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在“Elsevier电子期刊”中，命中：143条，耗时：小于0.01 秒

1.A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFR^L858R/T790M mutant with improved pharmacokinetic properties

作者：Lei Yu^a ; ^b ; Minhao Huang^a ; ^b ; Tianfeng Xu^a ; ^b ; Linjiang Tong^d ; Xiao-e Yan^e ; Zhang Zhang^a ; Yong Xu^a ; Caihong Yun^e ; Hua Xie^d ; ^{hxie@simm.ac.cn} ; Ke Ding^a ; ^c ; ^{ding_ke@gibh.ac.cn} ; Xiaoyun Lu^c ; ^{luxy2016@jnu.edu.cn}

关键词：EGFRT790M mutant ; Pyrido[2 ; 3-d]pyrimidin-7-ones ; Pharmacokinetic property ; NSCLC ; Irreversible inhibitor

刊名：European Journal of Medicinal Chemistry

出版年：2017

2.Shikonin inhibits gefitinib-resistant non-small cell lung cancer by inhibiting TrxR and activating the EGFR proteasomal degradation pathway

作者：Xia Li¹ ; Xing-Xing Fan¹ ; Ze-Bo Jiang ; Wings TY Loo ; Xiao-Jun Yao ; Elaine Lai-Han Leung ; ^{lhleung@must.edu.mo} ; Louis WC Chow ; ^{wcchow@must.edu.mo} ; Liang Liu ; ^{lliu@must.edu.mo}

关键词：NSCLC ; non-small cell lung cancer cell ; ROS ; reactive oxygen species ; EGFR ; epidermal growth factor receptor ; T790M ; a substitution mutation of threonine with methionine at position 790 of EGFR ; TrxR ; thioredoxin reductases ; MTT ; 3-(4 ; 5-dimetrylthiazol)-2 ; 5-diphenyltetrazolium bromide ; DCFDA ; dichlorofluorescein diacetate ; PBS ; phosphate-buffered saline ; RIPA ; radioimmunoprecipitation assay ; PARP ; poly (ADP-ribosyl) polymerase ; NAC ; N-acetyl-l-cysteine ; MG132 ; proteasomal degradation pathway inh

刊名：Pharmacological Research

出版年：2017

3.EAI045: The fourth-generation EGFR inhibitor overcoming T790M and C797S resistance

作者：Shuhang Wang^a ; Yongping Song^b ; Delong Liu^b ; ^{delong_liu@nymc.edu}

关键词：EGFR ; EAI045 ; TKI ; AZD9291 ; Rociletinib

刊名：Cancer Letters

出版年：2017

4.Métastases mammaires des cancers bronchopulmonaires avec mutation de l’EGFR

作者：P. Assouline^a ; ^{p.assouline@gh-nord-essonne.fr} ; M.-B. Lé ; ger-Ravet^b ; R. Saffroy^c ; J. Hamelin^c ; A. Bé ; nissad^d ; P. Husleag^a ; A. Lemoine^c ; G. Olivié ; ro^a

关键词：Cancer bronchique ; Site mé ; tastatique atypique ; Mé ; tastase mammaire ; Mutation EGFR ; Mutation T790M

刊名：Revue des Maladies Respiratoires

出版年：2017

5.Osimertinib effective in EGFR T790M-positive lung cancer

作者：Susan Mayor

刊名：The Lancet Oncology

出版年：2017

6.Synthesis and biological evaluation of azole-diphenylpyrimidine derivatives (AzDPPYs) as potent T790M mutant form of epidermal growth factor receptor inhibitors

作者：Zhendong Song^a ; ^&dagger ; ; Yue Jin^a ; ^&dagger ; ; Yang Ge^a ; Changyuan Wang^a ; Jianbin Zhang^a ; Zeyao Tang^a ; Jinyong Peng^a ; Kexin Liu^a ; Yanxia Li^b ; ^{liyanxia001@163.com" class="auth_mail" title="E-mail the corresponding author} ; Xiaodong Ma^a ; ^{xiaodong.ma@139.com" class="auth_mail" title="E-mail the corresponding author}

