作者：Jesse M. Cedarbaum (1)
Diane Stephenson (2)
Richard Rudick (3)
Maria C. Carrillo (4)
Glenn Stebbins (5)
Douglas Kerr (6)
Jill Heemskerk (7)
Wendy R. Galpern (8)
Petra Kaufmann (9)
David Cella (10)
Maria Isaac (11)
Marc K. Walton (12)

1. Neurology Early Clinical Development ; Biogen Idec ; 14 Cambridge Center ; Cambridge ; MA ; 02142 ; USA
2. Coalition Against Major Diseases ; Critical Path Institute ; Tucson ; AZ ; USA
3. Value Based Medicine ; Biogen Idec ; Cambridge ; MA ; USA
4. Medical & Scientific Relations ; Alzheimer鈥檚 Association ; Chicago ; IL ; USA
5. Department of Neurological Sciences ; Rush University Medical Center ; Chicago ; IL ; USA
6. Clinical and Safety Sciences ; Biogen Idec ; Cambridge ; MA ; USA
7. Division of Adult Translational Research ; National Institute of Mental Health ; National Institutes of Health ; Bethesda ; MD ; USA
8. Office of Clinical Research ; National Institute of Neurological Disorders and Stroke ; Bethesda ; MD ; USA
9. Division of Clinical Innovation ; National Center for Advancing Translational Sciences ; National Institutes of Health ; Bethesda ; MD ; USA
10. Northwestern University Feinberg School of Medicine ; Chicago ; IL ; USA
11. European Medicines Agency ; London ; UK
12. Office of Translational Sciences Center for Drug Evaluation and Research Food and Drug Administration ; Silver Spring ; MD ; USA

关键词：Clinical trials ; Clinical outcome assessments

刊名：Neurotherapeutics

出版年：2015

作者：Samuel J. Mann (1)
Michael E. Ernst (2) (3)

1. Division of Nephrology and Hypertension ; NY Presbyterian Hospital-Weill Cornell Medical College ; 424 East 70th St ; New York ; NY ; 10021 ; USA
2. Department of Pharmacy Practice and Science ; College of Pharmacy ; The University of Iowa ; 200 Hawkins Dr ; Iowa City ; IA ; 52242 ; USA
3. Department of Family Medicine ; Carver College of Medicine ; The University of Iowa ; 200 Hawkins Dr ; Iowa City ; IA ; 52242 ; USA

关键词：Diuretics ; Hypertension ; Torsemide ; Hydrochlorothiazide ; Spironolactone ; Chlorthalidone

刊名：Current Hypertension Reports

出版年：2015

作者：George Z. Retsch-Bogart MD (1)
Jill M. Van Dalfsen BS (2)
Bruce C. Marshall MD (3)
Cynthia George MSN ; FNP (3)
Joseph M. Pilewski MD (4)
Eugene C. Nelson DSc ; MPH (5)
Christopher H. Goss MD ; MSc (2) (6)
Bonnie W. Ramsey MD (2) (6)

1. Division of Pulmonology ; Department of Pediatrics ; University of North Carolina at Chapel Hill ; 450 MacNider ; CB#7217 ; 333 South Columbia Street ; Chapel Hill ; NC ; 27599-7217 ; USA
2. Cystic Fibrosis Therapeutics Development Network Coordinating Center ; Seattle Children鈥檚 Research Institute ; Seattle ; WA ; USA
3. Cystic Fibrosis Foundation ; Bethesda ; MD ; USA
4. University of Pittsburgh ; Pittsburgh ; PA ; USA
5. The Dartmouth Institute for Health Policy and Clinical Practice ; Geisel School of Medicine at Dartmouth ; Dartmouth-Hitchcock Health Care System ; Lebanon ; NH ; USA
6. University of Washington ; Seattle ; WA ; USA

关键词：clinical trials ; qualitative research ; quality improvement ; clinical research metrics ; benchmarking ; process improvement ; cystic fibrosis

