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在“Elsevier电子期刊”中，命中：719条，耗时：0.0109949 秒

1.Structure-activity relationship studies on 1-(2-oxopropyl)indole-5-carboxylic acids acting as inhibitors of cytosolic phospholipase A₂α: Effect of substituents at the indole 3-position on activity, solubility, and metabolic stability

作者：Martina Arnsmann ; Walburga Hanekamp ; Alwine Schulze Elfringhoff ; Matthias Lehr ; ^{lehrm@uni-muenster.de}

关键词：Cytosolic phospholipase A2α ; Inhibitors ; Indole derivatives ; Metabolic stability ; Ketone reduction ; Glucuronidation ; Aqueous solubility

刊名：European Journal of Medicinal Chemistry

出版年：2017

2.Glucuronidation of clopidogrel by human UGT enzymes: Major contributions by UGT2B7 and UGT2B17

作者：Helinä ; Kahma¹ ; Anne M. Filppula¹ ; Mikko Neuvonen¹ ; Aleksi Tornio² ; E. Katriina Tarkiainen² ; Mikko T. Holmberg² ; Matti K. Itkonen² ; Moshe Finel³ ; Pertti J. Neuvonen² ; Mikko Niemi² ; Janne T. Backman²

刊名：Drug Metabolism and Pharmacokinetics

出版年：2017

3.Metabolite profiles of ginsenosides Rk1 and Rg5 in zebrafish using ultraperformance liquid chromatography/quadrupole-time-of-flight MS

作者：Wenwen Shen¹ ; ² ; Yingjie Wei¹ ; Daoquan Tang² ; Xiaobin Jia¹ ; Bin Chen¹ ; ^{jeromechen@126.com}

关键词：ginsenoside Rg5 ; ginsenoside Rk1 ; metabolism ; ultraperformance liquid chromatography/quadrupole&ndash ; time-of-flight MS ; zebrafish

刊名：Journal of Ginseng Research

出版年：2017

4.Alamethicin for using in bioavailability studies? - Re-evaluation of its effect

作者：Maren Vollmer ^{Maren.Vollmer@chemie.uni-hamburg.de} ; Mirko Klingebiel ^{mikl1710@kdwelt.de} ; Sascha Rohn ; ^{rohn@chemie.uni-hamburg.de} ; Ronald Maul ^{maul@chemie.uni-hamburg.de}

关键词：Clint ; intrinsic clearance ; Clint app. ; apparent intrinsic clearance ; DAD ; diod array detector ; DMSO ; dimethyl sulfoxide ; ER ; endoplasmic reticulum ; fu ; unbound fraction of a drug in the microsomal incubation mixture ; HPLC ; high performance liquid chromatography ; Km ; Michaelis-Menten constant ; P ; partition coefficient ; S ; substrate concentration ; UDP ; uridine diphosphate ; UDPGA ; uridine 5&prime ; -diphosphoglucuronic acid trisodium salt ; UGT ; UDP-glucuronosyltransferase ; v ; velocity ; Vmax ; maximal

刊名：Toxicology in Vitro

出版年：2017

5.In vitro characterization of the glucuronidation pathways of D-luciferin mediated by huamn UDP-glucuronosyltransferases

刊名：Drug Metabolism and Pharmacokinetics

出版年：2017

6.Investigation of characteristics of estradiol 3-glucuronidation in rat brain

刊名：Drug Metabolism and Pharmacokinetics

出版年：2017

7.The role of glucuronidation in drug resistance

作者：Zofia Mazerska ; Anna Mróz ; Monika Pawłowska ; Ewa Augustin ; ^{ewa.augustin@pg.gda.pl" class="auth_mail" title="E-mail the corresponding author}

关键词：UGT-dependent resistance ; Glucuronidation ; ABC transporters ; Antitumor drug resistance ; UGT-modulated pharmacokinetics

刊名：Pharmacology and Therapeutics

出版年：2016

8.Transcriptome association analysis identifies miR-375 as a major determinant of variable acetaminophen glucuronidation by human liver

作者：Ioannis Papageorgiou^a ; ^{johnp@vetmed.wsu.edu" class="auth_mail" title="E-mail the corresponding author} ; Marina Freytsis^b ; ^{Marina.Freytsis@tufts.edu" class="auth_mail" title="E-mail the corresponding author} ; Michael H. Court^a ; ^{michael.court@vetmed.wsu.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：ALF ; acute liver failure ; NAPQI ; N-acetyl-p-benzoquinone imine ; UGT ; UDP-glucuronosyltransferase ; SULT ; sulfotransferase ; CYP ; cytochrome P450 ; 3&prime ; -UTR ; 3&prime ; -untranslated region ; SNP ; single nucleotide polymorphism ; miRNA ; microRNA ; UDPGA ; uridine diphosphate glucuronic acid ; qPCR ; quantitative real-time PCR ; AhR ; aryl hydrocarbon receptor ; MRE ; miRNA response element ; HNF1A ; hepatocyte nuclear factor 1-alpha ; HNF1B ; hepatocyte nuclear factor 1-beta ; Nrf2 ; nuclear factor erythroid 2-rel

刊名：Biochemical Pharmacology

出版年：2016

9.Wedelolactone metabolism in rats through regioselective glucuronidation catalyzed by uridine diphosphate-glucuronosyltransferases 1As (UGT1As)

作者：Liang Li^b ; ¹ ; Xue-juan Huang^a ; ¹ ; Jian-long Peng^b ; Ming-yue Zheng^b ; Da-fang Zhong^b ; Chao-feng Zhang^a ; ² ; ^{njchaofeng@126.com" class="auth_mail" title="E-mail the corresponding author} ; Xiao-yan Chen^b ; ^{xychen@simm.ac.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：Wedelolactone ; Metabolism ; Uridine diphosphate-glucuronosyltransferase (UGT) ; Molecular docking

刊名：Phytomedicine

出版年：2016

10.Cremophor EL-based nanoemulsion enhances transcellular permeation of emodin through glucuronidation reduction in UGT1A1-overexpressing MDCKII cells

作者：Tianpeng Zhang^a ; ¹ ; Dong Dong^b ; ¹ ; Danyi Lu^a ; Shuai Wang^a ; Baojian Wu^a ; ^{bj.wu@hotmail.com" class="auth_mail" title="E-mail the corresponding author}

关键词：DMEM ; Dulbecco&rsquo ; s modified Eagle&rsquo ; s medium ; FBS ; fetal bovine serum ; SDS ; sodium dodecyl sulfonate ; MCT ; medium chain triglycerides ; MDCK1A1 cells ; UGT1A1-overexpressing MDCKII cells ; UDPGA ; uridine diphosphoglucuronic acid ; UGT ; UDP-glucuronosyltransferase ; EMO-NE ; emodin nanoemulsion ; TEM ; transmission electron microscopy ; EMO ; emodin ; EMO-G ; emodin glucuronide ; UPLC ; ultra performance liquid chromatography

刊名：International Journal of Pharmaceutics

出版年：2016

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