关键词：NSCLC ; EGFR T790M ; Inhibitors ; Synthesis ; Azole-diphenylpyrimidine

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

7.The marine-derived pachycladin diterpenoids as novel inhibitors of wild-type and mutant EGFR

作者：Mohamed M. Mohyeldin ^{mohyelmm@warhawks.ulm.edu} ; Mohamed R. Akl ^{mohamedreda_pharmacy@yahoo.com} ; Abu Bakar Siddique ; Hossam M. Hassan¹ ; ^{abuh20050@yahoo.com} ; Khalid A. El Sayed ; ^{elsayed@ulm.edu}

关键词：ATCC ; American type culture collection ; CD30 ; cluster of differentiation 30 a type I transmembrane glycoprotein belonging to the TNF receptor superfamily ; CD31 ; platelet endothelial cell adhesion molecule 1 ; EGF ; epidermal growth factor ; EPHB4 ; ephrin type-B receptor 4 ; ERK ; extracellular signal-regulated kinase ; FGFR ; fibroblast growth factor receptor ; FLT3 ; fms-related tyrosine kinase 3 ; JAK2 ; janus kinase 2 ; L858R ; leucine 858 mutated to arginine ; L861Q ; leucine 861 mutated to glutamine ; M ; m

刊名：Biochemical Pharmacology

出版年：2017

8.Coexistence of EGFR T790M mutation and common activating mutations in pretreatment non-small cell lung cancer: A systematic review and meta-analysis

作者：Li-Yang Chen^a ; Miguel A. Molina-Vila^b ; Sheng-Yuan Ruan^a ; Kang-Yi Su^c ; Wei-Yu Liao^a ; Kai-Lun Yu^a ; Chao-Chi Ho^a ; ^{ccho1203@ntu.edu.tw" class="auth_mail" title="E-mail the corresponding author} ; Jin-Yuan Shih^a ; Chong-Jen Yu^a ; James Chih-Hsin Yang^d ; Rafael Rosell^e ; Pan-Chyr Yang^f

关键词：Non-small cell lung cancer ; Epidermal growth factor receptor ; T790M ; L858R ; Exon 19 deletions ; Meta-analysis

刊名：Lung Cancer

出版年：2016

9.Discovery of new [1,4]dioxino[2,3-f]quinazoline-based inhibitors of EGFR including the T790M/L858R mutant

作者：Xuemei Qin^a ; Zhipeng Li^a ; Leifu Yang^b ; Peng Liu^c ; Liming Hu^a ; ^{huliming@bjut.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Chengchu Zeng^a ; Zhiyong Pan^b

关键词：EGFR inhibitors ; Lung cancer ; T790M/L858R mutation ; Quinazoline

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

10.Application of Single-Molecule Amplification and Resequencing Technology for Broad Surveillance of Plasma Mutations in Patients with Advanced Lung Adenocarcinoma

作者：Zheng Wang^&lowast ; ; Gang Cheng^&dagger ; ; Xiaohong Han^&Dagger ; ; Xinlin Mu^§ ; ; Yuhui Zhang^¶ ; ; Di Cui^&lowast ; ; Chang Liu^‖ ; Li Zhang^&lowast ; &lowast ; ; Zaiwen Fan^&dagger ; &dagger ; ; Lingyun Ma^&Dagger ; &Dagger ; ; Li Yang^&lowast ; ; Jing Di^&lowast ; ; David S. Cram^§ ; § ; ; Yuankai Shi^&Dagger ; ; ^{syuankaipumc@126.com} ; Dongge Liu^&lowast ; ; ^{liudongge@sohu.com}

刊名：The Journal of Molecular Diagnostics

出版年：2017

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