刊名：Journal of General Internal Medicine

出版年：2014

作者：Holly O Witteman (1) (2) (3)
Selma Chipenda Dansokho (1)
Heather Colquhoun (4)
Angela Coulter (5)
Michèle Dugas (1)
Angela Fagerlin (6) (7)
Anik MC Giguere (1) (2) (8)
Sholom Glouberman (9)
Lynne Haslett (10)
Aubri Hoffman (11)
Noah Ivers (12) (13)
France Légaré (2) (3)
Jean Légaré (14)
Carrie Levin (15)
Karli Lopez (16)
Victor M Montori (17)
Thierry Provencher (1)
Jean-Sébastien Renaud (1) (2)
Kerri Sparling (18)
Dawn Stacey (19) (20)
Gratianne Vaisson (1)
Robert J Volk (21)
William Witteman (3)

1. Office of Education and Continuing Professional Development ; Faculty of Medicine ; Laval University ; Pavillon Ferdinand-Vandry 2881 ; Quebec City ; QC ; G1V 0A6 ; Canada
2. Department of Family and Emergency Medicine ; Laval University ; 1050 avenue de la Médecine ; Pavillon Ferdinand-Vandry 4617 ; Quebec City ; QC ; G1V 0A6 ; Canada
3. Research Centre of the Centre Hospitalier Universitaire de Québec ; 1 rue de l’Espinay ; H?pital Saint Fran?ois d’Assise D6-727 ; Quebec City ; QC ; G1L 3L5 ; Canada
4. Occupational Science and Occupational Therapy ; Rehabilitation Sciences Building ; 160-500 University Ave ; Toronto ; ON ; M5G 1V7 ; Canada
5. Health Services Research Unit ; Nuffield Department of Population Health ; University of Oxford ; Old Road Campus ; Oxford ; OX3 7LF ; UK
6. Center for Bioethics and Social Sciences in Medicine ; Division of General Medicine ; Department of Internal Medicine ; University of Michigan ; 2800 Plymouth Road ; Building 16 ; Rm. 421W ; Ann Arbor ; MI ; 48109-2800 ; USA
7. VA Health Services Research and Development Center of Excellence ; VA Ann Arbor Healthcare System ; Ann Arbor ; MI ; USA
8. Quebec Centre for Excellence in Aging ; Research Centre of the CHU de Quebec ; St-Sacrement Hospital ; Local L2-08 ; 1050 chemin Sainte-Foy ; Quebec City ; QC ; G1S 4L8 ; Canada
9. Patients Canada ; 3560 Bathurst Street ; Toronto ; ON ; M6A 2E1 ; Canada
10. East End Community Health Centre ; 1619 Queen St.E ; Toronto ; ON ; M4L1G4 ; Canada
11. Department of Community and Family Medicine ; The Dartmouth Institute for Health Policy and Clinical Practice ; Geisel School of Medicine at Dartmouth ; 46 Centerra Parkway (HB3250) ; Lebanon ; NH ; USA
12. Family Practice Health Centre and Institute for Health Systems Solutions and Virtual Care ; Women’s College Hospital ; 77 Grenville Street 4th Floor ; Toronto ; ON ; M5S 1B3 ; Canada
13. Department of Family and Community Medicine ; University of Toronto ; 500 University Avenue ; 5th Floor ; Toronto ; ON ; M5G 1V7 ; Canada
14. Arthritis Alliance of Canada ; 403 rue des érables ; Neuville ; Québec ; G0A 2R0 ; Canada
15. Informed Medical Decisions Foundation ; Healthwise ; Inc ; 40 Court Street ; Boston ; MA ; 02108 ; USA
16. 6811 Baxter Terrace Cir ; Anchorage ; AK ; 99504 ; USA
17. Knowledge and Evaluation Research Unit ; Mayo Clinic ; Rochester ; MN ; 55905 ; USA
18. Six Until Me ; 5600 Post Rd ; Unit 228 ; East Greenwich ; RI ; 02818 ; USA
19. School of Nursing ; University of Ottawa ; 451 Smyth Road (RGN 1118) ; Ottawa ; ON ; K1H 8M5 ; Canada
20. Ottawa Hospital Research Institute ; 725 Parkdale Ave ; Ottawa ; ON ; K1Y 4E9 ; Canada
21. Department of Health Services Research ; The University of Texas MD Anderson Cancer Center ; P.O. Box 301402 ; Houston ; TX ; 77230-1444 ; USA

