chandraiah Lagisetti ; Wei Zhou ; Lidia C. Sambucetti ; Thomas R. Webb ; ^{thomas.webb@sri.com}

关键词：CLK ; cdc2-like kinase ; MDM2 ; mouse double minute 2 homolog ; Luc ; luciferase ; TEA ; triethylamine ; DIPEA ; diisopropylethylamine ; EtOAc ; ethyl acetate

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

7.Efficient and versatile CuNi alloy nanocatalysts for the highly selective hydrogenation of furfural

作者：Jun Wu^a ; ^b ; Guang Gao^a ; Jinlei Li^a ; ^b ; Peng Sun^a ; Xiangdong Long^a ; ^b ; Fuwei Li^a ; ^{fuweili@licp.cas.cn}

关键词：CuNi alloy ; Layered double hydroxides ; Selective hydrogenation ; Furfural ; Highly dispersed

刊名：Applied Catalysis B: Environmental

出版年：2017

8.Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors

作者：Jason D. Katz^a ; ^{jason_katz2@merck.com} ; Andrew Haidle^a ; Kaleen K. Childers^a ; Anna A. Zabierek^a ; James P. Jewell^a ; Yongquan Hou^a ; Michael D. Altman^b ; Alexander Szewczak^c ; Dapeng Chen^d ; Andreas Harsch^d ; Mansuo Hayashi^e ; Lee Warren^e ; Michael Hutton^e ; Hugh Nuthall^e ; Hua-Poo Su^f ; Sanjeev Munshi^f ; Matt G. Stanton^a ; Ian W. Davies^a ; Ben Munoz^a ; Alan Northrup^a

关键词：MARK ; Kinase ; Tau ; Alzheimer&rsquo ; s disease ; Pyrrolopyrimidinone

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

9.Synthesis, crystal structure, biological evaluation, and molecular docking studies of quinoline-arylpiperazine derivative as potent α_1A-adrenoceptor antagonist

作者：Wei Xu^a ; Renwang Jiang^a ; ^{rwjiang2008@126.com} ; Mu Yuan^b ; ^{mryuanmu838@sina.com}

关键词：α1-Adrenoceptor ; Quinoline-arylpiperazine ; X-ray crystallography ; Molecular docking ; Pharmacophoric model

刊名：Journal of Molecular Structure

出版年：2017

10.Design and synthesis of benzodiazepine analogs as isoform-selective human lysine deacetylase inhibitors

作者：D. Rajasekhar Reddy ; Flavio Ballante ; Nancy J. Zhou ; Garland R. Marshall ; ^{garlandm@gmail.com}

关键词：Epigenetics ; Histone deacetylase (HDAC) ; Lysine deacetylase (KDAC) ; Benzodiazepine (BZD) ; Structure-based drug design (SBDD)

刊名：European Journal of Medicinal Chemistry

出版年：2017

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