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在“Elsevier电子期刊”中，命中：231条，耗时：0.0400149 秒

1.Pharmacological studies on the NOP and opioid receptor agonist PWT2-[Dmt¹]N/OFQ(1-13)

作者：Maria Camilla Cerlesi^a ; Huiping Ding^b ; Mark F. Bird^c ; Norikazu Kiguchi^b ; Federica Ferrari^a ; Davide Malfacini^a ; Anna Rizzi^a ; Chiara Ruzza^a ; David G. Lambert^c ; Mei-Chuan Ko^b ; Girolamo Calo^a ; ; Remo Guerrini^d

关键词：PWT2-[Dmt1]N/OFQ(1&ndash ; 13) ; NOP and opioid receptors ; Receptor binding ; Stimulation of [35S]GTPγS binding ; Calcium mobilization ; Monkey spinal analgesia

刊名：European Journal of Pharmacology

出版年：2017

2.Genetic and pharmacological evidence that endogenous nociceptin/orphanin FQ contributes to dopamine cell loss in Parkinson's disease

作者：Ludovico Arcuri^a ; ^b ; Riccardo Viaro^c ; Simone Bido^a ; ^b ; Francesco Longo^a ; ^b ; Mariangela Calcagno^a ; ^b ; Pierre-Olivier Fernagut^d ; ^e ; Nurulain T. Zaveri^f ; Girolamo Calò ; ^a ; ^b ; Erwan Bezard^d ; ^e ; Michele Morari^a ; ^b ; ^{m.morari@unife.it" class="auth_mail" title="E-mail the corresponding author}

关键词：AAV2/9 ; adeno-associated viral vector pseudotype2/9 ; DA ; dopamine ; hα-syn ; p.A53T human α-synuclein ; MPTP ; 1-methyl-4-phenyl-125 ; 6-tetrahydropyridine ; N/OFQ ; nociceptin/orphanin FQ ; NOP ; N/OFQ peptide receptor ; 6-OHDA ; 6-hydroxydopamine ; p-α-syn ; phosphorylated α-synuclein ; PD ; Parkinson's disease ; ppN/OFQ ; N/OFQ precursor ; SNc ; substantia nigra compacta ; SNr ; substantia nigra reticulata ; TH ; tyrosine hydroxylase

刊名：Neurobiology of Disease

出版年：2016

3.Opioid gene expression changes and post-translational histone modifications at promoter regions in the rat nucleus accumbens after acute and repeated 3,4-methylenedioxy-methamphetamine (MDMA) exposure

作者：Francesca Felicia Caputi ; Martina Palmisano ; Lucia Carboni ; Sanzio Candeletti¹ ; Patrizia Romualdi ; ¹ ; ^{patrizia.romualdi@unibo.it}

关键词：5HT ; serotonin ; BSA ; bovine serum albumin ; ChIP ; chromatin immunoprecipitation ; CPP ; conditioned place preference ; CREB ; cyclic-AMP response-element-binding protein ; DA ; dopamine ; DDCt ; delta&ndash ; delta threshold cycle ; DYN ; dynorphin ; GAPDH ; glyceraldehyde-3-phosphate dehydrogenase ; H ; histone ; K ; lysine ; KOP ; κ-opioid receptor ; MDMA ; 3 ; 4-methylenedioxy-methamphetamine ; N/OFQ ; nociceptin/orphaninFQ ; NOP ; nociceptin receptor ; PBS ; phosphate-buffered saline ; PIC ; protease inhibitor cocktail ; pDY

刊名：Pharmacological Research

出版年：2016

4.NOP receptors in the prelimbic cortex have an inhibitory influence on cardiovascular responses induced by restraint stress

作者：Aline Fassini ; Amé ; rica A. Scopinho ; Leonardo B.M. Resstel ; Fernando M.A. Corrê ; a ; ^{fmdacorr@fmrp.usp.br" class="auth_mail" title="E-mail the corresponding author}

关键词：aCSF ; artificial cerebrospinal fluid ; ANOVA ; analysis of variance ; HR ; heart rate ; IL ; infralimbic cortex ; MAP ; mean arterial pressure ; MPFC ; medial prefrontal cortex ; N/OFQ ; Nociceptin/orphanin FQ ; NOP ; Orphan Opioid Receptor Like-1 (ORL-1) ; PAP ; pulsatile arterial pressure ; PL ; prelimbic cortex ; RS ; restraint stress ; vMPFC ; ventral medial prefrontal cortex