关键词：Patient decision aids ; Decision support ; Shared decision ; making ; Patient education ; Counseling ; User ; centered design ; Human ; centered design ; Patient partnership ; Stakeholder engagement ; Implementation ; Knowledge translation ; Patient ; centered care

刊名：Systematic Reviews

出版年：2015

作者：David Buchbinder (1) (12)
Rebecca Baker (2)
Yu Nee Lee (3)
Juan Ravell (2)
Yu Zhang (4)
Joshua McElwee (5)
Diane Nugent (1)
Emily M. Coonrod (7)
Jacob D. Durtschi (7)
Nancy H. Augustine (7) (8)
Karl V. Voelkerding (7) (8)
Krisztian Csomos (11)
Lindsey Rosen (2)
Sarah Browne (2)
Jolan E. Walter (11) (6)
Luigi D. Notarangelo (6)
Harry R. Hill (10) (7) (8) (9)
Attila Kum谩novics (7) (8)

1. Pediatrics / Hematology ; CHOC Children鈥檚 Hospital鈥擴C Irvine ; Orange ; CA ; USA
12. Division of Hematology ; CHOC Children鈥檚 Hospital ; 1201 La Veta ; Orange ; CA ; 92868 ; USA
2. Laboratory of Clinical Infectious Diseases ; NIAID ; NIH ; Bethesda ; MD ; USA
3. Division of Immunology ; Boston Children鈥檚 Hospital Harvard Medical School ; Boston ; MA ; USA
4. Laboratory of Host Defenses ; National Institutes of Allergy and Infectious Diseases ; NIH ; Bethesda ; MD ; USA
5. Merck Research Laboratories ; Merck & Co. Inc. ; Boston ; MA ; USA
7. ARUP Institute for Clinical and Experimental Pathology ; Salt Lake City ; UT ; USA
8. Department of Pathology ; University of Utah School of Medicine ; Salt Lake City ; UT ; USA
11. Pediatric Allergy & Immunology and the Center for Immunology and Inflammatory Diseases ; Massachusetts General Hospital ; Harvard Medical School ; Boston ; MA ; USA
6. Division of Immunology ; Boston Children鈥檚 Hospital ; Boston ; MA ; USA
10. Department of Pediatrics ; University of Utah School of Medicine ; Salt Lake City ; UT ; USA
9. Department of Internal Medicine ; University of Utah School of Medicine ; Salt Lake City ; UT ; USA

关键词：RAG1 ; RAG deficiency ; primary immunodeficiency ; severe combined immune deficiency ; common variable immunodeficiency disorder ; exome sequencing ; gene panel

刊名：Journal of Clinical Immunology

出版年：2015

作者：Jonas Ecker (1)
Ina Oehme (1)
Ralph Mazitschek (2) (3)
Andrey Korshunov (4) (5)
Marcel Kool (6) (7)
Thomas Hielscher (8)
Judit Kiss (1) (9)
Florian Selt (1) (9)
Carina Konrad (1)
Marco Lodrini (1) (10)
Hedwig E Deubzer (1) (10) (9)
Andreas von Deimling (4) (5)
Andreas E Kulozik (9)
Stefan M Pfister (6) (7) (9)
Olaf Witt (1) (9)
Till Milde (1) (9)

1. Clinical Cooperation Unit Pediatric Oncology (G340) ; German Cancer Research Center (DKFZ) ; Im Neuenheimer Feld 280 ; 69120 ; Heidelberg ; Germany
2. Center for Systems Biology ; Massachusetts General Hospital ; Boston ; MA ; 02114 ; USA
3. The Broad Institute of Harvard and MIT ; Cambridge ; Massachusetts ; 02142 ; USA
4. Department of Neuropathology ; University Hospital Heidelberg ; Im Neuenheimer Feld 224 ; 69120 ; Heidelberg ; Germany
5. Clinical Cooperation Unit Neuropathology (G380) ; German Cancer Research Center (DKFZ) ; and German Cancer Consortium (DKTK) ; Heidelberg ; Germany
6. Division of Pediatric Neurooncology (B062) ; German Cancer Research Center (DKFZ) ; Heidelberg ; Germany ; and German Cancer Consortium (DKTK) ; Heidelberg ; Germany
7. German Cancer Consortium (DKTK) ; Heidelberg ; Germany
8. Division of Biostatistics (C060) ; German Cancer Research Center (DKFZ) ; Heidelberg ; Germany
9. Section of Pediatric Brain Tumors ; Department of Pediatric Oncology ; Hematology and Immunology ; University Hospital Heidelberg ; Im Neuenheimer Feld 430 ; 69120 ; Heidelberg ; Germany
10. Department of Pediatric Hematology ; Oncology and Bone Marrow Transplantation ; Charit茅 - University Medicine Berlin ; CVK ; CC17 ; Augustenburger Platz 1 ; 13353 ; Berlin ; Germany