刊名：Neuropeptides

出版年：2016

5.The Importance of Ligand-Receptor Conformational Pairs in Stabilization: Spotlight on the N/OFQ G Protein-Coupled Receptor

作者：Rebecca L. Miller¹ ; ⁶ ; Aaron A. Thompson¹ ; ⁶ ; Claudio Trapella² ; Remo Guerrini² ; Davide Malfacini³ ; Nilkanth Patel⁵ ; Gye Won Han⁴ ; Vadim Cherezov⁴ ; Girolamo Caló ; ³ ; Vsevolod Katritch⁵ ; Raymond C. Stevens¹ ; ⁴ ; ⁵ ; ^{stevens@usc.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Nociceptin/orphanin FQ peptide receptor ; NOP ; ORL-1 ; N/OFQ ; opioid receptor ; G protein-coupled receptor ; GPCR ; membrane protein ; lipidic cubic phase ; BRET ; receptor-ligand conformational pair

刊名：Structure

出版年：2015

6.Discovery of small-molecule nonpeptide antagonists of nociceptin/orphanin FQ receptor: The studies of design, synthesis, and structure-activity relationships for (4-arylpiperidine substituted-methyl)-[bicyclic (hetero)cycloalkanobenzene] derivatives

作者：Shigeo Hayashi ; ^{Shigeo_Hayashi@nifty.com" class="auth_mail" title="E-mail the corresponding author} ; Katsuyo Ohashi ; Sachiko Mihara ; Eriko Nakata ; Chie Emoto ; Atsuko Ohta

关键词：Nociceptin/Orphanin FQ (N/OFQ) ; Human NOP (ORL1) receptor selective antagonist ; Multisite interactions with NOP receptor ; Metabolic stability ; HERG potassium ion channel binding ; Prolong QT interval issues

刊名：European Journal of Medicinal Chemistry

出版年：2016

7.In vitro functional characterization of novel nociceptin/orphanin FQ receptor agonists in recombinant and native preparations

作者：Federica Ferrari^a ; Maria Camilla Cerlesi^a ; Davide Malfacini^a ; Laila Asth^b ; Elaine C. Gavioli^b ; Blair V. Journigan^c ; Uma Gayathri Kamakolanu^c ; Michael E. Meyer^c ; Dennis Yasuda^c ; Willma E. Polgar^d ; Anna Rizzi^a ; Remo Guerrini^e ; Chiara Ruzza^a ; Nurulain T. Zaveri^c ; Girolamo Calo^a ; ^{g.calo@unife.it}

关键词：NOP and classical opioid receptors ; Bioluminescence resonance energy transfer ; Calcium mobilization and mouse colon vas deferens and assays ; Receptor and [35S]GTPγS binding

刊名：European Journal of Pharmacology

出版年：2016

8.Beta-arrestin 2 rather than G protein efficacy determines the anxiolytic-versus antidepressant-like effects of nociceptin/orphanin FQ receptor ligands

作者：L. Asth^a ; C. Ruzza^b ; ^{chiara.ruzza@unife.it" class="auth_mail" title="E-mail the corresponding author} ; D. Malfacini^b ; I. Medeiros^a ; R. Guerrini^c ; N.T. Zaveri^d ; E.C. Gavioli^a ; G. Calo'^b

关键词：N/OFQ ; Anxiety ; Depression ; G protein ; β-arrestin ; NOP receptor partial agonist ; BRET ; Elevated plus maze ; Forced swim test ; Mouse

刊名：Neuropharmacology

出版年：2016

9.Opioid mechanisms and opioid drugs

作者：John McDonald ; David G. Lambert

关键词：G-protein-coupled receptor ; MOP/DOP opioid receptor actions ; NOP-receptor antagonist

刊名：Anaesthesia & Intensive Care Medicine

出版年：2016

10.Effects of thienorphine on the contraction of isolated ureter and bladder of guinea pigs

作者：Peilan Zhou ; Yulei Li ; Zheng Yong ; Hui Yan ; Ruibin Su ; Zehui Gong

关键词：Thienorphine ; Morphine ; Buprenorphine ; Ureter ; Bladder

刊名：European Journal of Pharmacology

出版年：2016

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