关键词：Medulloblastoma ; HDAC ; HDAC inhibitor ; HDAC2 ; MYC

刊名：Acta Neuropathologica Communications

出版年：2015

作者：Ronald Boellaard (1)
Roberto Delgado-Bolton (2)
Wim J. G. Oyen (3)
Francesco Giammarile (4)
Klaus Tatsch (5)
Wolfgang Eschner (6)
Fred J. Verzijlbergen (7)
Sally F. Barrington (8)
Lucy C. Pike (8)
Wolfgang A. Weber (9)
Sigrid Stroobants (10)
Dominique Delbeke (11)
Kevin J. Donohoe (12)
Scott Holbrook (13)
Michael M. Graham (14)
Giorgio Testanera (15)
Otto S. Hoekstra (1)
Josee Zijlstra (16)
Eric Visser (3)
Corneline J. Hoekstra (17)
Jan Pruim (18)
Antoon Willemsen (18)
Bertjan Arends (19)
J枚rg Kotzerke (20)
Andreas Bockisch (21)
Thomas Beyer (22)
Arturo Chiti (15)
Bernd J. Krause (23)

1. Department of Radiology & Nuclear Medicine ; VU University Medical Centre ; De Boelelaan 1117 ; 1081 HV ; Amsterdam ; The Netherlands
2. Department of Diagnostic Imaging (Radiology) and Nuclear Medicine ; San Pedro Hospital and Centre for Biomedical Research of La Rioja (CIBIR) ; University of La Rioja ; Logro帽o ; La Rioja ; Spain
3. Department of Radiology & Nuclear Medicine ; Radboud University Nijmegen Medical Centre ; Nijmegen ; The Netherlands
4. Department of Nuclear Medicine ; Centre Hospitalier Universitaire de Lyon ; Lyon ; France
5. Department of Nuclear Medicine ; Municipal Hospital Karlsruhe Inc. ; Karlsruhe ; Germany
6. Department of Nuclear Medicine ; University of Cologne ; Cologne ; Germany
7. Department of Nuclear Medicine ; Erasmus Medical Center ; Rotterdam ; The Netherlands
8. PET Imaging Centre ; St Thomas鈥?Hospital ; Division of Imaging Sciences and Biomedical Engineering ; King鈥檚 College London ; King鈥檚 Health Partners ; London ; UK
9. Department of Radiology ; Memorial Sloan Kettering Center ; New York ; NY ; USA
10. Department of Nuclear Medicine ; Antwerp University Hospital ; Antwerp ; Belgium
11. Department of Radiology and Radiological Sciences ; Vanderbilt University Medical Center ; Nashville ; TN ; USA
12. Beth Israel Deaconess Medical Center ; Boston ; MA ; USA
13. Invivo Molecular Imaging LLC ; Gray ; TN ; USA
14. Department of Radiology ; University of Iowa ; Iowa City ; IA ; USA
15. Department of Nuclear Medicine ; Humanitas Clinical and Research Center ; Rozzano ; MI ; Italy
16. Department of Hematology ; VU University Medical Centre ; Amsterdam ; The Netherlands
17. Department of Nuclear Medicine ; Jeroen Bosch Hospital ; Den Bosch ; The Netherlands
18. Department of Nuclear Medicine & Molecular Imaging ; University Medical Centre Groningen ; Groningen ; The Netherlands
19. Department of Clinical Physics ; Catharina Hospital ; Eindhoven ; The Netherlands
20. Clinic and Outpatient Clinic for Nuclear Medicine ; University Hospital Dresden ; Dresden ; Germany
21. Clinic for Nuclear Medicine ; University Hospital Essen ; Essen ; Germany
22. Centre for Medical Physics and Biomedical Engineering ; Medical University of Vienna ; Vienna ; Austria
23. Department of Nuclear Medicine ; University Hospital Rostock ; Rostock ; Germany

关键词：FDG ; PET/CT ; Imaging procedure ; Tumour ; Oncology ; Quantification

刊名：European Journal of Nuclear Medicine and Molecular Imaging

出版年：2015

作者：R. Ryanne Wu MD (1) (2)
Linda S. Kinsinger MD ; MPH (3)
Dawn Provenzale MD ; MS (1) (4) (5)
Heather A. King Ph.D. (1) (2)
Patricia Akerly CRNP (6)
Lottie K. Barnes MPH ; CHES (4)
Santanu K. Datta Ph.D. (1) (2)
Janet M. Grubber MSPH (1) (2)
Nicholas Katich BS (6)
Rebecca B. McNeil Ph.D. (4) (7)
Robert Monte RPh ; MBA (6)
Nina R. Sperber Ph.D. (1) (2)
David Atkins MD ; MPH (8)
George L. Jackson Ph.D. ; MHA (1) (2)

1. Health Services Research & Development (HSR&D) Center for Health Services Research in Primary Care ; Durham Veterans Affairs Medical Center ; HSR&D Services (152) ; 508 Fulton Street ; Durham ; NC ; 27705 ; USA
2. Division of General Internal Medicine ; Department of Medicine ; School of Medicine ; Duke University ; Durham ; NC ; USA
3. National Center for Health Promotion and Disease Prevention (NCP) ; Veterans Health Administration ; Durham ; NC ; USA
4. VA Cooperative Studies Epidemiology Center ; Durham Veteran Affairs Medical Center ; Durham ; NC ; USA
5. Division of Gastroenterology ; Department of Medicine ; School of Medicine ; Duke University ; Durham ; NC ; USA
6. Veterans Engineering Resource Center (VERC) ; Pittsburgh Veterans Affairs Medical Center ; Pittsburgh ; PA ; USA
7. Division of Neonatology ; Medical University of South Carolina ; Charleston ; SC ; USA
8. Health Services Research & Development Service ; Veterans Health Administration ; Washington ; DC ; USA

关键词：implementation research ; program evaluation ; cancer screening

刊名：Journal of General Internal Medicine

出版年：2014

作者：April C. Braddy (1) (2)
Barbara M. Davit (1) (3)
Ethan M. Stier (1)
Dale P. Conner (4)

1. Division of Bioequivalence III ; Office of Bioequivalence ; Office of Generic Drugs ; Center for Drug Evaluation and Research ; U.S. Food and Drug Administration ; Silver Spring ; Maryland ; USA
2. 10903 New Hampshire Avenue ; Silver Spring ; Maryland ; 20993 ; USA
3. Merck ; Sharp & Dohme ; Whitehouse Station ; New Jersey ; USA
4. Office of Bioequivalence ; Office of Generic Drugs ; Center for Drug Evaluation and Research ; U.S. Food and Drug Administration ; Silver Spring ; Maryland ; USA

关键词：bioequivalence ; bioequivalence studies with clinical endpoints ; biowaivers ; dermatopharmacokinetics ; topical dermatological drug products ; vasoconstrictor assay

刊名：The AAPS Journal

出版年：2015

作者：William M. Grady (2) (3)
Sanford D. Markowitz (1)

2. Clinical Research Division ; Fred Hutchison Cancer Research Center ; 1100 Fairview Avenue N. ; D4-100 ; Seattle ; WA ; 98109 ; USA
3. Department of Medicine ; University of Washington ; Seattle ; WA ; USA
1. Department of Medicine ; Case Western Reserve University ; Cleveland ; OH ; USA

关键词：Colon cancer ; Biomarkers ; Microsatellite instability ; MSI ; Chromosome instability ; Epigenomic instability

刊名：Digestive Diseases and Sciences

出版年：2015